Literature DB >> 35835524

Predictive value of the New Zealand Early Warning Score for early mortality in low-acuity patients discharged at scene by paramedics: an observational study.

Verity Frances Todd1,2, Melanie Moylan3, Graham Howie4,2, Andy Swain2,5, Aroha Brett4, Tony Smith4, Bridget Dicker4,2.   

Abstract

OBJECTIVES: The utility of New Zealand Early Warning Score (NZEWS) for prediction of adversity in low-acuity patients discharged at scene by paramedics has not been investigated. The objective of this study was to evaluate the association between the NZEWS risk-assessment tool and adverse outcomes of early mortality or ambulance reattendance within 48 hours in low-acuity, prehospital patients not transported by ambulance.
DESIGN: A retrospective cohort study.
SETTING: Prehospital emergency medical service provided by St John New Zealand over a 2-year period (1 July 2016 through 30 June 2018). PARTICIPANTS: 83 171 low-acuity, adult patients who were attended by an ambulance and discharged at scene. Of these, 41 406 had sufficient recorded data to calculate an NZEWS. PRIMARY AND SECONDARY OUTCOMES AND MEASURES: Binary logistic regression modelling was used to investigate the association between the NZEWS and adverse outcomes of reattendance within 48 hours, mortality within 2 days, mortality within 7 days and mortality within 30 days.
RESULTS: An NZEWS greater than 0 was significantly associated with all adverse outcomes studied (p<0.01), compared with the reference group (NZEWS=0). There was a startling correlation between 2-day, 7-day and 30-day mortality and higher early warning scores; the odds of 2-day mortality in patients with an early warning score>10 was 70 times that of those scoring 0 (adjusted OR 70.64, 95% CI: 30.73 to 162.36). The best predictability for adverse outcome was observed for 2-day and 7-day mortality, with moderate area under the receiver operating characteristic curve scores of 0.78 (95% CI: 0.73 to 0.82) and 0.74 (95% CI: 0.71 to 0.77), respectively.
CONCLUSIONS: Adverse outcomes in low-acuity non-transported patients show a significant association with risk prediction by the NZEWS. There was a very high association between large early warning scores and 2-day mortality in this patient group. These findings suggest that NZEWS has significant utility for decision support and improving safety when determining the appropriateness of discharging low-acuity patients at the scene. © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

Entities:  

Keywords:  ACCIDENT & EMERGENCY MEDICINE; EPIDEMIOLOGY; Protocols & guidelines

Mesh:

Year:  2022        PMID: 35835524      PMCID: PMC9289032          DOI: 10.1136/bmjopen-2021-058462

Source DB:  PubMed          Journal:  BMJ Open        ISSN: 2044-6055            Impact factor:   3.006


This is the first investigation of predictive capability of an early warning score (EWS) in a low-acuity patient cohort and reveals its utility in the prehospital environment. The large study cohort (41 406 patients) includes a diverse range of low-acuity clinical presentations. No previous studies have investigated the utility of an EWS to evaluate ambulance reattendance. This is a retrospective study using clinical data that were not collected for the purpose of calculating an EWS; there may be a selection bias as not all vital sign components were mandatory recordings during the study period. We did not capture patients who have self-presented to a medical facility or emergency department.

