Literature DB >> 35867524

NDM-35-Producing ST167 Escherichia coli Highly Resistant to β-Lactams Including Cefiderocol.

Laurent Poirel1,2,3, José Manuel Ortiz de la Rosa1,2, Zeynep Sakaoglu1, Ayda Kusaksizoglu1, Mustafa Sadek1,2, Patrice Nordmann1,2,3,4.   

Abstract

A multidrug-resistant (carbapenems, aztreonam + avibactam, and cefiderocol) ST167 Escherichia coli clinical isolate recovered from a patient hospitalized in Switzerland produced NDM-35 showing ca. 10-fold increased hydrolytic activity toward cefiderocol compared to NDM-1. The isolate co-produced a CMY-type β-lactamase, exhibited a four amino-acid insertion in PBP3, and possessed a truncated iron transporter CirA protein. Our study identified an association of unrelated resistance mechanisms leading to resistance to virtually all β-lactams in a high-risk E. coli clone.

Entities:  

Keywords:  NDM; aztreonam-avibactam; cefiderocol; metallo-β-lactamase

Mesh：

Substances：

Year:  2022        PMID： 35867524      PMCID： PMC9380521          DOI： 10.1128/aac.00311-22

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.938


  29 in total

Review 1.  The emerging NDM carbapenemases.

Authors:  Patrice Nordmann; Laurent Poirel; Timothy R Walsh; David M Livermore
Journal:  Trends Microbiol       Date:  2011-11-09       Impact factor: 17.079

2.  ESBLs and resistance to ceftazidime/avibactam and ceftolozane/tazobactam combinations in Escherichia coli and Pseudomonas aeruginosa.

Authors:  José-Manuel Ortiz de la Rosa; Patrice Nordmann; Laurent Poirel
Journal:  J Antimicrob Chemother       Date:  2019-07-01       Impact factor: 5.790

3.  Emergence of NDM-5-producing Escherichia coli sequence type 167 clone in Italy.

Authors:  Maria Giufrè; Giulia Errico; Marisa Accogli; Monica Monaco; Laura Villa; Maria Antonietta Distasi; Tito Del Gaudio; Annalisa Pantosti; Alessandra Carattoli; Marina Cerquetti
Journal:  Int J Antimicrob Agents       Date:  2018-02-28       Impact factor: 5.283

Review 4.  New β-Lactam-β-Lactamase Inhibitor Combinations.

Authors:  Dafna Yahav; Christian G Giske; Alise Grāmatniece; Henrietta Abodakpi; Vincent H Tam; Leonard Leibovici
Journal:  Clin Microbiol Rev       Date:  2020-11-11       Impact factor: 26.132

Review 5.  Carbapenem-Resistant Enterobacteriaceae.

Authors:  Alina Iovleva; Yohei Doi
Journal:  Clin Lab Med       Date:  2017-03-11       Impact factor: 1.935

Review 6.  NDM Metallo-β-Lactamases and Their Bacterial Producers in Health Care Settings.

Authors:  Wenjing Wu; Yu Feng; Guangmin Tang; Fu Qiao; Alan McNally; Zhiyong Zong
Journal:  Clin Microbiol Rev       Date:  2019-01-30       Impact factor: 26.132

7.  In Vitro Antimicrobial Activity of a Siderophore Cephalosporin, S-649266, against Enterobacteriaceae Clinical Isolates, Including Carbapenem-Resistant Strains.

Authors:  Naoki Kohira; Joshua West; Akinobu Ito; Tsukasa Ito-Horiyama; Rio Nakamura; Takafumi Sato; Stephen Rittenhouse; Masakatsu Tsuji; Yoshinori Yamano
Journal:  Antimicrob Agents Chemother       Date:  2015-11-16       Impact factor: 5.191

Review 8.  Carbapenemase-Producing Organisms: A Global Scourge.

Authors:  Robert A Bonomo; Eileen M Burd; John Conly; Brandi M Limbago; Laurent Poirel; Julie A Segre; Lars F Westblade
Journal:  Clin Infect Dis       Date:  2018-04-03       Impact factor: 9.079

9.  Cefiderocol: Discovery, Chemistry, and In Vivo Profiles of a Novel Siderophore Cephalosporin.

Authors:  Takafumi Sato; Kenji Yamawaki
Journal:  Clin Infect Dis       Date:  2019-11-13       Impact factor: 9.079

10.  Epidemiology and Diagnostics of Carbapenem Resistance in Gram-negative Bacteria.

Authors:  Patrice Nordmann; Laurent Poirel
Journal:  Clin Infect Dis       Date:  2019-11-13       Impact factor: 9.079
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