| Literature DB >> 35842711 |
Tommi Vasankari1,2, Jari Halonen3, Sini Vasankari4, Juha Hartikainen3, Ville Vasankari5, Vesa Anttila6, Kari Tokola1, Henri Vähä-Ypyä1, Pauliina Husu1, Harri Sievänen1.
Abstract
BACKGROUND: We investigated preoperative physical activity (PA) and sedentary behaviour (SB) in patients scheduled for elective cardiac procedures and compared them with population-based sample of Finnish adults.Entities:
Keywords: Accelerometry; Aortic valve stenosis; Coronary artery disease; Mitral valve insufficiency; Physical activity; Sedentary behavior
Year: 2022 PMID: 35842711 PMCID: PMC9287962 DOI: 10.1186/s13102-022-00522-1
Source DB: PubMed Journal: BMC Sports Sci Med Rehabil ISSN: 2052-1847
Fig. 1Study participation flow diagram. CABG: coronary artery bypass grafting; AVR: aortic valve replacement; MVS: mitral valve surgery; PCI-CA: percutaneous coronary intervention or coronary angiography
Characteristics of the patients
| CABG (n = 8–24) | AVR (n = 22–49) | MVS (n = 22–51) | PCI-CA (n = 28–68) | p-value | |
|---|---|---|---|---|---|
| Age (y) | 65.4 (6.5) | 63.0 (11.4) | 60.4 (11.3) | 66.0 (6.2) | 0.056 |
| Male* | 17 (70.8) | 35 (71.4) | 44 (86.3) | 47 (69.1) | 0.14 |
| BMI (kg/m2) | 30.0 (4.7) | 28.5 (5.2) | 26.6 (4.6) | 27.5 (4.0) | 0.021 |
| Systolic blood pressure (mmHg) | 136.0 (13.5) | 137.3 (17.3) | 138.8 (12.8) | 141.0 (16.6) | 0.69 |
| Diastolic blood pressure (mmHg) | 79.2 (11.6) | 73.6 (13.9) | 81.3 (9.1) | 88.9 (74.2) | 0.077 |
| Total cholesterol (mmol/l) | 3.7 (0.9) | 4.0 (0.9) | 4.4 (1.0) | 3.9 (1.1) | 0.048 |
| HDL cholesterol (mmol/l) | 1.33 (0.27) | 1.50 (0.32) | 1.47 (0.32) | 1.39 (0.45) | 0.16 |
| LDL cholesterol (mmol/l) | 2.12 (0.86) | 2.40 (0.77) | 2.80 (1.03) | 2.21 (0.96) | 0.032 |
| Triglycerides (mmol/l) | 1.05 (0.39) | 1.01 (0.40) | 1.21 (0.50) | 1.41 (0.87) | 0.13 |
| Smoking* | 1 (4.2) | 1 (2.2) | 1 (2.0) | 3 (4.5) | 0.80 |
| Diabetes* | 15 (62.5) | 10 (21.3) | 2 (3.9) | 18 (26.9) | < 0.001 |
| Hypertension* | 22 (91.7) | 27 (57.4) | 19 (38.0) | 45 (68.2) | < 0.001 |
| Hypercholesterolemia* | 21 (87.5) | 30 (66.7) | 34 (68.0) | 63 (94.0) | 0.002 |
| Atrial fibrillation* | 3 (13.6) | 9 (20.0) | 10 (19.6) | 8 (12.3) | 0.59 |
| Heart failure* | 0 | 2 (4.3) | 2 (3.9) | 1 (1.5) | 0.69 |
| Coronary artery disease* | 24 (100) | 14 (29.8) | 15 (29.4) | 52 (77.6) | < 0.001 |
| Arteriosclerosis obliterans* | 2 (8.3) | 0 | 0 | 0 | 0.016 |
| Stroke or transient ischemic attack* | 2 (8.3) | 4 (8.5) | 3 (5.9) | 4 (6.1) | 0.89 |
| Myocardial infarction* | 6 (25.0) | 0 | 0 | 10 (15.4) | < 0.001 |
| Previous percutaneous coronary intervention* | 9 (37.5) | 4 (8.5) | 3 (5.9) | 21 (31.8) | < 0.001 |
| Previous CABG* | 0 | 0 | 0 | 3 (4.5) | 0.17 |
| Previous valve surgery* | 0 | 2 (4.3) | 2 (3.9) | 1 (1.5) | 0.74 |
| Pacemaker* | 1 (4.2) | 2 (4.3) | 1 (2.0) | 1 (1.5) | 0.64 |
| Lung disease* | 6 (25.0) | 8 (17.4) | 7 (13.7) | 10 (15.2) | 0.63 |
| Cancer* | 0 | 0 | 1 (2.0) | 6 (9.1) | 0.058 |
| Thyroid gland disease* | 2 (8.3) | 2 (4.3) | 1 (2.0) | 8 (11.9) | 0.15 |
| LVEF (%) | 59.5 (9.1) | 57.4 (10.4) | 65.7 (10.7) | 60.6 (8.6) | 0.001 |
| Medication* | |||||
| Beta blocker | 18 (75.0) | 17 (36.2) | 16 (31.4) | 44 (65.7) | < 0.001 |
| Calsium blocker | 10 (41.7) | 12 (26.1) | 9 (17.6) | 15 (22.4) | 0.16 |
| ACE inhibitor/ Angiotensin receptor blocker | 17 (70.8) | 26 (55.3) | 20 (39.2) | 36 (53.7) | 0.070 |
| Acetylsalicylic acid | 18 (75.0) | 20 (42.6) | 15 (29.4) | 47 (70.1) | < 0.001 |
| Adenosine-diphosphate receptor antagonists | 4 (16.7) | 3 (6.4) | 2 (3.9) | 3 (4.5) | 0.16 |
| Warfarin | 1 (4.2) | 3 (6.5) | 4 (7.8) | 5 (7.5) | 1.0 |
| Novel oral anticoagulant | 3 (12.5) | 3 (6.4) | 6 (11.8) | 5 (7.6) | 0.66 |
| Statin | 21 (87.5) | 30 (63.8) | 28 (54.9) | 55 (82.1) | 0.002 |
