| Literature DB >> 35838967 |
Fatemeh Zahedipour1,2, Paul C Guest3, Muhammed Majeed4, Khalid Al-Rasadi5, Tannaz Jamialahmadi6, Amirhossein Sahebkar7,8,9,10.
Abstract
Statins have pleiotropic effects on inflammatory responses in addition to their lipid-lowering action, which contributes to their favorable effect on cardiovascular disorders. Statins affect adhesion, migration, antigen presentation, and cytokine generation of immune cells. Pre-clinical and clinical studies suggest that statin intervention targeted early in the infection might help COVID-19 patients to reduce the effects of acute respiratory distress syndrome (ARDS), the cytokine storm, and vascular collapse by modulating harmful pathogenic mechanisms. This chapter presents a protocol for measuring blood-based biomarkers predictive of these responses in COVID-19 patients using two specific multiplex immunoassays that target proteins that differ widely in concentration.Entities:
Keywords: C-reactive protein; COVID-19; IL-6; IL-8; Multiplex immunoassay; SARS-CoV-2; Simvastatin; Statins; TNF-α; Von Willebrand factor
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Year: 2022 PMID： 35838967 DOI： 10.1007/978-1-0716-2395-4_20
Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745