Introduction

Background

Early warning scores (EWS) are widely used in hospitals as a tool to aid early recognition of deteriorating patients. The EWS assigns numerical values to elements of a patient’s physiological measures such as level of consciousness, blood pressure, heart rate, respiratory rate and oxygen saturation.1 2 The numerical value can either be aggregated as a total score weighted by the severity of derangement of physiological variables or it may be a single extreme parameter to trigger a rapid system response.1 2 Several EWS systems are used, including the National Early Warning Score (NEWS),3 Modified Early Warning Score4 and VitalPAC EWS.5 The New Zealand Early Warning Score (NZEWS) was introduced nationwide in 2017 after the need for a standardised system was highlighted in a study by Psirides et al.6 7 The vital sign (physiological) categories used by the NZEWS are very similar to the United Kingdom’s Royal College of Physicians NEWS,3 which is widely used internationally.8 An updated NEWS (NEWS2) was introduced in 2017 to incorporate peripheral oxygen saturation weighted for the presence of oxygen therapy.9 The NZEWS system is comparable to the NEWS system. Aggregate vital sign scores in the NZEWS are grouped into five colour-coded categories (white 0, yellow 1–5, orange 6–7, red 8–9 and blue≥10), and a single outlying vital sign measurement can trigger grouping into a high-risk red or blue category. The NEWS has been validated in prehospital settings10 11 and has demonstrated utility in the emergency medical service (EMS) acute setting for identifying patients transported to hospital who have an increased risk of hospital admission, intensive care treatment or death.8 12–15 However, there has been little exploration of its use in decision support regarding treatment or transport of patients in low-acuity settings. Low-acuity cases account for the majority (approximately 85%) of the EMS workload in New Zealand. All levels of EMS personnel in New Zealand can autonomously discharge a patient at the scene if immediate medical attention at an emergency department or other medical facility is not indicated. However, these patients who are not transported are a potentially high-risk cohort.16 Implementation of a tool such as the NZEWS that could appropriately assess the risk of deterioration in these patients would assist in safer decision-making regarding discharge of patients at the scene following EMS assessment.

Objectives

The primary aim of this study was to investigate the association between the aggregated total NZEWS and adverse outcomes in low-acuity adult patients discharged at the scene by EMS. The adverse outcomes evaluated in this study are ambulance reattendance within 48 hours, and mortality within 2, 7 and 30 days. The secondary aim of this study was to determine the accuracy of the NZEWS in predicting an adverse outcome in low-acuity, non-transported adult patients.

Methods

Study design

This was a retrospective cohort study of patients who were discharged at the scene by EMS paramedics. Clinical and demographic characteristics were compared between groups of patients categorised by type and severity of adverse outcome. The adverse outcomes investigated were: ambulance reattendance within 48 hours, mortality within 2 days, mortality within 7 days and mortality within 30 days.

Study setting

The patients included in this study are adults attended by St John New Zealand EMS over a 2-year period (1 July 2016 through 30 June 2018). St John is the largest EMS provider in New Zealand, covering 90% of its population of almost 5 million. The Wellington region of New Zealand is serviced by Wellington Free Ambulance. The St John New Zealand EMS has previously been described in detail.17 All paramedic practice levels in New Zealand can autonomously determine whether ambulance transport is required or not and recommend the most appropriate medical facility to which the patient should be transported. EMS personnel can also recommend that the patient takes private transport to a medical facility. Currently in New Zealand, EMS personnel practicing at the level of paramedic and above are registered health professionals. The NZEWS is not currently included in the Clinical Procedures and Guidelines followed by the New Zealand ambulance services.

Participants

The selection of these low-acuity, discharged-at-scene cases has been described in detail previously.17 Briefly, clinical triage status codes are given to a patient by NZEMS personnel. The NZEMS status codes are: 0—dead, 1—immediate threat to life, 2—potential threat to life, 3—unlikely threat to life, 4—no threat to life. For this study, patients with a final status code of 3 or 4 were deemed low-acuity and appropriate for non-transport. Inclusion criteria included: adults (15 years or older), National Health Index (NHI) identifier recorded, low acuity (final status 3 or 4) and discharged at scene by an attending paramedic. Exclusion criteria included: no recorded NHI number, documented evidence of ambulance transport, under palliative care, high acuity (final status 1 or 2), death prior to ambulance personnel leaving the scene (status 0) and frequent users of the ambulance service (≥3 ambulance attendances within a month or ≥12 ambulance visits in a 2-year period) (see figure 1).
Figure 1

Inclusion and exclusion criteria for the cases included in the New Zealand Early Warning Score (NZEWS) analysis. EMS, emergency medical service.

Inclusion and exclusion criteria for the cases included in the New Zealand Early Warning Score (NZEWS) analysis. EMS, emergency medical service.

