Reza Bahramabadi1,2, Hassan Yousefi-Daredor1,3, Sahar Rezaeinejad4, Mohammadtaghi Rezayati1,2, Mohammad Kazemi Arababadi1,3. 1. Immunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences Rafsanjan, Iran. 2. Department of Immunology, Faculty of Medicine, Rafsanjan University of Medical Sciences Rafsanjan, Iran. 3. Department of Laboratory Sciences, Faculty of Paramedical, Rafsanjan University of Medical Sciences Rafsanjan, Iran. 4. Department of Internal Medicine, Faculty of Medicine, Rafsanjan University of Medical Sciences Rafsanjan, Iran.
Abstract
BACKGROUND: Idiopathic chronic obstructive pulmonary disease (ICOPD) is a prevalent human disease. The etiology of the disease is yet to be clarified. The main aim of this project was to explore serum levels of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α) and transforming growth factor-beta (TGF-β) in the ICOPD patients in comparison to healthy controls. METHODS: In this cross-sectional study, serum levels of IL-6, TNF-α and TGF-β were evaluated in the 70 non-smoker ICOPD patients and 70 sex and age matched controls, using ELISA technique by the commercial kits from Karmania Pars Gene Company. Analysis of data was performed by parametric independent and Pearson correlation test. RESULTS: Serum levels of IL-6 and TGF-β, but not TNF-α, were significantly decreased in the ICOPD patients in comparison to controls. Serum levels of IL-6, TNF-α and TGF-β were not altered in the ICOPD male in comparison to female and also in mild when compared to moderate ICOPD patients. CONCLUSIONS: Down-regulation of TGF-β may be the main risk factor for deterioration of inflammation in the ICOPD patients. Decreased IL-6 may be related to the idiopathic type of COPD. AJCEI
BACKGROUND: Idiopathic chronic obstructive pulmonary disease (ICOPD) is a prevalent human disease. The etiology of the disease is yet to be clarified. The main aim of this project was to explore serum levels of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α) and transforming growth factor-beta (TGF-β) in the ICOPD patients in comparison to healthy controls. METHODS: In this cross-sectional study, serum levels of IL-6, TNF-α and TGF-β were evaluated in the 70 non-smoker ICOPD patients and 70 sex and age matched controls, using ELISA technique by the commercial kits from Karmania Pars Gene Company. Analysis of data was performed by parametric independent and Pearson correlation test. RESULTS: Serum levels of IL-6 and TGF-β, but not TNF-α, were significantly decreased in the ICOPD patients in comparison to controls. Serum levels of IL-6, TNF-α and TGF-β were not altered in the ICOPD male in comparison to female and also in mild when compared to moderate ICOPD patients. CONCLUSIONS: Down-regulation of TGF-β may be the main risk factor for deterioration of inflammation in the ICOPD patients. Decreased IL-6 may be related to the idiopathic type of COPD. AJCEI
Authors: Laurie L Carr; Sean Jacobson; David A Lynch; Marilyn G Foreman; Eric L Flenaugh; Craig P Hersh; Frank C Sciurba; David O Wilson; Jessica C Sieren; Patrick Mulhall; Victor Kim; C Matthew Kinsey; Russell P Bowler Journal: Chest Date: 2018-02-13 Impact factor: 9.410
Authors: Antonino Di Stefano; Claudia Sangiorgi; Isabella Gnemmi; Paolo Casolari; Paola Brun; Fabio L M Ricciardolo; Marco Contoli; Alberto Papi; Pio Maniscalco; Paolo Ruggeri; Giuseppe Girbino; Francesco Cappello; Stelios Pavlides; Yike Guo; Kian Fan Chung; Peter J Barnes; Ian M Adcock; Bruno Balbi; Gaetano Caramori Journal: Chest Date: 2017-12-28 Impact factor: 9.410