Literature DB >> 3585730

Solubility and partitioning. VII: Solubility of barbiturates in water.

R Pinal, S H Yalkowsky.   

Abstract

The solubility equation of Yalkowsky was used to estimate the aqueous solubility of 33 barbiturates in the temperature range of 5 to 45 degrees C. The equation was extended by adding a term which accounts for the effect of pH on the solubility of the drug. The extended equation is successful in estimating the aqueous solubility of this series of drugs under different conditions of temperature and pH. The results indicate that the extended equation can be used to estimate the aqueous solubility of nonelectrolytes as well as weak electrolytes.

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Year:  1987        PMID： 3585730     DOI： 10.1002/jps.2600760120

Source DB:  PubMed          Journal:  J Pharm Sci        ISSN： 0022-3549            Impact factor:   3.534


  4 in total

1.  Quantitative structure-pharmacokinetics relationships: II. A mechanistically based model to evaluate the relationship between tissue distribution parameters and compound lipophilicity.

Authors:  I Nestorov; L Aarons; M Rowland
Journal:  J Pharmacokinet Biopharm       Date:  1998-10

2.  Cocrystal Solubility Product Prediction Using an in combo Model and Simulations to Improve Design of Experiments.

Authors:  Alex Avdeef
Journal:  Pharm Res       Date:  2018-02-02       Impact factor: 4.200

3.  Aqueous and cosolvent solubility data for drug-like organic compounds.

Authors:  Erik Rytting; Kimberley A Lentz; Xue-Qing Chen; Feng Qian; Srini Vakatesh
Journal:  AAPS J       Date:  2005-04-26       Impact factor: 4.009

4.  Quantitative structure-pharmacokinetics relationships: I. Development of a whole-body physiologically based model to characterize changes in pharmacokinetics across a homologous series of barbiturates in the rat.

Authors:  G E Blakey; I A Nestorov; P A Arundel; L J Aarons; M Rowland
Journal:  J Pharmacokinet Biopharm       Date:  1997-06
  4 in total

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