Patient and public involvement

Patients or the public were not involved in the design, or conduct, or reporting, or dissemination plans of our research.

Variables

This study was conducted using St John New Zealand electronic patient report form (ePRF) data, collected for the purposes of clinical audit. The outcome variables of interest were ambulance reattendance within 48 hours of the index event, 2-day, 7-day and 30-day mortality. Ambulance reattendance was identified by encrypted NHI matching within the ePRF dataset. Data were only included for the first ambulance attendance for those patients who had an ambulance reattend within 48 hours, and subsequent reattendance within the 48 hours was noted as an adverse outcome. Only the first ambulance attendance for each patient within the 2-year study period was included in the analysis. The data variables identified included respiration rate, oxygen saturation, use of supplemental oxygen, temperature, systolic blood pressure, heart rate and level of consciousness (alert, voice, pain, unresponsive), and these were used to retrospectively calculate the NZEWS.7 Only patients with a complete set of all seven vital signs required for the calculation of an NZEWS were included in the analysis. In the case where multiple vital sign measures were recorded, only the last recorded measurement was included in the NZEWS calculation. The total aggregate NZEWS are grouped into five deterioration risk groups (from low risk to high risk): white (NZEWS=0), yellow (NZEWS 1–5), orange (NZEWS 6–7), red (NZEWS 8–9 or any vital sign in red zone) and blue (NZEWS≥10 or any vital sign in blue zone) (figure 2).
Figure 2

The distribution of prehospital New Zealand Early Warning Score (NZEWS) values and NZEWS colour groupings in low-acuity adult patients discharged at scene. The number of patients with each total NZEWS is shown. Patients with an NZEWS>16 were consolidated. Most patients presented with low NZEWS and grouped within the white and yellow risk groups.

The distribution of prehospital New Zealand Early Warning Score (NZEWS) values and NZEWS colour groupings in low-acuity adult patients discharged at scene. The number of patients with each total NZEWS is shown. Patients with an NZEWS>16 were consolidated. Most patients presented with low NZEWS and grouped within the white and yellow risk groups. Demographic variables collected from ePRF have been extensively described previously.17 The date of death was provided by the Ministry of Health, New Zealand, matched by patient NHI.

Statistical methods

Logistic regression was used to investigate outcome differences, with data presented as adjusted OR (AOR) with 95% CI. For the unadjusted logistic regression, bivariate associations were examined between the dependent and each independent variable. For multivariate logistic regression, the variables age, sex, ethnicity, deprivation and NZEWS were included in a forward conditional model. Data analysis was performed using IBM SPSS (V.28.0)18 and RStudio (V1.3.1 073).19 A p value<0.05 was considered statistically significant. The area under the receiver operating characteristic curve (AUROC) was calculated to evaluate predictive ability of the total aggregate NZEWS with each adverse outcome, along with its 95% CI. We computed sensitivity and specificity for each outcome using a cut-off value that generated the greatest Youden’s index.20 An unmodified, non-weighted Youden’s index was calculated in SPSS (V.28.0) by determining the maximal value of sensitivity+specificity – 1.

Results

Following application of the exclusion criteria, 83 171 low-acuity, adult patients were discharged at scene during this 2-year period, with 71 580 first ambulance attendance events. Of these, 41 406 (58%) had sufficient data to calculate an NZEWS (figure 1). The characteristics of the NZEWS calculable subset were similar to the low-acuity, non-transported subset without calculable NZEWS (table 1).
Table 1

Characteristics of low-acuity discharged-at-scene adult patients with and without sufficient information to calculate a New Zealand Early Warning Score

