Clinical efficacy and safety of comprehensive nursing intervention in acute leukemia patients with myelosuppression after chemotherapy.

OBJECTIVE: To investigate the clinical efficacy and safety of comprehensive nursing intervention in acute leukemia patients with myelosuppression after chemotherapy.
METHODS: Eighty acute leukemia patients with myelosuppression after chemotherapy admitted to our hospital from April 2018 to December 2021 were selected and divided, according to the nursing mode, as the conventional group (n=40) with routine nursing mode and the comprehensive group (n=40) with the comprehensive nursing mode. Patients' anxiety (Self-Rating Anxiety Scale, SAS) scores, depression (Self-Rating Depression Scale, SDS) scores, occurrence of complications, nursing satisfaction, nursing experience, complaint rate, and Visual Analogue Scale (VAS) score were compared between the two groups so as to analyze the efficacy and safety of comprehensive nursing intervention. The improvement of quality of life in the two groups was observed and analyzed using the short form of quality of life measurement (WHOQOL-BREF). Logistic regression analysis was performed to analyze the risk factors for nosocomial infection in patients with comprehensive nursing intervention.
RESULTS: No statistically significant differences in SAS and SDS scores between the two groups were found prior nursing (P>0.05), while after nursing, scores in the two groups both decreased, with those in the comprehensive group significantly lower than in the conventional group (P<0.05). The incidence of complications after nursing in the comprehensive group was significantly lower than that in the conventional group, and the difference was statistically significant (P<0.05). Nursing satisfaction of patients in the comprehensive group were significantly higher than that in the conventional group (P<0.05). After nursing, the nursing experience of the comprehensive group was significantly better than that of the conventional group (P<0.05); the complaint rate of the comprehensive group was significantly lower than that of the conventional group (P<0.05); before nursing, there was no significant difference in the VAS scores between the two groups of patients (P>0.05); after nursing, the VAS score of the comprehensive group was significantly lower than that of the conventional group (P<0.05). Before nursing, there was no significant difference in WHOQOL-BREF scores between the two groups (P>0.05); after nursing, the comprehensive group was higher than the conventional group. Among the 40 patients in the comprehensive nursing group, 15 patients developed infection. The number of neutrophils, age above 40, white blood cell count, hemoglobin content, high-intensity chemotherapy and glucocorticoid therapy were independent risk factors for nosocomial infection in patients with comprehensive nursing intervention (P<0.05).
CONCLUSION: Comprehensive nursing intervention for patients with myelosuppression after chemotherapy for acute leukemia can effectively improve the patient's nursing experience, reduce the patient's complaint rate, alleviate the patient's physical pain, relieve the patient's anxiety, depression and other negative emotions, and reduce the patient's complications, suggesting that comprehensive nursing intervention exerts better clinical efficacy and has high safety, which merits promotion clinically. AJTR