Literature DB >> 3584394

Significance of hepatic triglyceride lipase activity in the regulation of serum high density lipoproteins in type II diabetes mellitus.

S E Kasim, K Tseng, K L Jen, S Khilnani.   

Abstract

We investigated the regulation of serum high density lipoprotein (HDL) cholesterol metabolism in patients with type II diabetes mellitus by determining the activities of the two lipolytic enzymes that play major roles in the production and degradation of HDL. The activity of lipoprotein lipase (LPL), the enzyme responsible for HDL cholesterol production, and the activity of hepatic triglyceride lipase (HTGL), the enzyme that facilitates the catabolism of HDL, were measured in plasma obtained after iv injection of heparin. Thirty patients were selected to represent a wide range of serum HDL cholesterol concentrations (low, normal, and high HDL cholesterol groups). Mean lipoprotein lipase activity was similar in all three groups [122 +/- 10 (SEM) U/mL in the low HDL, 141 +/- 11 U/mL in the normal HDL, and 148 +/- 30 U/mL in the high HDL group]. Mean HTGL activity was markedly decreased in the high HDL group; the mean values were 346 +/- 28 U/mL in the low HDL, 320 +/- 25 U/mL in the normal HDL, and 191 +/- 23 U/mL in the high HDL groups, respectively. Body weight and insulin requirement correlated directly with HTGL activity and inversely with serum HDL cholesterol levels. These findings suggest that in type II diabetes mellitus low serum HDL cholesterol levels may be due to an increased rate of clearance by HTGL.

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Year:  1987        PMID: 3584394     DOI: 10.1210/jcem-65-1-183

Source DB:  PubMed          Journal:  J Clin Endocrinol Metab        ISSN: 0021-972X            Impact factor:   5.958


  6 in total

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Journal:  J Clin Med Res       Date:  2016-03-20

Review 2.  Diabetic dyslipidemia: evaluation and mechanism.

Authors:  Hidekatsu Yanai; Yuji Hirowatari; Hiroshi Yoshida
Journal:  Glob Health Med       Date:  2019-10-31

3.  Changes of lipolytic enzymes cluster with insulin resistance syndrome. Botnia Study Group.

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Journal:  Diabetologia       Date:  1995-03       Impact factor: 10.122

Review 4.  Diabetic dyslipidaemia: from basic research to clinical practice.

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Journal:  Diabetologia       Date:  2003-05-28       Impact factor: 10.122

5.  Beneficial effects of cocoa, coffee, green tea, and garcinia complex supplement on diet induced obesity in rats.

Authors:  Chi-Chang Huang; Yu-Tang Tung; Wen-Ching Huang; Yi-Ming Chen; Yi-Ju Hsu; Mei-Chich Hsu
Journal:  BMC Complement Altern Med       Date:  2016-03-12       Impact factor: 3.659

Review 6.  Molecular Biological and Clinical Understanding of the Statin Residual Cardiovascular Disease Risk and Peroxisome Proliferator-Activated Receptor Alpha Agonists and Ezetimibe for Its Treatment.

Authors:  Hidekatsu Yanai; Hiroki Adachi; Mariko Hakoshima; Hisayuki Katsuyama
Journal:  Int J Mol Sci       Date:  2022-03-22       Impact factor: 5.923

  6 in total

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