| Literature DB >> 35887403 |
Lulu Yu1, Vladimir Majerciak1, Zhi-Ming Zheng1.
Abstract
In the published review [...].Entities:
Year: 2022 PMID: 35887403 PMCID: PMC9320314 DOI: 10.3390/ijms23147903
Source DB: PubMed Journal: Int J Mol Sci ISSN: 1422-0067 Impact factor: 6.208
Figure 1Papillomavirus genome structure, annotated ORFs, and conserved ACS in the origin of replication (Ori). (a) HPV16 genome and annotated ORFs. The non-structural proteins from the early region of the genome, including E1, E2, E1^E4, E5, E6, E7, and E8^E2, are shown in purple. The viral capsid proteins, L1 and L2, from the late region of the genome are shown in blue. URR (yellow), upstream regulatory region. PE and PL mark the early and late promoters, and pAE and pAL stand for the early and late polyadenylation sites. (b) Conservation of the mammalian ARS consensus sequence (ACS) [16] in the Ori of selected papillomavirus genomes. Shown in this panel are conserved bases with position weight matrix (sequence logo bits) of the 167 predicted ACS elements [16] in comparison with the viral Ori sequences from the selected viral URR tail (red)-head (black) regions. Adapted with permission from Ref. [16]. Copyright 2018 Springer Nature. ARS—autonomously replicating sequence.