Immediate sequential bilateral cataract surgery: patient perceptions and preferences.

BACKGROUND: Recent national data suggests that less than 0.5% of NHS cataract patients undergo immediate sequential bilateral cataract surgery (ISBCS). Since ISBCS improves service efficiency, increasing its practice may help tackle the ever-growing burden of cataract in the UK, and reduce the COVID-19 cataract backlog. Surgeon attitudes are known to be a significant barrier to increasing the practice of ISBCS. However, little is known about patient perceptions of ISBCS.
METHODS: Patients at cataract clinics across three NHS hospital sites were recruited to complete an investigator-led structured questionnaire. Open-ended and closed-ended questions were used to assess awareness of ISBCS, willingness to undergo ISBCS and attitudes towards ISBCS.
RESULTS: Questionnaires were completed by 183 patients. Mean participant age was 70.5 (9.9) years and 58% were female. Forty-three percent were aware of ISBCS, chiefly via clinic staff. Just over a third would choose ISBCS if given the choice, and participants that perceived they were recommended ISBCS were more likely to opt for it. The most common motivator and barrier to uptake of ISBCS was convenience and the perceived risk of complications in both eyes respectively. Concerns related to the recovery period were common, including misunderstandings, such as the need to wear eye patches that obscure both eyes.
CONCLUSIONS: Our study indicates that significantly more NHS patients would be willing to undergo ISBCS if given the choice. The reluctance of surgeons to recommend ISBCS and patient misunderstandings regarding the recovery period may be limiting its uptake.

Introduction

Cataract surgery is already the most frequently performed operation in the NHS, and a 50% increase in cataract prevalence is forecast by 2035 due to the UK’s aging population [1]. This long term growth in demand, compounded by the COVID-19 related backlog of unoperated cataract, has provided impetus to consider what cataract service redesign options exist [1, 2].

Recent Royal College of Ophthalmologists National Ophthalmology Database (NOD) data indicates that less than 0.5% of NHS patients undergoing cataract surgery in both eyes undergo immediate sequential bilateral cataract surgery (ISBCS) in which cataract surgery is performed in both eyes on the same day [3]. Since ISBCS is known to be cost-effective and improve operating room efficiency, it has been proposed that increasing its practice may help pave the way for more sustainable cataract services [3-6].

Surveys conducted prior to the pandemic indicate that hesitancy to offer ISBCS amongst UK based surgeons may be limiting its practice in the NHS, largely due to concerns regarding the risk of bilateral complications such as endophthalmitis [7]. Despite this, a large case series of ISBCS (95,606 patients) reported no incidences of bilateral endophthalmitis, and randomised controlled trials of ISBCS have identified no safety concerns [8-11].

The COVID-19 pandemic has sparked a greater interest in patient perceptions of ISBCS [12-14]. A survey of 267 patients suggested that during the pandemic, 45% of patients on NHS cataract surgery waiting lists would undergo ISBCS if given the choice [13]. While past surveys have provided some valuable insights into patient attitudes towards ISBCS, the use of closed-ended questions has limited participant responses to investigator-provided suggestions, which may overlook more nuanced motivators and barriers to uptake of ISBCS [12-15]. In addition, since most surveys regarding patient perceptions were conducted during the pandemic, the future relevance of such studies is unclear [12-14].

The aim of this study is to quantify the awareness and acceptability of ISBCS and to gain a more complete understanding of patient attitudes by using a questionnaire including open-ended questions. This information will be useful for facilitating service redesign that reflects patient understanding and preferences in relation to ISBCS.

Methods

A cross-sectional study was performed using an investigator-led structured questionnaire containing open-ended and closed-ended questions. The questionnaire was developed in consultation with ophthalmologists internal and external to the host institution and members of the institution’s Public and Patient Involvement and Service Improvement teams. It was then pre-tested and iteratively refined to optimise comprehension.

Patients were recruited between the 14th of June to the 26th of July 2021 from twenty morning and thirteen afternoon cataract clinics across three hospitals sites of Moorfields Eye Hospital NHS Foundation Trust. Patient recruitment took place until responses to open-ended questions reached saturation and new themes or ideas were no longer being offered.