VariableVariable categoryAll discharged-at-scene adultsDischarged-at-scene adults without a calculable EWS (<7 vital signs recorded)Discharged-at-scene adults with calculable EWS (7 vital signs recorded)
71 58030 174 (42.2%)41 406 (57.8%)
Age, mean±SD57.57±24.5454.84±24.9759.55±24.03
SexMale31 356 (43.8%)13 668 (45.3%)17 688 (42.7%)
Female40 178 (56.2%)16 481 (54.7%)23 697 (57.3%)
EthnicityEuropean/other52 339 (73.1%)21 887 (72.6%)30 452 (73.6%)
Māori11 186 (15.6%)5090 (16.9%)6096 (14.7%)
Pacific peoples4451 (6.2%)1661 (5.5%)2790 (6.7%)
Asian3584 (5.0%)1530 (5.1%)2054 (5.0%)
DeprivationQuintile 1 (least deprived)9470 (13.6%)3879 (13.3%)5591 (13.9%)
Quintile 210 603 (15.3%)4452 (15.2%)6151 (15.3%)
Quintile 312 837 (18.5%)5351 (18.3%)7486 (18.6%)
Quintile 416 222 (23.4%)6900 (23.6%)9322 (23.2%)
Quintile 5 (most deprived)20 287 (29.2%)8622 (29.5%)11 665 (29.0%)
Urban versus ruralRural16 438 (23.4%)6436 (21.9%)10 002 (24.5%)
Urban53 771 (76.6%)23 011 (78.1%)30 760 (75.5%)
Adverse outcome48-hour ambulance reattendance3764 (5.3%)1460 (4.8%)2304 (5.6%)
2-day mortality180 (0.3%)69 (0.2%)111 (0.3%)
7-day mortality413 (0.6%)158 (0.5%)255 (0.6%)
30-day mortality1214 (1.7%)444 (1.5%)770 (1.9%)
Respiration rate, median, IQR16, 16–1816, 16–1816, 16–18
Oxygen saturation, median, IQR (%)98, 97–9998, 97–9998, 97–99
Use of supplemental oxygen (%)No71 092 (99.3%)30 086 (99.7%)41 006 (99.0%)
Yes488 (0.7%)88 (0.3%)400 (1.0%)
Temperature, median, IQR36.6, 36.2–37.036.6, 36.1–37.036.6, 36.2–37.0
Systolic blood pressure, median, IQR137, 122–150138, 122–150136, 122–150
Heart rate, median, IQR80, 70–9080, 70–8980, 70–90
Level of Consciousness (AVPU)Alert70 470 (98.4%)29 672 (98.3%)40 798 (98.5%)
Not Alert1110 (1.6%)502 (1.7%)608 (1.5%)

Missing values did not exceed 5% for any variable.

AVPU, alert, voice, pain, unresponsive; early warning score, EWS.

Characteristics of low-acuity discharged-at-scene adult patients with and without sufficient information to calculate a New Zealand Early Warning Score Missing values did not exceed 5% for any variable. AVPU, alert, voice, pain, unresponsive; early warning score, EWS. Overall, 5.6% of the cohort (2304 cases) had an ambulance reattendance within 48 hours (table 2). The mortality rate within the NZEWS calculable, non-transported cohort was 0.3% (111 cases) for 2-day mortality, 0.6% (255 cases) for 7-day mortality and 1.9% (770 cases) for 30-day mortality (table 2).
Table 2

Descriptive analysis and associations between New Zealand Early Warning Score (NZEWS) and adverse outcomes in low-acuity patients not transported by ambulance

NZEWS coloursTotal48-hour ambulance reattendance2-day mortality7-day mortality30-day mortalityAdjusted ORs
48-hour ambulance reattendance2-day mortality7-day mortality30-day mortality
(NZEWS total)n (%)n (%)n (%)n (%)n (%)AOR (95% CI)AOR (95% CI)AOR (95% CI)AOR (95% CI)
White (0) (ref)20 438 (49.4)1011 (4.9)11 (0.1)38 (0.2)178 (0.9)1.00*1.00*1.00*1.00*
Yellow (1–5)18 615 (45.0)1089 (5.9)55 (0.3)126 (0.7)403 (2.2)1.23 (1.12 to 1.34)5.62 (2.94 to 10.75)3.89 (2.70 to 5.62)2.60 (2.17 to 3.11)
Orange (6–7)59 (0.1)5 (8.5)0 (0)1 (1.7)4 (6.8)1.64 (0.65 to 4.15)8.24 (1.10 to 61.55)7.37 (2.60 to 20.87)
Red (8–9 or any vital sign in red zone)1956 (4.7)171 (8.7)33 (1.7)69 (3.5)155 (7.9)1.76 (1.48 to 2.09)28.57 (14.36 to 56.81)18.55 (12.36 to 27.83)9.28 (7.39 to 11.65)
Blue (10+ or any vital sign in blue zone)338 (0.8)28 (8.3)12 (3.6)21 (6.2)30 (8.9)1.79 (1.20 to 2.68)70.64 (30.73 to 162.36)38.45 (22.04 to 67.09)12.27 (8.09 to 18.30)
Total 41 406 (100) 2304 (5.6) 111 (0.3) 255 (0.6) 770 (1.9)

