OBJECTIVE: This study mainly analyzed the alterations of serum inflammatory cytokines (ICs) and fibrosis makers in patients with essential hypertension (EH) and the risk factors (RFs). METHODS: In this retrospective study, a total of 145 patients with EH admitted from January 2013 to January 2018 were selected as the research subjects, among which 89 patients without left ventricular hypertrophy (LVH) were included in the EH group and 56 patients with LVH were set as the LVH group. In addition, another 50 healthy subjects who underwent physical examination during the same period were selected as the healthy control (HC) group. The alterations of serum ICs such as interleukin (IL)-6, IL-10 and IL-18, and fibrosis makers like type III procollagen (PCIII), fibronectin (LN) and hyaluronic acid (HA) of the three groups were analyzed, and the RFs of LVH in EH patients were analyzed using the multivariate logistic model. RESULTS: Statistically higher levels of IL-6, IL-18, PCIII, LN and HA with lower IL-10 levels were determined in the LVH group compared with the EH group. In comparison with the HC group, IL-6, IL-18, PCIII, LN and HA in the EH group were significantly higher, while IL-10 was significantly lower. On the other hand, BMI, LVMI, IL-6, IL-18, PCIII, LN, and HA were identified by multivariate logistic analysis to be the RFs affecting LVH in EH patients, while IL-10 was its protective factor. CONCLUSIONS: The above results suggest that serum ICs (except IL-10) and fibrosis markers are up-regulated abnormally in EH patients with LVH, and BMI, LVMI, IL-6, IL-10, IL-18, PCIII, LN, and HA are all independent predictors of LVH in EH patients. AJTR
OBJECTIVE: This study mainly analyzed the alterations of serum inflammatory cytokines (ICs) and fibrosis makers in patients with essential hypertension (EH) and the risk factors (RFs). METHODS: In this retrospective study, a total of 145 patients with EH admitted from January 2013 to January 2018 were selected as the research subjects, among which 89 patients without left ventricular hypertrophy (LVH) were included in the EH group and 56 patients with LVH were set as the LVH group. In addition, another 50 healthy subjects who underwent physical examination during the same period were selected as the healthy control (HC) group. The alterations of serum ICs such as interleukin (IL)-6, IL-10 and IL-18, and fibrosis makers like type III procollagen (PCIII), fibronectin (LN) and hyaluronic acid (HA) of the three groups were analyzed, and the RFs of LVH in EH patients were analyzed using the multivariate logistic model. RESULTS: Statistically higher levels of IL-6, IL-18, PCIII, LN and HA with lower IL-10 levels were determined in the LVH group compared with the EH group. In comparison with the HC group, IL-6, IL-18, PCIII, LN and HA in the EH group were significantly higher, while IL-10 was significantly lower. On the other hand, BMI, LVMI, IL-6, IL-18, PCIII, LN, and HA were identified by multivariate logistic analysis to be the RFs affecting LVH in EH patients, while IL-10 was its protective factor. CONCLUSIONS: The above results suggest that serum ICs (except IL-10) and fibrosis markers are up-regulated abnormally in EH patients with LVH, and BMI, LVMI, IL-6, IL-10, IL-18, PCIII, LN, and HA are all independent predictors of LVH in EH patients. AJTR
Authors: Zhen Zhou; Lei Xu; Rui Wang; Akos Varga-Szemes; James A Durden; U Joseph Schoepf; Zhonghua Sun; Zhanming Fan Journal: Int J Cardiol Date: 2019-01-15 Impact factor: 4.164
Authors: Jéssica S G Miguez; Vanessa Dela Justina; Alecsander F M Bressan; Patrícia G F Marchi; Adenilda C Honorio-França; Fernando S Carneiro; R Clinton Webb; Rita C Tostes; Fernanda R Giachini; Victor V Lima Journal: Life Sci Date: 2018-07-31 Impact factor: 5.037