Ophthalmologists were verbally informed of the study design and asked to invite the following patients to complete the questionnaire at the end of their clinic appointment: (1) cataract surgery-naive patients (patients that have never undergone cataract surgery) with visually significant bilateral cataract listed for first eye cataract surgery or ISBCS, (2) post-operative patients listed for second eye cataract surgery following first eye cataract surgery and (3) post-operative patients that had undergone ISBCS or delayed sequential bilateral cataract surgery (DSBCS). Patients that required translation services or were under 18 years old were excluded.

Informed written consent was obtained from all participants prior to completing the questionnaire. Questions were read aloud, and responses were tabulated in summary and recorded in a computer spreadsheet. When there was a lack of clarity, the recorded response was read back to the participant to ensure its accuracy.

The study received ethical approval from the London School of Hygiene and Tropical Medicine Research Ethics Committee and was authorised by the host institution’s audit department. All data collection was performed in accordance with the Declaration of Helsinki.

Participant sex, age and cataract surgical status were obtained directly from hospital records, and employment status was assessed using a closed-ended question. The proportion of participants aware of ISBCS and how these participants became aware was determined using a binary question and an opened-ended question respectively.

To assess patient willingness to undergo ISBCS and attitudes towards ISBCS, participants were asked whether they were given the choice of undergoing ISBCS using a binary question, and whether they had any concern about undergoing ISBCS using an open-ended question. Cataract surgery-naive participants that reported to have been given the choice were asked why they chose to be listed for ISBCS or DSBCS using an open-ended question, and whether the surgeon recommended ISBCS, DSBCS or both options equally using a closed-ended question. The remaining participants were asked whether they would undergo ISBCS if given the choice using a five-point Likert scale, and the reason for this using an open-ended question [16].

Post-operative ISBCS participants were asked whether ISBCS was as expected using a five-point Likert scale and open-ended questions regarding what additional information they would have liked to receive before undergoing ISBCS [16].

For the complete questionnaire used, see the Supplementary Information.

Responses to closed-ended questions are summarised as a proportion of the respondents. Chi-squared tests and unpaired t-tests were conducted to assess for statistical differences in sex, mean age, and employment status between participants that would and would not choose ISBCS using STATA 16.1 (StataCorp. 2019, College Station, TX, USA).

To analyse the responses to the open-ended questions regarding reasons given for choosing and not choosing ISBCS, a list of key phrases was inductively compiled to capture all reasons mentioned. The proportion of responses that contained each reason was calculated for all participants and surgery-naive and post-operative participant subgroups. Due to the similarities in the responses given, reasons for not choosing ISBCS and concerns regarding ISBCS were analysed together. The same method was used for analysing the responses regarding awareness of ISBCS. To summarise responses to the additional questions for post-operative ISBCS participants, representative quotes are reported for each response.

Results

Patient characteristics

Questionnaires were completed by 183 patients. This included 15 (8.2%) cataract surgery-naive participants listed for ISBCS, 51 (27.9%) cataract surgery-naive participants listed for first eye cataract surgery, 73 (39.9%) post-operative participants listed for second eye cataract surgery, 40 (21.9%) post-operative patients that had undergone DBSCS and 4 (2.2%) post-operative patients that had undergone ISBCS.

The mean age (standard deviation) of participants was 70.5 (9.9) years. Seventy-seven (42.1%) participants were male and 106 (57.9%) were female. Ten (5.5%) participants reported to be unemployed, 49 (26.8%) reported to be in full-time or part-time employment and 124 (67.8%) reported to be retired.

Awareness of ISBCS

Of the 183 participants, 78 (42.6%) reported being aware of ISBCS. Forty-six (59.0%) of these were aware of ISBCS via clinic staff and 20 (25.6%) were aware via a family member, friend, or acquaintance. Less common sources of awareness included online and hospital patient information, which was reported by 7 (9.0%) and 6 (7.7%) participants respectively. One (1.3%) participant was unsure how they became aware of ISBCS.

Acceptability of ISBCS

Amongst cataract surgery-naive participants, 27/66 (40.9%) reported being offered ISBCS, 15 (55.6%) of which chose to be listed for ISBCS. Of the surgery-naïve participants listed for ISBCS, 6/15 (40%) perceived that the surgeon recommended ISBCS. Of the 12 surgery-naïve participants that declined the offer to be listed for ISBCS, 1 (8.3%) perceived that the surgeon recommended ISBCS, and 1 (8.3%) perceived that the surgeon recommended DSBSC. The remaining 19/27 (70.4%) surgery-naïve participants offered ISBCS perceived that ISBCS and DSBCS were recommended equally.