Adjusted for age, sex, ethnicity, deprivation and NZEWS; ref—reference group. All columns were significant with respect to the reference group.

*P value<0.001.

AOR, adjusted OR.

Descriptive analysis and associations between New Zealand Early Warning Score (NZEWS) and adverse outcomes in low-acuity patients not transported by ambulance Adjusted for age, sex, ethnicity, deprivation and NZEWS; ref—reference group. All columns were significant with respect to the reference group. *P value<0.001. AOR, adjusted OR. Most of the cohort (94.4%) were in the low risk of deterioration groups with an NZEWS of ≤5 (white, n=20 438 and yellow, n=18 615) (table 2, figure 2). In total, 5.5% of the cohort were in the high-risk of deterioration groups (red, n=1956 and blue, n=338). The smallest NZEWS group was orange (n=59), as 314 patients within this cohort were upgraded by having a single vital sign measurement within the red or blue thresholds (table 1, figure 2). As a result of this small cohort size, there were very few cases in the orange NZEWS group with an adverse outcome, and no orange cases in the 2-day mortality cohort (table 2). The distribution of patients with adverse outcomes by NZEWS colour grouping is shown in table 2.

Primary clinical impressions in low-acuity patients with red and blue NZEWS scores

The most common primary clinical impression for patients with a red or blue NZEWS was ‘respiratory’ (23% and 25% of patients, respectively; online supplemental figures 1 and 2).

Ambulance reattendance within 48 hours

All NZEWS colour groups, with the exception of orange, were significantly more likely to have an ambulance reattend within 48 hours than the white NZEWS group (p<0.001, table 2). There was no clear relationship between the risk of patient deterioration based on NZEWS grouping and 48-hour reattendance, with the greatest odds of ambulance reattendance in the Blue NZEWS group (AOR 1.79, 95% CI: 1.20 to 2.68).

Mortality within 2 days of ambulance attendance

All NZEWS colour categories, with the exception of orange, were associated with an increased odds of 2-day mortality after ambulance attendance compared with the white NZEWS group (p<0.001) (table 2). The 2-day mortality and NZEWS grouping odds increased with increasing acuity. The AOR in the yellow group of 5.62 (95% CI: 2.94 to 10.75) increased to 70.64 (95% CI: 30.73 to 162.36) in the blue group—a 14 times increased odds of 2-day mortality.

Mortality within 7 days of ambulance attendance

The NZEWS colour categories also showed increased odds of 7-day mortality with increasing acuity (table 2). The yellow group had an AOR of 3.89 (95% CI: 2.70 to 5.62), while the blue group had an AOR of 38.45 (95% CI: 22.04 to 67.09) (table 2).

Mortality within 30 days of ambulance attendance

There was a significant association between NZEWS colour grouping and 30-day mortality, with all groups showing increased odds of mortality compared with the white group (p<0.001) (table 2). The greatest odds of 30-day mortality was observed for the blue group (AOR 12.27, 95% CI: 8.09 to 18.60).

