| Literature DB >> 35876706 |
Frédérique Chammartin1, Katharina Kusejko2,3, Chloé Pasin2,3, Alexandra Trkola3, Matthias Briel1, Patrizia Amico4, Marcel P Stoekle5, Anna L Eichenberger6, Barbara Hasse2, Dominique L Braun3, Macé M Schuurmans7, Thomas F Müller8, Michael Tamm9, Nicolas J Mueller2, Andri Rauch6, Michael T Koller10, Huldrych F Günthard2,3, Heiner C Bucher1, Benjamin Speich1, Irene A Abela2,3.
Abstract
We identified determinants of SARS-CoV-2 mRNA vaccine antibody response in people with HIV (PWH). Antibody response was higher among PWH less than 60 years, with CD4+ cell count superior to 350 cells/μl and vaccinated with mRNA-1273 by Moderna compared with BNT162b2 by Pfizer-BioNTech. Preinfection with SARS-CoV-2 boosted the antibody response and smokers had an overall lower antibody response. Elderly PWH and those with low CD4+ cell count should be prioritized for booster vaccinations.Entities:
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Year: 2022 PMID： 35876706 DOI： 10.1097/QAD.0000000000003246
Source DB: PubMed Journal: AIDS ISSN： 0269-9370 Impact factor: 4.632