Literature DB >> 3586862

Direct spectrophotometric determination of the two site binding of aluminum to transferrin.

M Cochran, M Cochran, J H Coates, T Kurucsev.   

Abstract

Difference UV spectrophotometry is used to determine the conditional binding constants for aluminum to human transferrin in the presence of HCO3- of initial concentration 18 mM according to a two site model. The values obtained at 37 degrees C and pH 7.4 are: K1 = 3.0 (+/- 0.8) X 10(15) M-2, K2 = 2.9 (+/- 0.7) X 10(15) M-2 for the reactions: Tr + Al3+ + HCO3- = Tr-Al-HCO3 and Tr-Al-HCO3 + Al3+ + HCO3- = Tr-Al2-(HCO3)2 respectively. Possible consequences arising for the transport of aluminum in human serum are discussed.

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Year:  1987        PMID： 3586862     DOI： 10.1016/0024-3205(87)90507-8

Source DB:  PubMed          Journal:  Life Sci        ISSN： 0024-3205            Impact factor:   5.037


  4 in total

1.  Differentiated neuroblastoma cells are more susceptible to aluminium toxicity than developing cells.

Authors:  M Roll; E Banin; H Meiri
Journal:  Arch Toxicol       Date:  1989       Impact factor: 5.153

2.  Disturbances of morphological parameters in blood of rats orally exposed to aluminum chloride.

Authors:  J Chmielnicka; M Nasiadek; R Pínkowski; M Paradowski
Journal:  Biol Trace Elem Res       Date:  1994-09       Impact factor: 3.738

3.  Aluminium transport in blood serum. Binding of aluminium by human transferrin in the presence of human albumin and citrate.

Authors:  S J Fatemi; F H Kadir; G R Moore
Journal:  Biochem J       Date:  1991-12-01       Impact factor: 3.857

4.  High-aluminum-affinity silica is a nanoparticle that seeds secondary aluminosilicate formation.

Authors:  Ravin Jugdaohsingh; Andy Brown; Martin Dietzel; Jonathan J Powell
Journal:  PLoS One       Date:  2013-12-13       Impact factor: 3.240
  4 in total

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