| Literature DB >> 35848942 |
Frauke Degenhardt1, David Ellinghaus1,2, Simonas Juzenas1,3, Jon Lerga-Jaso4, Mareike Wendorff1, Douglas Maya-Miles5,6,7, Florian Uellendahl-Werth1, Hesham ElAbd1, Malte C Rühlemann1,8, Jatin Arora9,10,11,12,13, Onur Özer14,15, Ole Bernt Lenning16,17, Ronny Myhre18, May Sissel Vadla17,19, Eike M Wacker1, Lars Wienbrandt1, Aaron Blandino Ortiz20, Adolfo Salazar21,22, Adolfo Garrido Chercoles23, Adriana Palom24,25, Agustín Ruiz26,27, Alba-Estela Garcia-Fernandez28, Albert Blanco-Grau28, Alberto Mantovani29,30, Alberto Zanella31,32, Aleksander Rygh Holten33,34, Alena Mayer35, Alessandra Bandera31,32, Alessandro Cherubini32, Alessandro Protti29,30, Alessio Aghemo29,30, Alessio Gerussi36,37, Alfredo Ramirez38,39,40,41,42, Alice Braun35, Almut Nebel1, Ana Barreira25, Ana Lleo29,30, Ana Teles14,15, Anders Benjamin Kildal43, Andrea Biondi44, Andrea Caballero-Garralda45, Andrea Ganna46, Andrea Gori32,47, Andreas Glück48, Andreas Lind49, Anja Tanck1, Anke Hinney50, Anna Carreras Nolla51, Anna Ludovica Fracanzani31,32, Anna Peschuck1, Annalisa Cavallero52, Anne Ma Dyrhol-Riise34,53, Antonella Ruello54, Antonio Julià24, Antonio Muscatello32, Antonio Pesenti31,32, Antonio Voza29,30, Ariadna Rando-Segura55,56, Aurora Solier57, Axel Schmidt58, Beatriz Cortes51, Beatriz Mateos6,59, Beatriz Nafria-Jimenez23, Benedikt Schaefer60,61, Björn Jensen62, Carla Bellinghausen63, Carlo Maj64, Carlos Ferrando65,66, Carmen Horra5,7,67,68,69, Carmen Quereda70, Carsten Skurk35, Charlotte Thibeault35, Chiara Scollo71, Christian Herr72, Christoph D Spinner73, Christoph Gassner1,74, Christoph Lange75,76,77, Cinzia Hu78, Cinzia Paccapelo32, Clara Lehmann79,80,81, Claudio Angelini82, Claudio Cappadona30, Clinton Azuure14,15, Cristiana Bianco32, Cristina Cea28, Cristina Sancho83, Dag Arne Lihaug Hoff84,85, Daniela Galimberti31,32, Daniele Prati32, David Haschka86, David Jiménez57, David Pestaña87, David Toapanta66, Eduardo Muñiz-Diaz88, Elena Azzolini29,30, Elena Sandoval66, Eleonora Binatti36,37, Elio Scarpini31,32, Elisa T Helbig35, Elisabetta Casalone89, Eloisa Urrechaga90,91, Elvezia Maria Paraboschi29,30, Emanuele Pontali92, Enric Reverter66, Enrique J Calderón5,7,67,68,69, Enrique Navas70, Erik Solligård93,94, Ernesto Contro95, Eunate Arana-Arri96, Fátima Aziz66, Federico Garcia21,22,97, Félix García Sánchez98, Ferruccio Ceriotti32, Filippo Martinelli-Boneschi99,100, Flora Peyvandi101,102, Florian Kurth35,103, Francesco Blasi104,105, Francesco Malvestiti31, Francisco J Medrano7,67,68,69,106, Francisco Mesonero6,59, Francisco Rodriguez-Frias6,24,56,107, Frank Hanses108,109, Fredrik Müller34,49, Georg Hemmrich-Stanisak1, Giacomo Bellani110,111, Giacomo Grasselli31,32, Gianni Pezzoli112, Giorgio Costantino31,32, Giovanni Albano54, Giulia Cardamone30, Giuseppe Bellelli111,113, Giuseppe Citerio111,114, Giuseppe Foti110,111, Giuseppe Lamorte32, Giuseppe Matullo89, Guido Baselli32, Hayato Kurihara82, Holger Neb115, Ilaria My29, Ingo Kurth116, Isabel Hernández26,27, Isabell Pink117, Itziar Rojas26,27, Iván Galván-Femenia51, Jan Cato Holter34,49, Jan Egil Afset84,118, Jan Heyckendorf75,76,77, Jan Kässens1, Jan Kristian Damås119,120, Jan Rybniker79,80,121, Janine Altmüller122, Javier Ampuero5,6,7,67,123, Javier Martín124, Jeanette Erdmann125,126,127, Jesus M Banales6,128,129, Joan Ramon Badia130, Joaquin Dopazo7,131, Jochen Schneider73, Jonas Bergan132, Jordi Barretina133, Jörn Walter134, Jose Hernández Quero21,135, Josune Goikoetxea136, Juan Delgado5,7,67,68,69, Juan M Guerrero5,7,67, Julia Fazaal58, Julia Kraft35, Julia Schröder58, Kari Risnes120,137, Karina Banasik2, Karl Erik Müller138, Karoline I Gaede139,140,141, Koldo Garcia-Etxebarria6,128, Kristian Tonby34,53, Lars Heggelund138,142, Laura Izquierdo-Sanchez6,128,143, Laura Rachele Bettini44, Lauro Sumoy133, Leif Erik Sander35, Lena J Lippert35, Leonardo Terranova32, Lindokuhle Nkambule144,145, Lisa Knopp62, Lise Tuset Gustad93,146, Lucia Garbarino147, Luigi Santoro32, Luis Téllez6,59, Luisa Roade6,25,56, Mahnoosh Ostadreza32, Maider Intxausti83, Manolis Kogevinas68,148,149,150, Mar Riveiro-Barciela6,25,56, Marc M