Literature DB >> 35859862

The Ukrainian Factor in Early-Stage Drug Discovery in the Context of Russian Invasion: The Case of Enamine Ltd.

Ivan S Kondratov1,2, Yurii S Moroz3,4, Oleksandr O Grygorenko1,4, Andrey A Tolmachev1,4.   

Abstract

Ukrainian companies occupy an important niche in the global drug discovery process; however, before the Russian invasion, the role of Ukraine was not obvious. The biggest Ukrainian fine chemical supplier, Enamine Ltd, had to stop operation for more than a month, which significantly affected various early-stage drug discovery projects. The role of Enamine in drug discovery and the company's past and future in the context of the Russian invasion are described in this Viewpoint.
© 2022 American Chemical Society.

Entities:  

Year:  2022        PMID： 35859862      PMCID： PMC9290057          DOI： 10.1021/acsmedchemlett.2c00211

Source DB:  PubMed          Journal:  ACS Med Chem Lett        ISSN： 1948-5875            Impact factor:   4.632


  13 in total

1.  Last of the gem-Difluorocycloalkanes: Synthesis and Characterization of 2,2-Difluorocyclobutyl-Substituted Building Blocks.

Authors:  Anton V Chernykh; Kostiantyn P Melnykov; Nataliya A Tolmacheva; Ivan S Kondratov; Dmytro S Radchenko; Constantin G Daniliuc; Dmitriy M Volochnyuk; Sergey V Ryabukhin; Yuliya O Kuchkovska; Oleksandr O Grygorenko
Journal:  J Org Chem       Date:  2019-04-24       Impact factor: 4.354

2.  A Close-up Look at the Chemical Space of Commercially Available Building Blocks for Medicinal Chemistry.

Authors:  Yuliana Zabolotna; Dmitriy M Volochnyuk; Sergey V Ryabukhin; Dragos Horvath; Konstantin S Gavrilenko; Gilles Marcou; Yurii S Moroz; Oleksandr Oksiuta; Alexandre Varnek
Journal:  J Chem Inf Model       Date:  2021-12-20       Impact factor: 4.956

3.  Synthon-based ligand discovery in virtual libraries of over 11 billion compounds.

Authors:  Arman A Sadybekov; Anastasiia V Sadybekov; Yongfeng Liu; Christos Iliopoulos-Tsoutsouvas; Xi-Ping Huang; Julie Pickett; Blake Houser; Nilkanth Patel; Ngan K Tran; Fei Tong; Nikolai Zvonok; Manish K Jain; Olena Savych; Dmytro S Radchenko; Spyros P Nikas; Nicos A Petasis; Yurii S Moroz; Bryan L Roth; Alexandros Makriyannis; Vsevolod Katritch
Journal:  Nature       Date:  2021-12-15       Impact factor: 69.504

4.  Water-Soluble Non-Classical Benzene Mimetics.

Authors:  Vadym V Levterov; Yaroslav Panasyuk; Valentyna O Pivnytska; Pavel K Mykhailiuk
Journal:  Angew Chem Int Ed Engl       Date:  2020-03-18       Impact factor: 15.336

5.  Hindered dialkyl ether synthesis with electrogenerated carbocations.

Authors:  Jinbao Xiang; Ming Shang; Yu Kawamata; Helena Lundberg; Solomon H Reisberg; Miao Chen; Pavel Mykhailiuk; Gregory Beutner; Michael R Collins; Alyn Davies; Matthew Del Bel; Gary M Gallego; Jillian E Spangler; Jeremy Starr; Shouliang Yang; Donna G Blackmond; Phil S Baran
Journal:  Nature       Date:  2019-09-09       Impact factor: 49.962

6.  One-pot parallel synthesis of 1,3,5-trisubstituted 1,2,4-triazoles.

Authors:  Dmytro S Radchenko; Vasyl S Naumchyk; Igor Dziuba; Andrii A Kyrylchuk; Kateryna E Gubina; Yurii S Moroz; Oleksandr O Grygorenko
Journal:  Mol Divers       Date:  2021-04-02       Impact factor: 3.364

7.  Ultra-large library docking for discovering new chemotypes.

Authors:  Jiankun Lyu; Sheng Wang; Trent E Balius; Isha Singh; Anat Levit; Yurii S Moroz; Matthew J O'Meara; Tao Che; Enkhjargal Algaa; Kateryna Tolmachova; Andrey A Tolmachev; Brian K Shoichet; Bryan L Roth; John J Irwin
Journal:  Nature       Date:  2019-02-06       Impact factor: 49.962

8.  Erratum: Generating Multibillion Chemical Space of Readily Accessible Screening Compounds.

Authors:  Oleksandr O Grygorenko; Dmytro S Radchenko; Igor Dziuba; Alexander Chuprina; Kateryna E Gubina; Yurii S Moroz
Journal:  iScience       Date:  2020-12-04

9.  Automated discovery of noncovalent inhibitors of SARS-CoV-2 main protease by consensus Deep Docking of 40 billion small molecules.

Authors:  Francesco Gentile; Michael Fernandez; Fuqiang Ban; Anh-Tien Ton; Hazem Mslati; Carl F Perez; Eric Leblanc; Jean Charle Yaacoub; James Gleave; Abraham Stern; Bill Wong; François Jean; Natalie Strynadka; Artem Cherkasov
Journal:  Chem Sci       Date:  2021-11-17       Impact factor: 9.825

10.  An open-source drug discovery platform enables ultra-large virtual screens.

Authors:  Andras Boeszoermenyi; Zi-Fu Wang; Christoph Gorgulla; Patrick D Fischer; Paul W Coote; Krishna M Padmanabha Das; Yehor S Malets; Dmytro S Radchenko; Yurii S Moroz; David A Scott; Konstantin Fackeldey; Moritz Hoffmann; Iryna Iavniuk; Gerhard Wagner; Haribabu Arthanari
Journal:  Nature       Date:  2020-03-09       Impact factor: 49.962
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