Rajabi Mona1,2, Ommi Davood3, Zali Alireza4, Arefian Noor Mohammad5. 1. Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 2. Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran. 3. Functional Neurosurgery Research Center, Shahid Beheshti Medical University, Tehran, Iran. 4. Functional Neurosurgery Research Center, Shohada Tajrish Neurosurgical Center of Excellence, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 5. Anesthesiology Department, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Abstract
BACKGROUND: Postoperative nausea and vomiting (PONV) and shivering are common general anesthesia complications. Hence, this study evaluates the effect of dexmedetomidine, given as a premedication, on PONV and shivering in patients with opium use who underwent elective supratentorial brain tumor surgeries. MATERIALS AND METHODS: In a randomized clinical trial, 100 opium user patients who were candidates for elective supra-tentorial brain tumor surgery under general anesthesia were studied in two groups of 50 patients. The intervention group received dexmedetomidine (within 10 minutes infusion) 30 minutes before the anesthesia induction. Group placebo that received normal saline as a group. PONV and shivering rates were compared between the two groups. RESULTS: Both groups did not differ in hemodynamic parameters during operation, including pulse rate, systolic and diastolic blood pressure, and anesthesia duration. In the dexmedetomidine group, patients suffered less from PONV and shivering rather than controls, and these differences were both significant (P=0.001 and P=0.027, respectively). CONCLUSION: Dexmedetomidine administration before major surgeries might reduce post-operative nausea and vomiting and the occurrence of shivering, particularly in opium-addicted patients. Copyright
BACKGROUND: Postoperative nausea and vomiting (PONV) and shivering are common general anesthesia complications. Hence, this study evaluates the effect of dexmedetomidine, given as a premedication, on PONV and shivering in patients with opium use who underwent elective supratentorial brain tumor surgeries. MATERIALS AND METHODS: In a randomized clinical trial, 100 opium user patients who were candidates for elective supra-tentorial brain tumor surgery under general anesthesia were studied in two groups of 50 patients. The intervention group received dexmedetomidine (within 10 minutes infusion) 30 minutes before the anesthesia induction. Group placebo that received normal saline as a group. PONV and shivering rates were compared between the two groups. RESULTS: Both groups did not differ in hemodynamic parameters during operation, including pulse rate, systolic and diastolic blood pressure, and anesthesia duration. In the dexmedetomidine group, patients suffered less from PONV and shivering rather than controls, and these differences were both significant (P=0.001 and P=0.027, respectively). CONCLUSION: Dexmedetomidine administration before major surgeries might reduce post-operative nausea and vomiting and the occurrence of shivering, particularly in opium-addicted patients. Copyright
Authors: Tong J Gan; Tricia Meyer; Christian C Apfel; Frances Chung; Peter J Davis; Steve Eubanks; Anthony Kovac; Beverly K Philip; Daniel I Sessler; James Temo; Martin R Tramèr; Mehernoor Watcha Journal: Anesth Analg Date: 2003-07 Impact factor: 5.108
Authors: O Panzer; N Ghazanfari; D I Sessler; Y Yücel; M Greher; O Akça; A Donner; P Germann; A Kurz Journal: Anesthesiology Date: 1999-06 Impact factor: 7.892