Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Inherited haemoglobin variants in a South African population.

Literature DB >> 3585936

Inherited haemoglobin variants in a South African population.

A R Bird, P Ellis, K Wood, C Mathew, C Karabus.

Abstract

We present the findings of a survey to determine the prevalence of inherited haemoglobin disorders in the Coloured (mixed ethnic origin) population of South Africa. A variety of haemoglobins was found. Of the structural variants, Hb E and Hb S were the most common, the former probably originating from South-East Asia and the latter from East Africa and possibly Madagascar. The alpha+ (-alpha) thalassaemia haplotype is particularly common with an observed frequency of 0.023. Beta thalassaemia was rather less common, while hereditary persistence of fetal haemoglobin was found for the first time in this population group, occurring in two subjects.

Entities: Disease Gene

Mesh：

Substances：

Year: 1987 PMID： 3585936 PMCID： PMC1049998 DOI： 10.1136/jmg.24.4.215

Source DB: PubMed Journal: J Med Genet ISSN： 0022-2593 Impact factor: 6.318

32 in total

1. The preparation of 59Fe-labelled transferrin of high radioactivity for ferrokinetic studies on small laboratory animals.

Authors: J Holá; J Vácha; J Bohácek
Journal: Acta Haematol Date: 1979 Impact factor: 2.195

Inherited haemoglobin variants in a South African population.

1. The preparation of 59Fe-labelled transferrin of high radioactivity for ferrokinetic studies on small laboratory animals.

2. Sickle-cell trait: a family study and a report of three further cases of sickle-cell disease.

3. A new technique for differentiation of hemoglobin.

4. Homozygous haemoglobin-C disease in a white family with special reference to blood autolysis studies.

5. Reliable routine estimation of small amounts of foetal haemoglobin by alkali denaturation.

6. Sickle-cell thalassaemia in Johannesburg: a case discussion and family study.

7. Incidence of Hb Barts and alpha-thalassaemia genotypes in a South African population.

8. Haemoglobin Leiden in a South African negro. A case report.

9. Abnormal haemoglobins in Cape Town; (occurrence and significance).

10. Non-immunological hydrops fetalis: report of 6 cases and a review.

1. Implementation of POCT in the diabetic clinic in a large hospital.

2. Hemoglobin variants identified in the Uganda Sickle Surveillance Study.