Literature DB >> 35854021

Suppression of PI3K/Akt/mTOR Signaling Pathway and Antioxidant System and Reversal of Cancer Cells Resistance to Cisplatin under the Effect of Curcumin.

E V Kalinina1, A A Sh Hasan2, V V Tatarskiy3, Yu L Volodina3, А S Petrova3, M D Novichkova2, D D Zhdanov2, N K Nurmuradov2, N N Chernov2, A A Shtil3.   

Abstract

The effect of curcumin on the resistance of SKOV-3 human ovarian adenocarcinoma cells to cisplatin was studied. It was found that curcumin induced "reversal" of cancer cells resistance, which was associated with suppression of the expression of genes encoding the key antioxidant enzymes (SOD1, SOD2, CAT, GPX1, and HO-1) and transcription factor Nrf2 and a decrease in the expression of genes encoding kinases of the PI3K/Akt/mTOR signaling pathway. The obtained results confirm the role of redox-dependent regulation in the "reversal" of cancer cells resistance to cisplatin.
© 2022. Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  PI3K/AkT/mTOR signaling pathway; cisplatin; gene expression; tumor cells drug resistance

Mesh：

Substances：

Year:  2022        PMID： 35854021     DOI： 10.1007/s10517-022-05551-x

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.737


  10 in total

1.  Reactive oxygen species generation is essential for cisplatin-induced accelerated senescence in hepatocellular carcinoma.

Authors:  Kai Qu; Ting Lin; Zhixin Wang; Sinan Liu; Hulin Chang; Xinsen Xu; Fandi Meng; Lei Zhou; Jichao Wei; Minghui Tai; Yafeng Dong; Chang Liu
Journal:  Front Med       Date:  2014-04-22       Impact factor: 4.592

Review 2.  Nrf2-Keap1 signaling in oxidative and reductive stress.

Authors:  Ilaria Bellezza; Ileana Giambanco; Alba Minelli; Rosario Donato
Journal:  Biochim Biophys Acta Mol Cell Res       Date:  2018-02-27       Impact factor: 4.739

3.  Basic Colorimetric Proliferation Assays: MTT, WST, and Resazurin.

Authors:  Konstantin Präbst; Hannes Engelhardt; Stefan Ringgeler; Holger Hübner
Journal:  Methods Mol Biol       Date:  2017

4.  Apoptotic Endonuclease EndoG Inhibits Telomerase Activity and Induces Malignant Transformation of Human CD4+ T Cells.

Authors:  D A Vasina; D D Zhdanov; E V Orlova; V S Orlova; M V Pokrovskaya; S S Aleksandrova; N N Sokolov
Journal:  Biochemistry (Mosc)       Date:  2017-01       Impact factor: 2.487

5.  Redox-Dependent Expression of Genes Encoding NADPH Oxidase 5 and the Key Antioxidant Enzymes during Formation of Drug Resistance of Tumor Cells to Cisplatin.

Authors:  E V Kalinina; Y A Andreev; A S Petrova; K I Lubova; A A Shtil'; N N Chernov; M D Novichkova; N K Nurmuradov
Journal:  Bull Exp Biol Med       Date:  2018-09-17       Impact factor: 0.804

Review 6.  Role of PI3K-AKT-mTOR Pathway as a Pro-Survival Signaling and Resistance-Mediating Mechanism to Therapy of Prostate Cancer.

Authors:  Thanakorn Pungsrinont; Julia Kallenbach; Aria Baniahmad
Journal:  Int J Mol Sci       Date:  2021-10-14       Impact factor: 5.923

Review 7.  Phosphoinositide 3-Kinase/Akt Signaling and Redox Metabolism in Cancer.

Authors:  Nikos Koundouros; George Poulogiannis
Journal:  Front Oncol       Date:  2018-05-15       Impact factor: 6.244

8.  Inhibition of PI3K/AKT signaling via ROS regulation is involved in Rhein-induced apoptosis and enhancement of oxaliplatin sensitivity in pancreatic cancer cells.

Authors:  Yuhui Liu; Chengjian Shi; Zheng He; Feng Zhu; Min Wang; Ruizhi He; Chunle Zhao; Xiuhui Shi; Min Zhou; Shutao Pan; Yang Gao; Xu Li; Renyi Qin
Journal:  Int J Biol Sci       Date:  2021-01-15       Impact factor: 6.580

Review 9.  Role of PI3K/AKT pathway in cancer: the framework of malignant behavior.

Authors:  Ningni Jiang; Qijie Dai; Xiaorui Su; Jianjiang Fu; Xuancheng Feng; Juan Peng
Journal:  Mol Biol Rep       Date:  2020-04-24       Impact factor: 2.742
  10 in total

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