Of the 9/117 (7.7%) post-operative patients that reported being offered ISBCS in clinic, 4/9 (44.4%) underwent ISBCS.

Amongst surgery-naive participants not offered ISBCS and post-operative participants, 15/39 (38.5%) and 36/117 (30.8%) agreed respectively that, if given the choice, they would choose ISBCS (Fig. 1). Of the four post-operative ISBCS participants included, three strongly agreed and one disagreed that they would choose ISBCS if given the choice again. The post-operative ISBCS participant that disagreed that they would choose ISBCS if given the choice again also disagreed that ISBCS was as expected. Among the remaining post-operative ISBCS participants, one agreed, one disagreed and one strongly disagreed that ISBCS was as expected. Representative quotes expressing the reasons that participants did not find ISBCS as expected, and additional information participants would have liked to receive before undergoing ISBCS are shown in Fig. 1.

Fig. 1

Patient willingness to undergo ISBCS.

Willingness of participants to undergo ISBCS, and quotations from post-operative ISBCS participants.

By combining the 15 surgery-naive participants that chose to be listed for ISBCS and the 51 participants that agreed they would choose ISBCS if given the choice, it can be estimated that 66/183 (36.1%) participants in our study would choose ISBCS. Likewise, by combining the 12 surgery-naive participants that chose not to be listed for ISBCS and the remaining 89 participants that disagreed they would choose ISBCS if given the choice, it can be estimated that 101/183 (55.2%) participants in our study would not choose ISBCS. The remaining 16/183 (8.7%) participants were neutral towards ISBCS (Fig. 2).

Fig. 2

Patient acceptability of ISBCS.

Diagram summarizing the acceptability of ISBCS to the participants in our study.

As shown in Table 1, there was no statistically significant difference (p > 0.3) in sex, age, and employment status between participants that would and would not choose ISBCS.

Table 1

Characteristics of participants that would and would not choose to undergo ISBCS.

Patient characteristics	Patients that would choose ISBCS	Patients that would not choose ISBCS	P valuea
Sex, n (%)			0.32
Male	32 (48.5%)	41 (40.6%)
Female	34 (51.5%)	60 (59.4%)
Age (years)b
Mean (standard deviation)	71.2 (10.4)	70.6 (9.6)	0.70
Employment status, n (%)			0.62
Full-time/part-time employment	14 (21.2%)	49 (26.8%)
Retired	49 (74.2%)	124 (67.8%)
Unemployed	3 (4.5%)	10 (5.5%)
Total patients	66	101

aChi-squared tests used for sex and employment status and unpaired t-test used for age.

bAge data missing for two participants.

Attitudes towards ISBCS

Seventy-nine participants gave reasons for choosing ISBCS and 142 participants gave reasons for not choosing ISBCS or had concerns regarding ISBCS.

Of the participants that gave responses in favour of ISBCS, the most common reason was convenience or time and travel savings, which was reported by 34/79 (43.0%) participants. The second most common reasons (both reported by 22/79 (27.8%) participants) were to avoid the stress of additional operations or appointments and reduction of waiting time for surgery. The next most common reason (reported by 21/79 (26.6%) participants) was to avoid visual imbalance between the first and second surgery. This included participants that reported concerns regarding having to wait until the second surgery for a new spectacle prescription and issues with reading, balance, and vision between operations. Other less common reasons for choosing ISBCS are shown in Table 2.

Table 2

Reasons given by participants in favour of choosing ISBCS.

