| Literature DB >> 3588650 |
A Brambilla, A Ghiorzi, A Giachetti.
Abstract
Single intravenous administration of platelet activating factor (PAF; 4 micrograms/kg) induced reproducible gastric damage in the conscious rat which was prevented by WEB 2086, a potent and specific PAF-antagonist. Intravenous and oral ED50s in protecting rats from gastric damage were 61 and 633 micrograms/kg, respectively. Because of the reported association between septic shock and gastrointestinal ulceration, the therapeutic potential of PAF-antagonists might be broader than previously thought.Entities:
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Year: 1987 PMID： 3588650 DOI： 10.1016/0031-6989(87)90004-x
Source DB: PubMed Journal: Pharmacol Res Commun ISSN： 0031-6989