Literature DB >> 35848116

Disulfiram's journey from rubber vulcanization to T-cell activation.

Magalie Dosset1, Maurizio Zanetti1.   

Abstract

Disulfiram, a drug prescribed for the treatment of alcohol use disorders for more than 60 years, has recently been repurposed for cancer treatment. New work in The EMBO Journal now describes a disulfiram role in immunotherapy of cancer, involving direct binding to Lck to mediate activation of tumor-infiltrating T cells.
© 2022 The Authors.

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Year:  2022        PMID： 35848116      PMCID： PMC9379543          DOI： 10.15252/embj.2022111862

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   14.012


  13 in total

1.  De novo phosphorylation and conformational opening of the tyrosine kinase Lck act in concert to initiate T cell receptor signaling.

Authors:  Lars Philipsen; Amarendra V Reddycherla; Roland Hartig; Janine Gumz; Matthias Kästle; Andreas Kritikos; Mateusz P Poltorak; Yury Prokazov; Evgeny Turbin; André Weber; Werner Zuschratter; Burkhart Schraven; Luca Simeoni; Andreas J Müller
Journal:  Sci Signal       Date:  2017-01-17       Impact factor: 8.192

2.  Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells.

Authors:  Esther A Obeng; Louise M Carlson; Delia M Gutman; William J Harrington; Kelvin P Lee; Lawrence H Boise
Journal:  Blood       Date:  2006-02-28       Impact factor: 22.113

3.  CD4 and CD8 binding to MHC molecules primarily acts to enhance Lck delivery.

Authors:  Maxim N Artyomov; Mieszko Lis; Srinivas Devadas; Mark M Davis; Arup K Chakraborty
Journal:  Proc Natl Acad Sci U S A       Date:  2010-09-13       Impact factor: 11.205

4.  Nonprofit drugs as the salvation of the world's healthcare systems: the case of Antabuse (disulfiram).

Authors:  Boris Cvek
Journal:  Drug Discov Today       Date:  2011-12-16       Impact factor: 7.851

Review 5.  Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation.

Authors:  Emil H Palacios; Arthur Weiss
Journal:  Oncogene       Date:  2004-10-18       Impact factor: 9.867

Review 6.  T-cell receptor proximal signaling via the Src-family kinases, Lck and Fyn, influences T-cell activation, differentiation, and tolerance.

Authors:  Robert J Salmond; Andrew Filby; Ihjaaz Qureshi; Stefano Caserta; Rose Zamoyska
Journal:  Immunol Rev       Date:  2009-03       Impact factor: 12.988

7.  Lck bound to coreceptor is less active than free Lck.

Authors:  Qianru Wei; Joanna Brzostek; Shvetha Sankaran; Javier Casas; Lois Shi-Qi Hew; Jiawei Yap; Xiang Zhao; Lukasz Wojciech; Nicholas R J Gascoigne
Journal:  Proc Natl Acad Sci U S A       Date:  2020-06-22       Impact factor: 11.205

8.  Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains.

Authors:  Yihong Ye; Hemmo H Meyer; Tom A Rapoport
Journal:  J Cell Biol       Date:  2003-07-07       Impact factor: 10.539

9.  Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4.

Authors:  Zdenek Skrott; Martin Mistrik; Klaus Kaae Andersen; Søren Friis; Dusana Majera; Jan Gursky; Tomas Ozdian; Jirina Bartkova; Zsofia Turi; Pavel Moudry; Marianne Kraus; Martina Michalova; Jana Vaclavkova; Petr Dzubak; Ivo Vrobel; Pavla Pouckova; Jindrich Sedlacek; Andrea Miklovicova; Anne Kutt; Jing Li; Jana Mattova; Christoph Driessen; Q Ping Dou; Jørgen Olsen; Marian Hajduch; Boris Cvek; Raymond J Deshaies; Jiri Bartek
Journal:  Nature       Date:  2017-12-06       Impact factor: 49.962

10.  Mathematical modeling identifies Lck as a potential mediator for PD-1 induced inhibition of early TCR signaling.

Authors:  Theinmozhi Arulraj; Debashis Barik
Journal:  PLoS One       Date:  2018-10-24       Impact factor: 3.240
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