Literature DB >> 3587757

Localization of neuron-specific enolase (NSE) mRNA in human brain.

D E Schmechel, P J Marangos, B M Martin, S Winfield, D S Burkhart, A D Roses, E I Ginns.   

Abstract

In situ hybridization with biotinylated DNA and RNA probes derived from the 3' untranslated region of human neuron-specific or gamma gamma-enolase (NSE) permits histochemical detection of NSE mRNA in autopsy samples of human brain. In both aged controls and Alzheimer's disease (AD) patients, NSE probe hybridized with variable intensity to nerve cells in visual cortex and cerebellum, but not to glial or liver cells. These results provide evidence that NSE mRNA is expressed in neurons in human brain tissue, pattern of NSE mRNA expression in unaffected brain regions in AD is qualitatively normal, and NSE mRNA expression may vary widely among different classes of neurons.

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Year:  1987        PMID： 3587757     DOI： 10.1016/0304-3940(87)90721-x

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  6 in total

Review 1.  Neuronal and glial markers of the central nervous system.

Authors:  C M Regan
Journal:  Experientia       Date:  1988-08-15

2.  Non-isotopic RNA probes. Comparison between different labels and detection systems.

Authors:  A Giaid; Q Hamid; C Adams; D R Springall; G Terenghi; J M Polak
Journal:  Histochemistry       Date:  1989

3.  In situ hybridization with digoxigenin-labeled probes: sensitive and reliable detection method applied to myelinating rat brain.

Authors:  H Breitschopf; G Suchanek; R M Gould; D R Colman; H Lassmann
Journal:  Acta Neuropathol       Date:  1992       Impact factor: 17.088

4.  Neuron-specific enolase and its mRNA are highly expressed in large congenital nevi: a study using immunocytochemistry, biochemical assay, and in situ hybridization.

Authors:  Q A Hamid; A E Bishop; D R Springall; C Adams; J M Polak; A A Quaba; A A al Nafussi; P J Marangos; E Ginns
Journal:  J Mol Neurosci       Date:  1989       Impact factor: 3.444

5.  C-terminal peptide of γ-enolase impairs amyloid-β-induced apoptosis through p75(NTR) signaling.

Authors:  Anja Hafner Pišlar; Janko Kos
Journal:  Neuromolecular Med       Date:  2013-07-11       Impact factor: 3.843

6.  γ-Enolase enhances Trk endosomal trafficking and promotes neurite outgrowth in differentiated SH-SY5Y cells.

Authors:  Anja Pišlar; Janko Kos
Journal:  Cell Commun Signal       Date:  2021-12-11       Impact factor: 5.712
  6 in total

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