Literature DB >> 35857918

Apparent anomalous diffusion and non-Gaussian distributions in a simple mobile-immobile transport model with Poissonian switching.

Timo J Doerries1, Aleksei V Chechkin1,2,3, Ralf Metzler1.   

Abstract

We analyse mobile-immobile transport of particles that switch between the mobile and immobile phases with finite rates. Despite this seemingly simple assumption of Poissonian switching, we unveil a rich transport dynamics including significant transient anomalous diffusion and non-Gaussian displacement distributions. Our discussion is based on experimental parameters for tau proteins in neuronal cells, but the results obtained here are expected to be of relevance for a broad class of processes in complex systems. Specifically, we obtain that, when the mean binding time is significantly longer than the mean mobile time, transient anomalous diffusion is observed at short and intermediate time scales, with a strong dependence on the fraction of initially mobile and immobile particles. We unveil a Laplace distribution of particle displacements at relevant intermediate time scales. For any initial fraction of mobile particles, the respective mean squared displacement (MSD) displays a plateau. Moreover, we demonstrate a short-time cubic time dependence of the MSD for immobile tracers when initially all particles are immobile.

Entities:  

Keywords:  diffusion; mobile–immobile model; tau proteins

Mesh:

Year:  2022        PMID: 35857918      PMCID: PMC9257594          DOI: 10.1098/rsif.2022.0233

Source DB:  PubMed          Journal:  J R Soc Interface        ISSN: 1742-5662            Impact factor:   4.293


  34 in total

1.  Analysis of binding reactions by fluorescence recovery after photobleaching.

Authors:  Brian L Sprague; Robert L Pego; Diana A Stavreva; James G McNally
Journal:  Biophys J       Date:  2004-06       Impact factor: 4.033

2.  Intermittent molecular hopping at the solid-liquid interface.

Authors:  Michael J Skaug; Joshua Mabry; Daniel K Schwartz
Journal:  Phys Rev Lett       Date:  2013-06-20       Impact factor: 9.161

3.  Langevin equation with fluctuating diffusivity: A two-state model.

Authors:  Tomoshige Miyaguchi; Takuma Akimoto; Eiji Yamamoto
Journal:  Phys Rev E       Date:  2016-07-08       Impact factor: 2.529

4.  Three distinct axonal transport rates for tau, tubulin, and other microtubule-associated proteins: evidence for dynamic interactions of tau with microtubules in vivo.

Authors:  M Mercken; I Fischer; K S Kosik; R A Nixon
Journal:  J Neurosci       Date:  1995-12       Impact factor: 6.167

Review 5.  Microinjection of fluorescently labeled proteins into living cells with emphasis on cytoskeletal proteins.

Authors:  T E Kreis; W Birchmeier
Journal:  Int Rev Cytol       Date:  1982

6.  Single-Molecule Imaging Reveals that Rad4 Employs a Dynamic DNA Damage Recognition Process.

Authors:  Muwen Kong; Lili Liu; Xuejing Chen; Katherine I Driscoll; Peng Mao; Stefanie Böhm; Neil M Kad; Simon C Watkins; Kara A Bernstein; John J Wyrick; Jung-Hyun Min; Bennett Van Houten
Journal:  Mol Cell       Date:  2016-10-06       Impact factor: 17.970

7.  A single-molecule characterization of p53 search on DNA.

Authors:  Anahita Tafvizi; Fang Huang; Alan R Fersht; Leonid A Mirny; Antoine M van Oijen
Journal:  Proc Natl Acad Sci U S A       Date:  2010-12-22       Impact factor: 11.205

8.  Single-molecule dynamics of enhanceosome assembly in embryonic stem cells.

Authors:  Jiji Chen; Zhengjian Zhang; Li Li; Bi-Chang Chen; Andrey Revyakin; Bassam Hajj; Wesley Legant; Maxime Dahan; Timothée Lionnet; Eric Betzig; Robert Tjian; Zhe Liu
Journal:  Cell       Date:  2014-03-13       Impact factor: 41.582

9.  Cusp of Non-Gaussian Density of Particles for a Diffusing Diffusivity Model.

Authors:  M Hidalgo-Soria; E Barkai; S Burov
Journal:  Entropy (Basel)       Date:  2021-02-17       Impact factor: 2.524

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