We would like to share ideas on the publication “Outcomes of SARS-CoV-2 Infection in Unvaccinated Compared With Vaccinated Solid Organ Transplant Recipients: A Propensity Matched Cohort Study.”[1] Solid organ transplant (SOT) recipients who develop medically attended coronavirus disease 2019 (COVID-19) after 1- or 2-dose vaccination appear to have illness severity equivalent to unprotected patients who develop infection, according to Hall et al.[1] This is consistent with the necessity that SOT users receive 3 or more vaccination doses, according to Hall et al,[1] emphasizing the importance of alternative measures for this population. Booster immunization is critical, as we all agree. In the context of this research, we should be aware of the possibility of asymptomatic COVID-19, which is a prevalent clinical condition.[2] There is a probability that the SOT recipients in this trial had previously asymptomatic COVID-19, and the effect of the vaccine must be interpreted with this possible confounding effect in mind.
Authors: Victoria G Hall; Ghadeer Al-Alahmadi; Javier T Solera; Tina Marinelli; Heloise Cardinal; G V Ramesh Prasad; Sacha A De Serres; Debra Isaac; Rahul Mainra; Caroline Lamarche; Ruth Sapir-Pichhadze; Susan Gilmour; John Matelski; Atul Humar; Deepali Kumar Journal: Transplantation Date: 2022-05-03 Impact factor: 5.385