Reasons given for choosing ISBCS, n (%)a	Surgery-naive	Post-operative	Overall
Convenience/to save time and travel (as there would be fewer hospital visits)	18 (54.5%)	16 (34.8%)	34 (43.0%)
To avoid the anxiety/stress of an additional operation/additional hospital appointments	11 (33.3%)	11 (23.9%)	22 (27.8%)
To reduce waiting time for surgery	7 (21.2%)	15 (32.6%)	22 (27.8%)
To avoid visual imbalance between the 1st and 2nd surgeryb	4 (12.1%)	17 (37.0%)	21 (26.6%)
To improve eyesight more quickly	10 (30.3%)	8 (17.4%)	18 (22.8%)
To minimize the time requiring eye drops	2 (6.1%)	7 (15.2%)	9 (11.4%)
To reduce time off work	2 (6.1%)	5 (10.9%)	7 (8.9%)
More efficient/beneficial for the NHS	3 (9.1%)	4 (8.7%)	7 (8.9%)
To minimize the time not being able to care for others (e.g., family or dependents)	2 (6.1%)	1 (2.2%)	3 (3.8%)
To avoid the expense of additional spectacles/a blank lens between the 1st and 2nd surgery	0 (0.0%)	2 (4.3%)	2 (2.5%)
The discomfort of surgery is over in one sitting	0 (0.0%)	2 (4.3%)	2 (2.5%)
Total participants	33	46	79

aPercentages add up to more than 100 as many participants mentioned more than one reason in their response.

bThe need for new spectacles after the 1st surgery but having to wait until after the 2nd surgery was mentioned in 8/79 (10.1%) responses; issues with reading, vision and balance between the 1st and 2nd surgery were each mentioned in 5/79 (6.3%) responses.

The most common reason for not choosing ISBCS was the risk of complications in both eyes or concerns about safety, which was reported by 77/142 (54.2%) participants. The second most common concern reported in 48/142 (33.8%) responses was the difficulty of coping with impaired vision in both eyes immediately following the operation.

The only other concerns mentioned in over 10% of responses were regarding the need to wear patches that obscure both eyes after surgery and the need for additional care and support while recovering. All expressed concerns are presented in Table 3.

Table 3

Reasons given by participants against choosing ISBCS.

Reasons given for not choosing ISBCS/concerns regarding ISBCS, n (%)a	Surgery-naive	Post-operative	Overall
The risk of complications (e.g., infection) in both eyes/concerns about safety	27 (57.4%)	50 (52.6%)	77 (54.2%)
The difficulty of coping with impaired vision in both eyes while eyes recover	12 (25.5%)	36 (37.9%)	48 (33.8%)
The need for additional care/support while recovering	8 (17.0%)	11 (11.6%)	19 (13.4%)
The need to wear patches that obscure both eyes after surgery	3 (6.4%)	16 (16.8%)	19 (13.4%)
The difficulty of administering eye drops during the recovery period	2 (4.3%)	9 (9.5%)	11 (7.7%)
Not having sufficient eyesight to travel home after surgery	2 (4.3%)	8 (8.4%)	10 (7.0%)
It would be more painful/uncomfortable	1 (2.1%)	4 (4.2%)	5 (3.5%)
Being less able to care for others (e.g., family or dependents) while recovering	1 (2.1%)	4 (4.2%)	5 (3.5%)
The operation would be longer/the difficulty of lying flat for a long time	0 (0.0%)	4 (4.2%)	4 (2.8%)
Being less able to work while recovering	0 (0.0%)	3 (3.2%)	3 (2.1%)
The difficulty of wearing eye shields on both eyes after surgery	0 (0.0%)	2 (2.1%)	2 (1.4%)
Total participants	47	95	142

aPercentages add up to more than 100 as many participants mentioned more than one reason in their response.

Discussion

Although NICE guidance [NG77] recommends offering ISBCS to most adult cataract patients, it is not widely performed in the NHS, and thus remains largely unheard-of by cataract patients in the UK [3, 13, 17]. In our study, most patients were recruited in clinics that often offer ISBCS. However, only around 40% of participants reported awareness of ISBCS, most of whom became aware via clinic staff. This suggests that unless patients are actively informed about ISBCS, they are unlikely to be aware of it.

A survey conducted prior to and during the early phase of the COVID-19 pandemic indicated that 45% of patients on NHS cataract surgery waiting lists would undergo ISBCS if offered it [13]. In our cross-sectional study conducted during the post-COVID-19 cataract service rebuild, just over a third (36%) of participants reported that they would undergo ISBCS if given the choice. This implies a slight decline in the acceptability of ISBCS as the pandemic has progressed, possibly due to greater concerns about contracting COVID-19 and longer waiting times for surgery during the earlier phase of the pandemic. Nevertheless, since prior to the pandemic less than 0.5% of NHS cataract surgery recorded on the NOD was ISBCS, our findings suggests that from the patient perspective, a post-pandemic increase in practice of ISBCS would be feasible and welcomed [18].

