Literature DB >> 3583756

A potential copper radiopharmaceutical for imaging the heart and brain: copper-labeled pyruvaldehyde bis(N4-methylthiosemicarbazone).

M A Green.   

Abstract

An investigation of the biodistribution of lipophilic copper-64 (half-life = 12.7 h) compounds has been initiated in order to screen potential tracers that could be used to measure regional cerebral and/or myocardial blood flow when labeled with generator-produced 62Cu. The 64Cu complex of pyruvaldehyde bis(N4-methylthiosemicarbazone), [64Cu]Cu-PTSM, was prepared and found to be lipophlic (octanol/saline partition coefficient, log p = 1.97 +/- 0.03). Biodistribution studies following i.v. injection of [64Cu]Cu-PTSM into rats show tracer uptake by the brain and heart. At 1, 5, and 15 min post-injection 3.3, 3.0 and 2.7% of the injected dose was found in the brain. Corresponding brain to blood ratios (per gram) were 3.2, 3.6 and 4.0 respectively. Heart to blood ratios of 7.6, 7.6 and 7.3 were observed at these same time points.

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Year:  1987        PMID： 3583756     DOI： 10.1016/0883-2897(87)90162-0

Source DB:  PubMed          Journal:  Int J Rad Appl Instrum B        ISSN： 0883-2897


  10 in total

1.  Development of a high performance zinc-62/copper-62 radionuclide generator for positron emission tomography.

Authors:  J Zweit; R Goodall; M Cox; J W Babich; G A Potter; H L Sharma; R J Ott
Journal:  Eur J Nucl Med       Date:  1992

Review 2.  PET imaging of cardiac hypoxia: opportunities and challenges.

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3.  Heterogeneity of regional nitrogen 13-labeled ammonia tracer distribution in the normal human heart: comparison with rubidium 82 and copper 62-labeled PTSM.

Authors:  R S Beanlands; O Muzik; G D Hutchins; E R Wolfe; M Schwaiger
Journal:  J Nucl Cardiol       Date:  1994 May-Jun       Impact factor: 5.952

4.  An impaired mitochondrial electron transport chain increases retention of the hypoxia imaging agent diacetylbis(4-methylthiosemicarbazonato)copperII.

Authors:  Paul S Donnelly; Jeffrey R Liddell; SinChun Lim; Brett M Paterson; Michael A Cater; Maria S Savva; Alexandra I Mot; Janine L James; Ian A Trounce; Anthony R White; Peter J Crouch
Journal:  Proc Natl Acad Sci U S A       Date:  2011-12-15       Impact factor: 11.205

5.  QSAR studies of copper azamacrocycles and thiosemicarbazones: MM3 parameter development and prediction of biological properties.

Authors:  Peter Wolohan; Jeongsoo Yoo; Michael J Welch; David E Reichert
Journal:  J Med Chem       Date:  2005-08-25       Impact factor: 7.446

6.  In vitro and in vivo evaluation of bifunctional bisthiosemicarbazone 64Cu-complexes for the positron emission tomography imaging of hypoxia.

Authors:  Paul D Bonnitcha; Amy L Vāvere; Jason S Lewis; Jonathan R Dilworth
Journal:  J Med Chem       Date:  2008-04-17       Impact factor: 7.446

7.  Clinical application of 62Zn/62Cu positron generator: perfusion and plasma pool images in normal subjects.

Authors:  H Okazawa; Y Fujibayashi; Y Yonekura; N Tamaki; S Nishizawa; Y Magata; K Ishizu; T Tsuchida; N Sadato; J Konishi
Journal:  Ann Nucl Med       Date:  1995-05       Impact factor: 2.668

8.  Evaluation of copper(II)-pyruvaldehyde bis (N-4-methylthiosemicarbazone) for tissue blood flow measurement using a trapped tracer model.

Authors:  H Young; P Carnochan; J Zweit; J Babich; S Cherry; R Ott
Journal:  Eur J Nucl Med       Date:  1994-04

9.  Uncovering Disease Mechanisms in a Novel Mouse Model Expressing Humanized APOEε4 and Trem2*R47H.

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10.  Plcg2M28L Interacts With High Fat/High Sugar Diet to Accelerate Alzheimer's Disease-Relevant Phenotypes in Mice.

Authors:  Adrian L Oblak; Kevin P Kotredes; Ravi S Pandey; Alaina M Reagan; Cynthia Ingraham; Bridget Perkins; Christopher Lloyd; Deborah Baker; Peter B Lin; Disha M Soni; Andy P Tsai; Scott A Persohn; Amanda A Bedwell; Kierra Eldridge; Rachael Speedy; Jill A Meyer; Johnathan S Peters; Lucas L Figueiredo; Michael Sasner; Paul R Territo; Stacey J Sukoff Rizzo; Gregory W Carter; Bruce T Lamb; Gareth R Howell
Journal:  Front Aging Neurosci       Date:  2022-06-24       Impact factor: 5.702
  10 in total

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