Predictability of the NZEWS for adverse outcome in low-acuity, non-transported patients

The AUROC was used to evaluate the predictability of the NZEWS colour groupings for each of the adverse outcomes (table 3). The best predictability for adverse outcome in this study was observed for 2-day mortality, with an AUROC of 0.82 (95% CI: 0.78 to 0.86), yielding a sensitivity of 0.76 and a specificity of 0.78 when using a cut-off value of 1.50 (NZEWS≥2) corresponding to the greatest Youden’s index of 0.54. This was followed by 7-day mortality, with an AUROC of 0.78 (95% CI: 0.75 to 0.81), yielding a sensitivity of 0.68 and a specificity of 0.78 when using a cut-off value of 1.50 (NZEWS≥2) corresponding to the greatest Youden’s index of 0.46. The AUROC score for 30-day mortality was 0.70 (95% CI: 0.68 to 0.73), yielding a sensitivity of 0.55 and specificity of 0.79 when using a cut-off value of 1.50 (NZEWS≥2) corresponding to the greatest Youden’s index of 0.34. The NZEWS appears to have the most utility for predicting early mortality at 2 days, with its utility to predict mortality decreasing over time from the index ambulance attendance.
Table 3

Area under the receiving operating curve (AUROC), cut-off values, sensitivity, specificity and Youden’s Index for each adverse outcome for the aggregate New Zealand Early Warning Score (NZEWS)

Adverse outcomeAUROC result(95% CI)Cut-off valueSensitivitySpecificityYouden’s Index
48-hour reattendance0.55 (0.53 to 0.56)1.50 (NZEWS≥2)0.290.780.07
2-day mortality0.82 (0.78 to 0.86)1.50 (NZEWS≥2)0.760.780.54
7-day mortality0.78 (0.75 to 0.81)1.50 (NZEWS≥2)0.680.780.46
30-day mortality0.70 (0.68 to 0.73)1.50 (NZEWS≥2)0.550.790.34
Area under the receiving operating curve (AUROC), cut-off values, sensitivity, specificity and Youden’s Index for each adverse outcome for the aggregate New Zealand Early Warning Score (NZEWS) The AUROC score for 48-hour ambulance reattendance of 0.55 (95% CI: 0.53 to 0.56) revealed that NZEWS has no discriminatory ability for reattendance, yielding a sensitivity of 0.29 and a specificity of 0.78 when using a cut-off value of 1.50 (NZEWS≥2) corresponding to the greatest Youden’s index of 0.07.

