Xuerong Deng1, Xiaoying Sun1, Wenhui Xie1, Yu Wang1, Zhuoli Zhang2. 1. Department of Rheumatology and Clinical Immunology, Peking University First Hospital, No. 8, Xishiku Street, Beijing, 100034, China. 2. Department of Rheumatology and Clinical Immunology, Peking University First Hospital, No. 8, Xishiku Street, Beijing, 100034, China. zhuoli.zhang@126.com.
Abstract
OBJECTIVES: To explore the correlation between the ultrasound-detected synovitis in each individual joint at metacarpophalangeal (MCP), proximal interphalangeal (PIP), and metatarsophalangeal (MTP) regions and the clinical disease activity in patients with rheumatoid arthritis (RA). METHODS: Clinical disease activity was assessed by disease activity score (DAS) based on 28-joint count and erythrocyte sedimentation rate (DAS28-ESR), C-reactive protein (DAS28-CRP), Simplified Disease Activity Index (SDAI), and Clinical Disease Activity Index (CDAI). Gray scale (GS) and power Doppler (PD) synovitis was assessed by ultrasound semi-quantitatively. The correlation between clinical disease activity indices and synovitis score in each joint was assessed using Spearman's rank correlation test. RESULTS: 211 RA patients were included in this study. The whole GS scores of all MCP joints showed the highest correlation with each Clinical Disease Activity Index (r = 0.403-0.452, p < 0.01). Likewise, the whole PD scores of all MCP joints also showed the highest correlation with clinical disease activity (r = 0.332-0.396, p < 0.01). At individual joint level, the highest correlation of GS score with DAS28-ESR (r = 0.411, p < 0.01), DAS28-CRP (r = 0.459, p < 0.01), and SDAI (r = 0.444, p < 0.01) was observed in MCP3 joint while with CDAI (r = 0.421, p < 0.01) in MCP2 joint. The highest correlation of PD score with DAS28-ESR (r = 0.353, p < 0.01), DAS28-CRP (r = 0.399, p < 0.01), CDAI (r = 0.368, p < 0.01), and SDAI (r = 0.377, p < 0.01) was observed in MCP5 joint. CONCLUSIONS: The ultrasound-detected synovitis at MCP joints, especially MCP2, MCP3, and MCP5 joints, was best correlated with clinical disease activity in most RA cases, in contrast to PIP and MTP joints. Key Points • The correlation of ultrasound-detected synovitis in each individual joint with the clinical disease activity in RA patients is diverse among joint regions. MCP joints showed the best, in contrast to PIP and MTP joints.
OBJECTIVES: To explore the correlation between the ultrasound-detected synovitis in each individual joint at metacarpophalangeal (MCP), proximal interphalangeal (PIP), and metatarsophalangeal (MTP) regions and the clinical disease activity in patients with rheumatoid arthritis (RA). METHODS: Clinical disease activity was assessed by disease activity score (DAS) based on 28-joint count and erythrocyte sedimentation rate (DAS28-ESR), C-reactive protein (DAS28-CRP), Simplified Disease Activity Index (SDAI), and Clinical Disease Activity Index (CDAI). Gray scale (GS) and power Doppler (PD) synovitis was assessed by ultrasound semi-quantitatively. The correlation between clinical disease activity indices and synovitis score in each joint was assessed using Spearman's rank correlation test. RESULTS: 211 RA patients were included in this study. The whole GS scores of all MCP joints showed the highest correlation with each Clinical Disease Activity Index (r = 0.403-0.452, p < 0.01). Likewise, the whole PD scores of all MCP joints also showed the highest correlation with clinical disease activity (r = 0.332-0.396, p < 0.01). At individual joint level, the highest correlation of GS score with DAS28-ESR (r = 0.411, p < 0.01), DAS28-CRP (r = 0.459, p < 0.01), and SDAI (r = 0.444, p < 0.01) was observed in MCP3 joint while with CDAI (r = 0.421, p < 0.01) in MCP2 joint. The highest correlation of PD score with DAS28-ESR (r = 0.353, p < 0.01), DAS28-CRP (r = 0.399, p < 0.01), CDAI (r = 0.368, p < 0.01), and SDAI (r = 0.377, p < 0.01) was observed in MCP5 joint. CONCLUSIONS: The ultrasound-detected synovitis at MCP joints, especially MCP2, MCP3, and MCP5 joints, was best correlated with clinical disease activity in most RA cases, in contrast to PIP and MTP joints. Key Points • The correlation of ultrasound-detected synovitis in each individual joint with the clinical disease activity in RA patients is diverse among joint regions. MCP joints showed the best, in contrast to PIP and MTP joints.
Authors: M Backhaus; G R Burmester; T Gerber; W Grassi; K P Machold; W A Swen; R J Wakefield; B Manger Journal: Ann Rheum Dis Date: 2001-07 Impact factor: 19.103
Authors: Daniel Aletaha; Tuhina Neogi; Alan J Silman; Julia Funovits; David T Felson; Clifton O Bingham; Neal S Birnbaum; Gerd R Burmester; Vivian P Bykerk; Marc D Cohen; Bernard Combe; Karen H Costenbader; Maxime Dougados; Paul Emery; Gianfranco Ferraccioli; Johanna M W Hazes; Kathryn Hobbs; Tom W J Huizinga; Arthur Kavanaugh; Jonathan Kay; Tore K Kvien; Timothy Laing; Philip Mease; Henri A Ménard; Larry W Moreland; Raymond L Naden; Theodore Pincus; Josef S Smolen; Ewa Stanislawska-Biernat; Deborah Symmons; Paul P Tak; Katherine S Upchurch; Jirí Vencovsky; Frederick Wolfe; Gillian Hawker Journal: Ann Rheum Dis Date: 2010-09 Impact factor: 19.103
Authors: Marcin Szkudlarek; Michel Court-Payen; Søren Jacobsen; Mette Klarlund; Henrik S Thomsen; Mikkel Østergaard Journal: Arthritis Rheum Date: 2003-04
Authors: Richard J Wakefield; Peter V Balint; Marcin Szkudlarek; Emilio Filippucci; Marina Backhaus; Maria-Antonietta D'Agostino; Esperanza Naredo Sanchez; Annamaria Iagnocco; Wolfgang A Schmidt; George A W Bruyn; George Bruyn; David Kane; Philip J O'Connor; Bernhard Manger; Fred Joshua; Juhani Koski; Walter Grassi; Marissa N D Lassere; Nanno Swen; Franz Kainberger; Andrea Klauser; Mikkel Ostergaard; Andrew K Brown; Klaus P Machold; Philip G Conaghan Journal: J Rheumatol Date: 2005-12 Impact factor: 4.666
Authors: Theresa Kapral; Florian Dernoschnig; Klaus P Machold; Tanja Stamm; Monika Schoels; Josef S Smolen; Daniel Aletaha Journal: Arthritis Res Ther Date: 2007 Impact factor: 5.156
Authors: Thomas Kurien; Robert W Kerslake; Thomas Graven-Nielsen; Lars Arendt-Nielsen; Dorothee P Auer; Kimberley Edwards; Brigitte E Scammell; Kristian Kjaer-Staal Petersen Journal: Eur J Pain Date: 2022-08-19 Impact factor: 3.651