Jordan Standlee1, Roneil Malkani2,3. 1. Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. 2. Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. r-malkani@northwestern.edu. 3. Jesse Brown Veterans Affairs Medical Center, Neurology Service, 820 S Damen Ave, Damen Building, 9th floor, Chicago, IL, 60612, USA. r-malkani@northwestern.edu.
Abstract
PURPOSE OF REVIEW: To comprehensively summarize the sleep pathologies associated with movement disorders, focusing on neurodegenerative diseases. RECENT FINDINGS: Mounting evidence has further implicated both sleep and circadian disruption in the pathophysiology of many movement disorders. In particular, recent data illuminate the mechanisms by which poor sleep quality and circadian dysfunction can exacerbate neurodegeneration. In addition, anti-IgLON5 disease is a recently described autoimmune disease with various symptoms that can feature prominent sleep disruption and parasomnia. Many movement disorders are associated with sleep and circadian rhythm disruption. Motor symptoms can cause sleep fragmentation, resulting in insomnia and excessive daytime sleepiness. Many neurodegenerative movement disorders involve brainstem pathology in regions close to or affecting nuclei that regulate sleep and wake. Further, commonly used movement medications may exacerbate sleep concerns. Providers should screen for and address these sleep symptoms to improve function and quality of life for patients and caregivers.
PURPOSE OF REVIEW: To comprehensively summarize the sleep pathologies associated with movement disorders, focusing on neurodegenerative diseases. RECENT FINDINGS: Mounting evidence has further implicated both sleep and circadian disruption in the pathophysiology of many movement disorders. In particular, recent data illuminate the mechanisms by which poor sleep quality and circadian dysfunction can exacerbate neurodegeneration. In addition, anti-IgLON5 disease is a recently described autoimmune disease with various symptoms that can feature prominent sleep disruption and parasomnia. Many movement disorders are associated with sleep and circadian rhythm disruption. Motor symptoms can cause sleep fragmentation, resulting in insomnia and excessive daytime sleepiness. Many neurodegenerative movement disorders involve brainstem pathology in regions close to or affecting nuclei that regulate sleep and wake. Further, commonly used movement medications may exacerbate sleep concerns. Providers should screen for and address these sleep symptoms to improve function and quality of life for patients and caregivers.
Authors: Juan Carlos Gómez-Esteban; Beatriz Tijero; Johanne Somme; Roberto Ciordia; Koldo Berganzo; Idoia Rouco; Jose Luis Bustos; Maria Antonia Valle; Elena Lezcano; Juan J Zarranz Journal: J Neurol Date: 2010-10-19 Impact factor: 4.849
Authors: Sebastian Paus; Hans Michael Brecht; Jürgen Köster; Gert Seeger; Thomas Klockgether; Ullrich Wüllner Journal: Mov Disord Date: 2003-06 Impact factor: 10.338