Discussion

In this large study of low-acuity, non-transported patients, we have investigated the utility of using an EWS system—the NZEWS—to predict the adverse outcomes of ambulance reattendance within 48 hours, and mortality at 2, 7 and 30 days. All NZEWS>0 categories were associated with increased odds of patient mortality. The strongest association was identified with 2-day mortality, where the most at-risk of deterioration (blue) group had over 70 times the odds of dying than those with an NZEWS of 0. The NZEWS showed a degree of accuracy for all mortality outcomes. The predictability scores for mortality at 2 and 7 days post-ambulance attendance indicated that the NZEWS had moderate accuracy in identifying patients at risk of dying, while NZEWS provided lower accuracy in identifying patients at risk of dying within 30 days. Our findings indicate that the NZEWS is not a good predictor of ambulance reattendance within 48 hours. To date, almost all studies evaluating the use of a prehospital EWS have focused on acutely unwell patients. Patients who are not transported to hospital represent a high-risk population for the EMSs. We have previously shown that the vast majority (95%) of patients autonomously discharged at scene by New Zealand ambulance personnel do not require ambulance reattendance within 48 hours of the initial examination.17 The combination of the accuracy of prediction and the regression analysis indicate that the NZEWS has significant utility in identifying patients with an increased risk of mortality, especially within 2 days of the initial attendance. However, the NZEWS may not be quite as useful for identifying patients likely to require a subsequent ambulance attendance. The finding of a better predictive value for NZEWS with earlier mortality (2 days) is also consistent with other studies that have evaluated NEWS2 in both the prehospital and in-hospital settings.13 15 21–24 While death may not have been unexpected in some of these patients, it is important to note that identifiable palliative cases were excluded from this cohort. An EWS system does not replace a thorough clinical evaluation of the patient. Patients with high NZEWS scores who did not merit transport to hospital included cases of simple hyperventilation, rapidly responding hypoglycaemic episodes in diabetic patients, and self-limiting seizures in diagnosed epileptics. The NZEWS provides an additional signal of the risk of patient deterioration to the evaluating clinician. Integration of the NZEWS into the electronic platforms currently used to record patient assessment and clinical information would provide a quick tool for assessing risk of deterioration. If all patients with an NZEWS>5 were classified as high-risk and mandated for transport in NZEMS guidelines, 5.7% of the cohort in this study would have been transported to a medical facility. Given that around 20% of all the ~461 000 patients that St John New Zealand attends are not transported,17 applying this theoretical mandate for transport based on the NZEWS score would have resulted in around 5250 more ambulance transports to an emergency department or other medical facility each year—approximately 14 more patients per day. The introduction of the NZEWS to improve patient safety in discharged at scene cases should be considered, as it is unlikely that these ~14 patients per day nationally would overburden emergency departments. Any implementation of NZEWS in the prehospital setting should be accompanied by a study, pre-implementation versus post-implementation, to directly evaluate the impact on patient outcomes. In New Zealand, a competent patient can choose not to be transported to a medical facility for further care, despite an EMS recommendation. A quarter of patients in the red and blue NZEWS groups declined transport. There may be other changes that could improve the predictability of the NZEWS. Currently, the patient’s physiological readings considered as derangement from normal are irrespective of age or ethnicity. It may be that specific factors relating to patient demographics and a more tailored EWS could further improve the utility and accuracy of prediction. Potential for tailoring the EWS to age has been demonstrated in both the prehospital and in-hospital settings, indicating that the addition of age as a parameter to the NEWS has improved prediction of short-term mortality.25 26 Future research into the manipulation of the NZEWS colour categories (eg, altering colour thresholds) may also improve the accuracy for this low-acuity cohort. Tailoring the NZEWS for ethnicity may also be needed. In the New Zealand setting, there are significant health inequities between ethnic groups, particularly affecting New Zealand Māori (indigenous population) and Pacific peoples. For example, life expectancy for Māori is more than 7 years lower than European New Zealanders, thought clinically to be related to increased comorbidities. Māori experience two times the rate of avoidable mortality compared with non-Māori.27 One New Zealand study has suggested that the settings of the NZEWS provide too high a threshold for older people, for those with multimorbidities, and for Māori and Pacific peoples,28 meaning some within these populations are not identified by the NZEWS, perhaps leading to delayed interventions. Evaluation of the relationship between ethnicity and the NZEWS vital sign components in the prehospital environment will be important to ensure equitable and culturally appropriate care. The cultural needs of Māori patients should also be a consideration when a new prehospital pathway is introduced. While introduction of a mandated NZEWS system may be clinically justified, it is important to also consider a holistic view of health which includes physical, mental, spiritual and family health as outlined in the Māori health model—Te Whare Tapa Whā.29 Our study is limited to data that have been collected primarily for the purposes of transfer of patient care and clinical audit. The NZEWS was calculated retrospectively from the last (or only) vital sign measurements recorded. During this study period, the clinical procedures and guidelines used by NZ paramedics did not mandate recording of all vital sign components required to calculate NZEWS in discharged-at-scene patients. This may have resulted in a selection bias in the cohort, as patients without a full set of vital signs were excluded from this study. The outcomes in this study were limited to ambulance reattendance within 48 hours and mortality at 2, 7 and 30 days post attendance. Discharged-at-scene patients who self-presented at a medical facility or hospital emergency department were not captured in this study. We have not optimised the cut-off values of the NZEWS, as we wanted to address the utility of implementing the current NZEWS system in a prehospital context. Further research into optimising the NZEWS for the prehospital setting by including factors such as age and ethnicity is warranted and is the focus of further research.

