Shi Zhuan Tan1, David H Steel2,3, Boris V Stanzel4, Martin Bedersdorfer4, Peter Szurman4, Shohista Saidkasimova5, Katja Christina Schielke6, Neruban Kumaran7, David Alistair H Laidlaw7. 1. St Paul's Eye Unit, Liverpool University Hospitals, Liverpool, UK. shizhuan@gmail.com. 2. Sunderland Eye Infirmary, Sunderland, UK. 3. Biosciences Institute, Newcastle University, Newcastle Upon Tyne, UK. 4. Eye Clinic Sulzbach, Knappschaft Hospital Saar, Sulzbach, Germany. 5. Tennent Institute of Ophthalmology, Great Western Road, Glasgow, UK. 6. Department of Ophthalmology, Aalborg University Hospital, Aalborg, Denmark. 7. Department of Ophthalmology, St Thomas' Hospital, London, UK.
Abstract
OBJECTIVES: To investigate the safety and effectiveness of pre-emptive vitrectomy in eyes with severe non-fibrotic proliferative diabetic retinopathy. METHODS: A multi-centre, retrospective, observational study. Pre-emptive vitrectomy was performed in non-fibrotic diabetic eyes with a visual acuity (VA) of 20/50 or better, where there was extensive persistent neovascularisation despite prior panretinal photocoagulation, and where the fellow eye had established sight loss despite vitrectomy for tractional complications. The primary outcome measure was the VA at last visit. RESULTS: Twenty patients were included. The mean age was 39 ± 14 years. Fifteen patients were Type 1 diabetic. The median baseline VA was 20/30 and remained stable at 20/28 at last visit (median follow-up period: 24 months). Eight eyes (40.0%) developed post-operative vitreous cavity haemorrhage; 4 of which required a vitreous cavity washout procedure. There were no post-operative retinal detachments. The index eye remained the significantly better eye at all time points bar one month post-surgery. Regression of retinopathy grading was observed in all eyes. CONCLUSION: In this pilot study, we found no sight loss with pre-emptive diabetic vitrectomy. Better eye status was maintained in this high-risk group. Further study with larger number of patients and longer-term follow-up is indicated.
OBJECTIVES: To investigate the safety and effectiveness of pre-emptive vitrectomy in eyes with severe non-fibrotic proliferative diabetic retinopathy. METHODS: A multi-centre, retrospective, observational study. Pre-emptive vitrectomy was performed in non-fibrotic diabetic eyes with a visual acuity (VA) of 20/50 or better, where there was extensive persistent neovascularisation despite prior panretinal photocoagulation, and where the fellow eye had established sight loss despite vitrectomy for tractional complications. The primary outcome measure was the VA at last visit. RESULTS: Twenty patients were included. The mean age was 39 ± 14 years. Fifteen patients were Type 1 diabetic. The median baseline VA was 20/30 and remained stable at 20/28 at last visit (median follow-up period: 24 months). Eight eyes (40.0%) developed post-operative vitreous cavity haemorrhage; 4 of which required a vitreous cavity washout procedure. There were no post-operative retinal detachments. The index eye remained the significantly better eye at all time points bar one month post-surgery. Regression of retinopathy grading was observed in all eyes. CONCLUSION: In this pilot study, we found no sight loss with pre-emptive diabetic vitrectomy. Better eye status was maintained in this high-risk group. Further study with larger number of patients and longer-term follow-up is indicated.
Authors: Serge Resnikoff; Donatella Pascolini; Daniel Etya'ale; Ivo Kocur; Ramachandra Pararajasegaram; Gopal P Pokharel; Silvio P Mariotti Journal: Bull World Health Organ Date: 2004-12-14 Impact factor: 9.408
Authors: J Fernando Arevalo; Juan G Sanchez; Andres F Lasave; Lihteh Wu; Mauricio Maia; Sergio Bonafonte; Miguel Brito; Arturo A Alezzandrini; Natalia Restrepo; Maria H Berrocal; Mario Saravia; Michel Eid Farah; Jans Fromow-Guerra; Virgilio Morales-Canton Journal: J Ophthalmol Date: 2011-03-30 Impact factor: 1.909