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Literature DB >> 3584106

Complete amino acid sequence of staphylococcal enterotoxin A.

I Y Huang, J L Hughes, M S Bergdoll, E J Schantz.

Abstract

The amino acid sequence of staphylococcal enterotoxin A is presented. Staphylococcal enterotoxin A is a single-chain polypeptide which consists of 233 amino acid residues with a molecular weight of 27,078 and has the amino acid composition Cys2, Asp17, Asn19, Thr16, Ser13, Glu15, Gln12, Pro4, Gly15, Ala7, Val13, Met2, Ile10, Leu23, Tyr18, Phe8, His6, Lys24, Arg7, Trp2, with serine as both amino- and carboxyl-terminal amino acids. Automated sequence analysis of intact enterotoxin A, as well as characterization of the peptides obtained from cyanogen bromide treatment and trypsin and chymotrypsin digestion, led to the elucidation of the complete primary structure of this protein. Less structural homology is observed among staphylococcal enterotoxins A, B (Huang, I-Y., and Bergdoll, M. S. (1970) J. Biol. Chem. 245, 3518-3525), and C1 (Schmidt, J. J., and Spero, L. (1983) J. Biol. Chem. 258, 6300-6306) than that seen between enterotoxins B and C1.

Entities: Chemical Mutation

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Year: 1987 PMID： 3584106

Source DB: PubMed Journal: J Biol Chem ISSN： 0021-9258 Impact factor: 5.157

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Cited

11 in total

1. Cell surface molecules involved in early events in T-cell mitogenic stimulation by staphylococcal enterotoxins.

Authors: S M Vroegop; S E Buxser
Journal: Infect Immun Date: 1989-06 Impact factor: 3.441

2. Nucleotide sequence of the type C3 staphylococcal enterotoxin gene suggests that intergenic recombination causes antigenic variation.

Authors: J L Couch; M J Betley
Journal: J Bacteriol Date: 1989-08 Impact factor: 3.490

3. Interleukin-8 (IL-8) is a major neutrophil chemotaxin from human alveolar macrophages stimulated with staphylococcal enterotoxin A (SEA).

Authors: E J Miller; S Nagao; F K Carr; J M Noble; A B Cohen
Journal: Inflamm Res Date: 1996-08 Impact factor: 4.575

4. T-cell epitope analysis using subtracted expression libraries (TEASEL): application to a 38-kDA autoantigen recognized by T cells from an insulin-dependent diabetic patient.

Authors: P I Neophytou; B O Roep; S D Arden; E M Muir; G Duinkerken; A Kallan; R R de Vries; J C Hutton
Journal: Proc Natl Acad Sci U S A Date: 1996-03-05 Impact factor: 11.205

5. Identification of a bacteriophage containing a silent staphylococcal variant enterotoxin gene (sezA+).

Authors: M T Soltis; J J Mekalanos; M J Betley
Journal: Infect Immun Date: 1990-06 Impact factor: 3.441

6. Dual roles for class II major histocompatibility complex molecules in staphylococcal enterotoxin-induced cytokine production and in vivo toxicity.

Authors: D Grossman; J G Lamphear; J A Mollick; M J Betley; R R Rich
Journal: Infect Immun Date: 1992-12 Impact factor: 3.441

Complete amino acid sequence of staphylococcal enterotoxin A.

1. Cell surface molecules involved in early events in T-cell mitogenic stimulation by staphylococcal enterotoxins.

2. Nucleotide sequence of the type C3 staphylococcal enterotoxin gene suggests that intergenic recombination causes antigenic variation.

3. Interleukin-8 (IL-8) is a major neutrophil chemotaxin from human alveolar macrophages stimulated with staphylococcal enterotoxin A (SEA).

4. T-cell epitope analysis using subtracted expression libraries (TEASEL): application to a 38-kDA autoantigen recognized by T cells from an insulin-dependent diabetic patient.

5. Identification of a bacteriophage containing a silent staphylococcal variant enterotoxin gene (sezA+).

6. Dual roles for class II major histocompatibility complex molecules in staphylococcal enterotoxin-induced cytokine production and in vivo toxicity.

7. Rapid purification of staphylococcal enterotoxin B by high-pressure liquid chromatography.

8. Cloning and nucleotide sequence of the type E staphylococcal enterotoxin gene.

9. Solid tumor-targeted infiltrating cytotoxic T lymphocytes retained by a superantigen fusion protein.

10. Dissociation of the stimulatory activities of staphylococcal enterotoxins for T cells and monocytes.