Effect of pyridoxine on plasma levels of HGH, PRL, and TSH in normal women.

The effect of chronic administration of pyridoxine (vitamin B6) on HGH, basal and TRH stimulated PRL and TSH levels was studied in seven healthy female volunteers. HGH and TSH basal levels remained unaffected. Basal PRL and TRH stimulated PRL and TSH levels were slightly reduced without statistical significance (P greater than 0.05). The results indicate, that stimulation of the hypothalamic dopaminergic pathway by pyridoxine is highly variable and unpredictable. Therefore it seems meaningless to recommend vitamin B6 for the treatment of hyperprolactinaemia.