| Ezetimibe | 7 (29.2) | 3 (6.4) | 4 (7.8) | 8 (12.1) | 0.046 |
| Nitrate | 8 (33.3) | 1 (2.1) | 1 (2.0) | 16 (24.2) | < 0.001 |
The values denote mean (standard deviation) or number (percentage)*
CABG: coronary artery bypass grafting; AVR: aortic valve replacement; MVS: mitral valve surgery; PCI-CA: percutaneous coronary intervention or coronary angiography; BMI: body mass index; HDL: high density lipoprotein; LDL: low density lipoprotein; LVEF: Left ventricular ejection fraction; ACE: angiotensin-converting enzyme
Kruskall–Wallis test was used to analyze group differences for numerical variables and Fisher’s Exact test for categorical variables
Variation in accelerometer measures of physical activity and sedentary behaviour per day in the patient groups
| CABG | AVR | MVS | PCI-CA | ||
|---|---|---|---|---|---|
| Steps (number) | Mean min max SD | 4665 1595 9836 2679 | 6332 812 12,638 3280 | 6099 1761 13,594 2909 | 6094 1444 13,322 2597 |
| MVPA (min) | Mean min max SD | 22 1.5 51 19 | 41* 0.9 165 35 | 35 2.2 112 26 | 37 1.9 95 23 |
| LPA (min) | Mean min max SD | 181 90 387 84 | 198 71 396 81 | 213 75 556 86 | 205 62 411 84 |
| Standing (min) | Mean min max SD | 82 26 153 41 | 72 8.3 178 36 | 76 18 193 45 | 98 28 313 56 |
| SB(min) | Mean min max SD | 636 472 903 112 | 605 310 866 129 | 581 370 767 85 | 566* 355 767 101 |
| 3-minute mean MET level | Mean min max SD | 3.5 2.6 4.5 0.7 | 4.1* 2.7 7.7 1.1 | 4.1* 2.4 7.9 1.1 | 4.0* 2.9 6.5 0.6 |
| 3-minute peak MET level | Mean min max SD | 3.9 2.8 5.2 0.8 | 4.8* 3.0 10.9 1.5 | 4.9* 3.3 8.2 1.3 | 4.7* 3.5 8.5 0.8 |
The values denote mean, minimum, maximum and standard deviation (SD)
CABG: coronary artery bypass grafting; AVR: aortic valve replacement; MVS: mitral valve surgery; PCI-CA: percutaneous coronary intervention or coronary angiography; MVPA: moderate-to-vigorous physical activity; LPA: light physical activity; SB: sedentary behaviour; MET: metabolic equivalent (3.5 mL/kg/min of oxygen consumption)
*Indicates statistically significant (p < 0.05) difference between the patient groups, CABG group as the reference group. The group differences were analyzed with Analysis of Covariance using Sidak-adjustment to correct for multiple comparisons
Fig. 2Average time spent sleeping, and during wake time in physical activity and sedentary behaviour in different patient groups and FinFit2017 population sample. CABG: coronary artery bypass grafting; AVR: aortic valve replacement; MVS: mitral valve surgery; PCI-CA: percutaneous coronary intervention or coronary angiography; FinFit2017: population-based sample of 60-69-year-old Finnish adults.
Fig. 3Mean number of daily steps. The values denote mean and 95% confidence interval. CABG: coronary artery bypass grafting; AVR: aortic valve replacement; MVS: mitral valve surgery; PCI-CA: percutaneous coronary intervention or coronary angiography; FinFit2017: population-based sample of 60-69-year-old Finnish adults. *Indicates statistically significant difference (p < 0.05) between patient groups and FinFit2017 group (Independent samples t-test assuming that variances are not equal)
Fig. 4Total physical activity (A), moderate-to-vigorous physical activity (B) and sedentary behaviour (C) accumulating from different bout lengths (mean hours or minutes per day). CABG: coronary artery bypass grafting; AVR: aortic valve replacement; MVS: mitral valve surgery; PCI-CA: percutaneous coronary intervention or coronary angiography; FinFit2017: population-based sample of 60-69-year-old Finnish adults. *Indicates statistically significant difference (p < 0.05) between the patient groups and the FinFit2017 group (Independent samples t-test assuming that variances are not equal).