Literature DB >> 3588310

Oestrogen regulates cathepsin D mRNA levels in oestrogen responsive human breast cancer cells.

B R Westley, F E May.   

Abstract

A cDNA library was constructed from the mRNA of the ZR-75 oestrogen responsive human breast cancer cell line and screened for oestrogen regulated mRNA sequences. Of the recombinants isolated, 30 contained cDNA that corresponded to a single mRNA species of 2.1 kb that was induced between 10 and 15 fold by oestradiol treatment. The sequence of the entire open reading frame and 3' non-coding region of the mRNA was determined and shown to encode the aspartyl protease cathepsin D. The induction of cathepsin D mRNA is specific for oestrogen and is maximal at 3 X 10(-10) M. Cathepsin D mRNA levels were increased by oestrogen in 3 oestrogen responsive breast cancer cell lines. Cathepsin D mRNA was expressed but not regulated in an oestrogen receptor negative breast tumour cell line, BT 20, and in 2 other malignant cell lines, Hela and A431.

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Year:  1987        PMID： 3588310      PMCID： PMC340781          DOI： 10.1093/nar/15.9.3773

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  35 in total

1.  Establishment and characterization of a cell line of human breast carcinoma origin.

Authors:  I Keydar; L Chen; S Karby; F R Weiss; J Delarea; M Radu; S Chaitcik; H J Brenner
Journal:  Eur J Cancer       Date:  1979-05       Impact factor: 9.162

2.  Oestrogen-responsive human breast cancer in long term tissue culture.

Authors:  M E Lippman; G Bolan
Journal:  Nature       Date:  1975-08-14       Impact factor: 49.962

3.  Detection of specific sequences among DNA fragments separated by gel electrophoresis.

Authors:  E M Southern
Journal:  J Mol Biol       Date:  1975-11-05       Impact factor: 5.469

4.  Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I.

Authors:  P W Rigby; M Dieckmann; C Rhodes; P Berg
Journal:  J Mol Biol       Date:  1977-06-15       Impact factor: 5.469

5.  A human cell line from a pleural effusion derived from a breast carcinoma.

Authors:  H D Soule; J Vazguez; A Long; S Albert; M Brennan
Journal:  J Natl Cancer Inst       Date:  1973-11       Impact factor: 13.506

6.  Cathepsins BI and D. Action on human cartilage proteoglycans.

Authors:  R I Morrison; A J Barrett; J T Dingle; D Prior
Journal:  Biochim Biophys Acta       Date:  1973-04-12

7.  Estrogen control of progesterone receptor in human breast cancer: role of estradiol and antiestrogen.

Authors:  K B Horwitz; Y Koseki; W L McGuire
Journal:  Endocrinology       Date:  1978-11       Impact factor: 4.736

Review 8.  Evolution in the structure and function of carboxyl proteases.

Authors:  J Tang
Journal:  Mol Cell Biochem       Date:  1979-07-31       Impact factor: 3.396

9.  Establishment and characterization of three new continuous cell lines derived from human breast carcinomas.

Authors:  L W Engel; N A Young; T S Tralka; M E Lippman; S J O'Brien; M J Joyce
Journal:  Cancer Res       Date:  1978-10       Impact factor: 12.701

10.  Nerve growth factor receptors on human melanoma cells in culture.

Authors:  R N Fabricant; J E De Larco; G J Todaro
Journal:  Proc Natl Acad Sci U S A       Date:  1977-02       Impact factor: 11.205
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  28 in total

1.  Expression and maturation of human cathepsin D in baby-hamster kidney cells.

Authors:  M Horst; A Hasilik
Journal:  Biochem J       Date:  1991-01-15       Impact factor: 3.857

2.  Cathepsin D-related disease-free interval in pT1 primary breast carcinomas: a pilot study.

Authors:  D Nikolić-Vukosavljević; M Markićević; G Grujić-Adanja; A Petrović; K Kanjer; Z Nesković-Konstantinović
Journal:  Clin Exp Metastasis       Date:  2005       Impact factor: 5.150

3.  Decreased expression of integrin adhesive protein receptors in adenocarcinoma of the breast.

Authors:  M M Zutter; G Mazoujian; S A Santoro
Journal:  Am J Pathol       Date:  1990-10       Impact factor: 4.307

Review 4.  B lymphopoiesis: global factors, local control.

Authors:  P W Kincade
Journal:  Proc Natl Acad Sci U S A       Date:  1994-04-12       Impact factor: 11.205

5.  Modulation of human breast cancer cell adhesion by estrogens and antiestrogens.

Authors:  R Millon; F Nicora; D Muller; M Eber; C Klein-Soyer; J Abecassis
Journal:  Clin Exp Metastasis       Date:  1989 Jul-Aug       Impact factor: 5.150

6.  Western blotting and isoform analysis of cathepsin D from normal and malignant human breast cell lines.

Authors:  L D Laury-Kleintop; E C Coronel; M K Lange; T Tachovsky; S Longo; S Tucker; J A Alhadeff
Journal:  Breast Cancer Res Treat       Date:  1995-08       Impact factor: 4.872

7.  HAX-1 overexpression, splicing and cellular localization in tumors.

Authors:  Alicja Trebinska; Alina Rembiszewska; Karolina Ciosek; Konrad Ptaszynski; Sebastian Rowinski; Jolanta Kupryjanczyk; Janusz A Siedlecki; Ewa A Grzybowska
Journal:  BMC Cancer       Date:  2010-03-02       Impact factor: 4.430

8.  Thioredoxin and thioredoxin reductase influence estrogen receptor alpha-mediated gene expression in human breast cancer cells.

Authors:  Abhi K Rao; Yvonne S Ziegler; Ian X McLeod; John R Yates; Ann M Nardulli
Journal:  J Mol Endocrinol       Date:  2009-07-20       Impact factor: 5.098

9.  Molecular mechanism of inhibition of estrogen-induced cathepsin D gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in MCF-7 cells.

Authors:  V Krishnan; W Porter; M Santostefano; X Wang; S Safe
Journal:  Mol Cell Biol       Date:  1995-12       Impact factor: 4.272

10.  Diarylheptanoid phytoestrogens isolated from the medicinal plant Curcuma comosa: biologic actions in vitro and in vivo indicate estrogen receptor-dependent mechanisms.

Authors:  Wipawee Winuthayanon; Pawinee Piyachaturawat; Apichart Suksamrarn; Mathurose Ponglikitmongkol; Yukitomo Arao; Sylvia C Hewitt; Kenneth S Korach
Journal:  Environ Health Perspect       Date:  2009-03-23       Impact factor: 9.031
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