Conclusions

Adverse outcomes in low-acuity, non-transported patients show a significant association with risk prediction by the NZEWS. The very high association between high-risk EWS and 2-day mortality suggests that this has significant utility in the setting of decision support when determining the appropriateness of discharging low-acuity patients at the scene.
  22 in total

1.  Estimation of the Youden Index and its associated cutoff point.

Authors:  Ronen Fluss; David Faraggi; Benjamin Reiser
Journal:  Biom J       Date:  2005-08       Impact factor: 2.207

Review 2.  Review and performance evaluation of aggregate weighted 'track and trigger' systems.

Authors:  Gary B Smith; David R Prytherch; Paul E Schmidt; Peter I Featherstone
Journal:  Resuscitation       Date:  2008-02-04       Impact factor: 5.262

3.  Can the prehospital National Early Warning Score 2 identify patients at risk of in-hospital early mortality? A prospective, multicenter cohort study.

Authors:  Francisco Martín-Rodríguez; Raúl López-Izquierdo; Carlos Del Pozo Vegas; Irene Sánchez-Soberón; Juan F Delgado-Benito; José Luis Martín-Conty; Miguel A Castro-Villamor
Journal:  Heart Lung       Date:  2020-03-11       Impact factor: 2.210

4.  Factors Associated with Emergency Medical Service Reattendance in Low Acuity Patients Not Transported by Ambulance.

Authors:  Verity F Todd; Andy Swain; Graham Howie; Bronwyn Tunnage; Tony Smith; Bridget Dicker
Journal:  Prehosp Emerg Care       Date:  2021-01-25       Impact factor: 3.077

5.  A review of rapid response team activation parameters in New Zealand hospitals.

Authors:  Alex Psirides; Jennifer Hill; Sally Hurford
Journal:  Resuscitation       Date:  2013-01-29       Impact factor: 5.262

6.  Accuracy of National Early Warning Score 2 (NEWS2) in Prehospital Triage on In-Hospital Early Mortality: A Multi-Center Observational Prospective Cohort Study.

Authors:  Francisco Martín-Rodríguez; Raúl López-Izquierdo; Carlos Del Pozo Vegas; Juan F Delgado Benito; Virginia Carbajosa Rodríguez; María N Diego Rasilla; José Luis Martín Conty; Agustín Mayo Iscar; Santiago Otero de la Torre; Violante Méndez Martín; Miguel A Castro Villamor
Journal:  Prehosp Disaster Med       Date:  2019-10-25       Impact factor: 2.040

7.  Ability of prehospital NEWS to predict 1-day and 7-day mortality is reduced in older adult patients.

Authors:  Jussi Pirneskoski; Mitja Lääperi; Markku Kuisma; Klaus T Olkkola; Jouni Nurmi
Journal:  Emerg Med J       Date:  2021-05-11       Impact factor: 2.740

8.  New Early Warning Score: EMS Off-Label Use in Out-of-Hospital Patients.

Authors:  Federico Semeraro; Giovanni Corona; Tommaso Scquizzato; Lorenzo Gamberini; Anna Valentini; Marco Tartaglione; Andrea Scapigliati; Giuseppe Ristagno; Carmela Martella; Carlo Descovich; Cosimo Picoco; Giovanni Gordini
Journal:  J Clin Med       Date:  2021-06-14       Impact factor: 4.241

9.  Pre-hospital National Early Warning Score (NEWS) is associated with in-hospital mortality and critical care unit admission: A cohort study.

Authors:  Tom E F Abbott; Nicholas Cron; Nidhi Vaid; Dorothy Ip; Hew D T Torrance; Julian Emmanuel
Journal:  Ann Med Surg (Lond)       Date:  2018-01-31

10.  A comparison of the ability of the National Early Warning Score and the National Early Warning Score 2 to identify patients at risk of in-hospital mortality: A multi-centre database study.

Authors:  Marco A F Pimentel; Oliver C Redfern; Stephen Gerry; Gary S Collins; James Malycha; David Prytherch; Paul E Schmidt; Gary B Smith; Peter J Watkinson
Journal:  Resuscitation       Date:  2018-10-01       Impact factor: 5.262

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