Aikeremujiang Muheremu1, Junyao Jiang2, Maihemuti Yakufu3, Abudunaibi Aili1, Lei Li1, Zhaohui Luo4. 1. Department of Spine Surgery, Sixth Affiliated Hospital of Xinjiang Medical University Tianshan District, Urumqi 86830001, Xinjiang, China. 2. Class of 1806 Clinical Medicine, School of Basic Medical Sciences, Henan University of Science and Technology Luolong District, Luoyang 86471023, Henan, China. 3. Department of Orthopaedics, Sixth Affiliated Hospital of Xinjiang Medical University Tianshan District, Urumqi 86830001, Xinjiang, China. 4. Department of Nursing, Sixth Affiliated Hospital of Xinjiang Medical University Tianshan District, Urumqi 86830001, Xinjiang, China.
Abstract
OBJECTIVE: To evaluate the susceptibility of pulmonary tuberculosis based on the single nucleotide polymorphism (SNP) of Toll like receptor 4 (TLR4) gene. METHODS: We searched PubMed, Web of science, EMBASE, and Chinese National Knowledge Infrastructure (CNKI) databases using mesh words: "tuberculosis", "pulmonary", "TLR4", "SNP", "Toll like receptor 4", "nucleotide polymorphism" for studies on the relations between TLR4 SNP polymorphism and the risk of pulmonary tuberculosis that were published before September 1st, 2021. Papers were selected according to the inclusion and exclusion criteria established in advance. The allele and genotype data of the four most widely studied SNP loci (rs4986791, rs4986790, rs11536889, rs10759932) in TLR4 gene were extracted and analyzed by Review Manager 5.3 software. RESULTS: 20 studies including a total of 24727 patients were included in the final meta-analysis. Results of the meta-analysis showed that the C allele of rs10759932 increased the risk of pulmonary tuberculosis (odds ratio - OR: 1.144; 95% confidence interval (CI) 1.043-1.254, P = 0.004). Compared with TT genotype, CC+CT genotype of rs10759932 and CT alone genotype significantly increased the risk of pulmonary tuberculosis (OR = 1.218, 95% CI 1.084-1.369, P = 0.001; OR = 1.227, 95% CI 1.085-1.387, P = 0.001). However, rs4986790, rs4986791 and rs11536889 had no significant correlation with the susceptibility of pulmonary tuberculosis (P > 0.05). CONCLUSION: G allele GG+GA genotype, and the GA genotype of rs4986790; C allele, CC+CT genotype, and the CC genotype of rs10759932 increased the risk of pulmonary tuberculosis, and may potentially be used as a marker for pulmonary tuberculosis diagnosis and monitoring. AJTR
OBJECTIVE: To evaluate the susceptibility of pulmonary tuberculosis based on the single nucleotide polymorphism (SNP) of Toll like receptor 4 (TLR4) gene. METHODS: We searched PubMed, Web of science, EMBASE, and Chinese National Knowledge Infrastructure (CNKI) databases using mesh words: "tuberculosis", "pulmonary", "TLR4", "SNP", "Toll like receptor 4", "nucleotide polymorphism" for studies on the relations between TLR4 SNP polymorphism and the risk of pulmonary tuberculosis that were published before September 1st, 2021. Papers were selected according to the inclusion and exclusion criteria established in advance. The allele and genotype data of the four most widely studied SNP loci (rs4986791, rs4986790, rs11536889, rs10759932) in TLR4 gene were extracted and analyzed by Review Manager 5.3 software. RESULTS: 20 studies including a total of 24727 patients were included in the final meta-analysis. Results of the meta-analysis showed that the C allele of rs10759932 increased the risk of pulmonary tuberculosis (odds ratio - OR: 1.144; 95% confidence interval (CI) 1.043-1.254, P = 0.004). Compared with TT genotype, CC+CT genotype of rs10759932 and CT alone genotype significantly increased the risk of pulmonary tuberculosis (OR = 1.218, 95% CI 1.084-1.369, P = 0.001; OR = 1.227, 95% CI 1.085-1.387, P = 0.001). However, rs4986790, rs4986791 and rs11536889 had no significant correlation with the susceptibility of pulmonary tuberculosis (P > 0.05). CONCLUSION: G allele GG+GA genotype, and the GA genotype of rs4986790; C allele, CC+CT genotype, and the CC genotype of rs10759932 increased the risk of pulmonary tuberculosis, and may potentially be used as a marker for pulmonary tuberculosis diagnosis and monitoring. AJTR
Authors: Adrian G Rosas-Taraco; Agnes Revol; Mario C Salinas-Carmona; Adrian Rendon; Guillermo Caballero-Olin; Alma Y Arce-Mendoza Journal: J Infect Dis Date: 2007-10-25 Impact factor: 5.226
Authors: R Olesen; C Wejse; D R Velez; C Bisseye; M Sodemann; P Aaby; P Rabna; A Worwui; H Chapman; M Diatta; R A Adegbola; P C Hill; L Østergaard; S M Williams; G Sirugo Journal: Genes Immun Date: 2007-07-05 Impact factor: 2.676