Literature DB >> 35854020

Effects of Wenyang Zhenshuai Granules on the Expression of Key Mitochondrial Autophagy Proteins in the Doxorubicin-Induced Model of H9c2 Cardiomyocyte Injury.

L Q Peng1, X X Wu2, G Chen3, H Z Cai1, Y P Tang4, Q Y Chen5, X Y Chen6.   

Abstract

This study aimed to explore the effects of Wenyang Zhenshuai granules (WZG) on the morphology of cardiomyocytes, cell viability, and the expression of key mitochondrial autophagy proteins in the doxorubicin-induced model of H9c2 cardiomyocyte injury. Cardiomyocytes were cultured for 44 h and divided into 4 groups: intact control, doxorubicin-injured cells (DOX), doxorubicin-injured cells treated with WZG (DOX+WZG), and doxorubicin-injured cells treated with valsartan (DOX+valsartan; reference group). The morphology of cardiomyocytes was analyzed under an inverted microscope; cardiomyocyte survival rate was determined by MTT assay. The expression of the key mitochondrial autophagy proteins (PINK1, parkin, LC3-II, and prohibitin-2) was analyzed by Western blotting. WZG down-regulated the expression of the key mitochondrial autophagy proteins in DOX-injured cells, which may be one of the important mechanisms for regulating ventricular remodeling and cardiomyocyte apoptosis.
© 2022. Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  Wenyang Zhenshuai granules; cardiomyocyte; chronic heart failure; key mitochondrial autophagy proteins

Mesh：

Substances：

Year:  2022        PMID： 35854020     DOI： 10.1007/s10517-022-05545-9

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.737


  11 in total

1.  Prohibitin 2 Is an Inner Mitochondrial Membrane Mitophagy Receptor.

Authors:  Yongjie Wei; Wei-Chung Chiang; Rhea Sumpter; Prashant Mishra; Beth Levine
Journal:  Cell       Date:  2016-12-22       Impact factor: 41.582

Review 2.  Mitophagy in cardiovascular disease.

Authors:  Hong Zhou; Lu He; Gaosheng Xu; Linxi Chen
Journal:  Clin Chim Acta       Date:  2020-05-01       Impact factor: 3.786

Review 3.  Mechanisms of mitophagy: PINK1, Parkin, USP30 and beyond.

Authors:  Baris Bingol; Morgan Sheng
Journal:  Free Radic Biol Med       Date:  2016-04-16       Impact factor: 7.376

4.  Effects of Wenyangzhenshuai Granule on ERK1/2 and ERK5 activity in the myocardial tissue in a rabbit model of adriamycin-induced chronic heart failure.

Authors:  Xinyu Chen; Huzhi Cai; Qingyang Chen; Haibo Xie; Yuemei Liu; Qing Lu; Yanping Tang
Journal:  Int J Clin Exp Med       Date:  2015-11-15

5.  Duration of chronic heart failure affects outcomes with preserved effects of heart rate reduction with ivabradine: findings from SHIFT.

Authors:  Michael Böhm; Michel Komajda; Jeffrey S Borer; Ian Ford; Christoph Maack; Luigi Tavazzi; Aurélie Moyne; Karl Swedberg
Journal:  Eur J Heart Fail       Date:  2017-10-12       Impact factor: 15.534

6.  Protective effect of lncRNA CRNDE on myocardial cell apoptosis in heart failure by regulating HMGB1 cytoplasm translocation through PARP-1.

Authors:  Hui Chen; Jinming Liu; Bin Wang; Yongjun Li
Journal:  Arch Pharm Res       Date:  2020-11-29       Impact factor: 4.946

7.  Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65.

Authors:  Agne Kazlauskaite; Chandana Kondapalli; Robert Gourlay; David G Campbell; Maria Stella Ritorto; Kay Hofmann; Dario R Alessi; Axel Knebel; Matthias Trost; Miratul M K Muqit
Journal:  Biochem J       Date:  2014-05-15       Impact factor: 3.857

8.  Cardiac-specific Conditional Knockout of the 18-kDa Mitochondrial Translocator Protein Protects from Pressure Overload Induced Heart Failure.

Authors:  Phung N Thai; Daniel J Daugherty; Bert J Frederich; Xiyuan Lu; Wenbin Deng; Donald M Bers; Elena N Dedkova; Saul Schaefer
Journal:  Sci Rep       Date:  2018-11-01       Impact factor: 4.379
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