| Literature DB >> 35851442 |
Yang Zheng1, Gábor Wágner1, Niels Hauwert1, Xiaoyuan Ma1, Henry F Vischer1, Rob Leurs2.
Abstract
The histamine research community has in the last decade been very active and generated a number of exciting new chemical biology tools for the study of histamine receptors, their ligands, and their pharmacology. In this paper we describe the development of histamine receptor structural biology, the use of receptor conformational biosensors, and the development of new ligands for covalent or fluorescent labeling or for photopharmacological approaches (photocaging and photoswitching). These new tools allow new approaches to study histamine receptors and hopefully will lead to better insights in the molecular aspects of histamine receptors and their ligands.Entities:
Keywords: Biosensors; Covalent ligands; Fluorescent ligands; Histamine receptor structural biology; Photocaging; Photopharmacology; Photoswitching
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Year: 2022 PMID： 35851442 DOI： 10.1007/7854_2022_360
Source DB: PubMed Journal: Curr Top Behav Neurosci ISSN： 1866-3370