While our study was undertaken across only three NHS cataract provider sites, the demographics of our study population appeared representative of the UK cataract patient population compared to recent NOD data [18].

Since ISBCS improves operating room efficiency and requires fewer hospital visits, it has been suggested that adopting ISBCS as routine practice may help tackle the growing burden of cataract in the UK [3, 4]. This should make it an attractive option to clinicians looking to facilitate patient-centred service redesign. In our study, patient willingness to undergo ISBCS appeared to be influenced by surgeon recommendation in clinic. Forty percent (6/15) of participants listed for ISBCS perceived that they were recommended it, while only 8% (1/12) of the surgery-naive participants that chose not to be listed for ISBCS perceived they were recommended it. A possible explanation is that since ISBCS is controversial, unconscious personal biases held by surgeons may cause patients to be persuaded either in favour or against ISBCS [7]. Nonetheless, it was encouraging that most participants offered ISBCS (70%) felt that the surgeon offered both choices equally and did not express any preference.

ISBCS is often considered a riskier surgical option than DSBCS, mainly due to concerns regarding complications such as bilateral endophthalmitis [3]. Since research suggests that females and older adults tend to be more risk averse, it was anticipated that these patients would be less likely to be willing to undergo ISBCS [19]. However, there was no significant statistical difference (p > 0.3) between the age and sex of participants that would and would not choose ISBCS. As demonstrated by the diverse list of reasons given by participants in Tables 2 and 3, this may be because decisions regarding ISBCS are highly dependent on individual circumstances. Thus, the decision-making process cannot be easily reduced to patient demographics.

The most popular response in favour of ISBCS was convenience or to save time and travel as there would be fewer hospital visits. It has been estimated that ISBCS requires two fewer hospital appointments than DSBCS [6]. Since most cataract patients are older adults, many of whom have reduced visual function or fragilities, additional travel to and from hospital is often a significant undertaking requiring support from carers and family members. It may also incur further economic costs due to time off work and travel expenses [5, 6].

The risk of complications in both eyes and concerns about safety were reported by over half (54%) of participants that expressed concerns regarding ISBCS. Many ophthalmologists share these concerns with a recent survey finding the risk of bilateral endophthalmitis as the main reason for surgeons deciding not to perform ISBCS in the UK [7]. In clinical practice, the estimated risk of bilateral endophthalmitis typically quoted to patients is “1/250 000” [20]. However, since no cases of bilateral endophthalmitis have been reported following ISBCS adhering to aseptic protocol, it remains a theoretical risk [10].

Another common concern regarding ISBCS is that it removes the opportunity for refractive outcome refinement in the second eye based on outcomes in the first eye [7]. Large case series and randomised controlled trials have not substantiated these fears, and report similar refractive and visual function outcomes for ISBCS and DSBCS [8, 9, 21].

Although fear is a well-recognised barrier to uptake of ISCBS, the role of other related emotions such as anxiety and stress in ISBCS decision-making are relatively unexplored [13]. Anxiety and stress were common motivators for uptake with approximately a quarter (28%) of participants in favour of ISBCS wishing to undergo ISBCS to avoid the anxiety or stress of an additional operation or hospital appointment.

Of the post-operative responses against ISBCS, 4% included concerns regarding the operation length or the need to lie flat for a long time. An additional 4% felt that ISBCS is undesirable as it would be more uncomfortable. Although these were uncommon concerns in our study, this supports previous research suggesting that ISBCS may be less appropriate for patients anxious about undergoing a lengthy operation or those with difficulty lying flat [3].

One advantage of ISBCS is that it avoids suboptimum visual acuity between surgeries as both cataracts are removed in one sitting [11]. Of the participants that gave reasons in favour of ISBCS, 30% of surgery-naive participants and 17% of post-operative participants would undergo ISBCS to improve their eyesight more quickly. The higher rates amongst surgery-naive participants may represent a greater eagerness of patients with visually significant cataracts to restore their quality of life via ISBCS.