Berger151, Marco Schaefer152, Mari E K Niemi46, María A Gutiérrez-Stampa153, Maria Carrabba78, Maria E Figuera Basso1, Maria Grazia Valsecchi154, María Hernandez-Tejero66, Maria J G T Vehreschild155, Maria Manunta32, Marialbert Acosta-Herrera124, Mariella D'Angiò44, Marina Baldini32, Marina Cazzaniga156, Marit M Grimsrud34,157,158, Markus Cornberg159, Markus M Nöthen58, Marta Marquié26,27, Massimo Castoldi54, Mattia Cordioli46, Maurizio Cecconi29,30, Mauro D'Amato129,160,161, Max Augustin79,80,81, Melissa Tomasi32, Mercè Boada26,27, Michael Dreher162, Michael J Seilmaier163, Michael Joannidis164, Michael Wittig1, Michela Mazzocco147, Michele Ciccarelli82, Miguel Rodríguez-Gandía6,59, Monica Bocciolone82, Monica Miozzo31,78, Natale Imaz Ayo96, Natalia Blay51, Natalia Chueca22, Nicola Montano31,32, Nicole Braun1,165, Nicole Ludwig166, Nikolaus Marx167, Nilda Martínez168, Oliver A Cornely40,79,81,169, Oliver Witzke170, Orazio Palmieri171, Paola Faverio111,172, Paoletta Preatoni82, Paolo Bonfanti111,173, Paolo Omodei82, Paolo Tentorio29, Pedro Castro66, Pedro M Rodrigues6,128,129,143, Pedro Pablo España90, Per Hoffmann58, Philip Rosenstiel1, Philipp Schommers79,80,81, Phillip Suwalski35, Raúl Pablo20, Ricard Ferrer174, Robert Bals72, Roberta Gualtierotti31,32, Rocío Gallego-Durán5,6,7, Rosa Nieto57, Rossana Carpani32, Rubén Morilla5,7,67,68,69, Salvatore Badalamenti29, Sammra Haider175, Sandra Ciesek176,177, Sandra May1, Sara Bombace29,30, Sara Marsal24, Sara Pigazzini46, Sebastian Klein164, Serena Pelusi31,32, Sibylle Wilfling109,178,179, Silvano Bosari31,32, Sonja Volland180, Søren Brunak2, Soumya Raychaudhuri9,10,11,12,13,181, Stefan Schreiber1,48, Stefanie Heilmann-Heimbach58, Stefano Aliberti29,30, Stephan Ripke35, Susanne Dudman34,49, Tanja Wesse1, Tenghao Zheng182, Thomas Bahmer48, Thomas Eggermann116, Thomas Illig180, Thorsten Brenner151, Tomas Pumarola183,184, Torsten Feldt62, Trine Folseraas34,157,158,185, Trinidad Gonzalez Cejudo186, Ulf Landmesser187, Ulrike Protzer188,189, Ute Hehr178, Valeria Rimoldi30, Valter Monzani32, Vegard Skogen190,191, Verena Keitel62, Verena Kopfnagel180, Vicente Friaza5,7,67,68,69, Victor Andrade38,39, Victor Moreno68,192,193,194, Wolfgang Albrecht1, Wolfgang Peter152,195, Wolfgang Poller35, Xavier Farre51, Xiaoli Yi1, Xiaomin Wang35, Yascha Khodamoradi155, Zehra Karadeniz35, Anna Latiano171, Siegfried Goerg196, Petra Bacher1,197, Philipp Koehler40,79,80, Florian Tran1,48, Heinz Zoller60,61, Eva C Schulte188,198,199, Bettina Heidecker35, Kerstin U Ludwig58, Javier Fernández66,200, Manuel Romero-Gómez5,6,7,67,123, Agustín Albillos6,59, Pietro Invernizzi36,37, Maria Buti6,25,56, Stefano Duga29,30, Luis Bujanda6,128, Johannes R Hov34,157,158,185, Tobias L Lenz14,15, Rosanna Asselta29,30, Rafael Cid51, Luca Valenti31,32, Tom H Karlsen34,157,158,185, Mario Cáceres4,201, Andre Franke1,202.
Abstract
Given the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a deeper analysis of the host genetic contribution to severe COVID-19 is important to improve our understanding of underlying disease mechanisms. Here, we describe an extended GWAS meta-analysis of a well-characterized cohort of 3255 COVID-19 patients with respiratory failure and 12 488 population controls from Italy, Spain, Norway and Germany/Austria, including stratified analyses based on age, sex and disease severity, as well as targeted analyses of chromosome Y haplotypes, the human leukocyte antigen (HLA) region and the SARS-CoV-2 peptidome. By inversion imputation, we traced a reported association at 17q21.31 to a ~ 0.9-Mb inversion polymorphism that creates two highly differentiated haplotypes and characterized the potential effects of the inversion in detail. Our data, together with the 5th release of summary statistics from the COVID-19 Host Genetics Initiative including non-Caucasian individuals, also identified a new locus at 19q13.33, including NAPSA, a gene which is expressed primarily in alveolar cells responsible for gas exchange in the lung.Entities:
Year: 2022 PMID： 35848942 DOI： 10.1093/hmg/ddac158
Source DB: PubMed Journal: Hum Mol Genet ISSN： 0964-6906 Impact factor: 5.121