Anisometropia is often experienced between surgeries in DSBCS [11]. Of the respondents in favour of ISBCS, 12.1% of surgery-naive participants and 37.0% of post-operative participants reported that they would choose ISBCS to avoid issues associated with visual imbalance. In addition, 4.3% of the responses given by post-operative participants in favour of ISBCS mentioned the avoided expense of additional spectacles or a blank spectacle lens. The three-fold higher proportion of post-operative participants that cited difficulties related to anisometropia suggests that, although this is an important motivator for patients choosing ISBCS, patients only become aware of these issues after undergoing cataract surgery. Given that certain patients, such as high myopes and hyperopes, are at particular risk of anisometropia during DSBCS, this should be a consideration when counselling these patients.

Concerns related to the ISBCS recovery period were a common barrier to uptake. Amongst respondents that reported reasons against choosing ISBCS, around a third (34%) mentioned concerns regarding coping with visual impairment in both eyes while eyes recover. While this is understandable and some degree of additional support may be required in the immediate hours after surgery, the implicit worry that ISBCS will leave patients debilitated for long periods of time is not substantiated. As demonstrated by the quotes given by the post-operative ISBCS patients in Fig. 1, recovery of visual function following ISBCS can be very quick, which is often unexpected by patients.

Another common misunderstanding amongst participants regarding the ISBCS recovery period was the need to wear patches that obscure both eyes. It is likely that this misunderstanding has arisen as post-operative patients sometimes wear opaque dressings following unilateral cataract surgery with sub-tenons anaesthesia. Although the fear of wearing patches on both eyes following ISBCS is reasonable, as this would leave participants with no visual perception, it is avoided in ISBCS, as patients have topical anaesthesia and clear shields placed after surgery.

Given that the mean age of the study population is over 70 years, it is unsurprising that a majority (67.8%) reported to be retired. This may explain why relatively few (9%) of the participants would choose ISBCS to reduce time off work. Overall, there was no significant statistical difference (p = 0.62) found in employment status between participants that would and would not undergo ISBCS. While this is perhaps unexpected due to the emphasis placed on lost worktime in prior ISBCS economic analysis, this is consistent with previous patient attitude surveys [5, 6, 13].

Cataract service delays were a common concern during the pandemic [22]. Although we are moving into a post-COVID-19 era and services are catching up, a residual cataract backlog exists and the demand for cataract surgery continues to grow [1, 2]. Since ISBCS is known to improve the efficiency and cost-effectiveness of cataract services, increasing its practice would offer significant benefits [4-6]. This is reflected in the responses given by participants in favour of ISBCS with over a quarter (28%) reporting that they would opt for ISBCS to reduce the wait for surgery and 9% reporting that ISBCS would benefit the NHS. Although the desire to undergo ISBCS to reduce waiting time may be exaggerated in our study due to COVID-19 related delays, the need to reduce waiting lists and optimise services remains of paramount importance to ensure the sustainability of NHS cataract services.

This cross-sectional study suggests that significantly more NHS cataract patients would opt for ISBCS if given the choice. Given the need for more efficient NHS cataract services, this is promising, and suggests that service redesign proposals to increase the practice of ISBCS are possible. However, for this to be realised in clinical practice, patient barriers to uptake of ISBCS, such as misunderstandings about the recovery period, must first be addressed. In addition, our data suggests that ophthalmic surgeons and clinic staff have substantial influence in facilitating patients to undergo ISBCS, both as sources of information about the surgery and as counsellors in clinic. Thus, it may be that patients will only be offered and accept ISBCS at scale once ophthalmic surgeons become convinced that ISBCS is in their patients’ best interests.

Summary

What was known before

ISBCS is recommended by NICE [NG77] for consideration of offering to the majority of cataract patients.

Fewer than 1% of cataract operations performed in the NHS were ISBCS in 2018/19.

A survey undertaken at the start of the COVID-19 pandemic found that 45% of patients on NHS cataract surgery waiting lists would opt for ISBCS if offered it.

What this study adds

As the post-pandemic recovery continues, ISBCS may have a role to play with over a third of bilateral cataract patients indicating that they would opt for ISBCS if given a choice.

Less than half of cataract patients are aware that ISBCS is an option, and eye clinic staff were the main reported source of information for those who were aware of it.

Patient misunderstandings and surgeon preferences are common barriers to patients undergoing ISBCS in the NHS.