Literature DB >> 358297

Actions of prostacyclin (PGI2) and its product, 6-oxo-PGF1alpha on the rat gastric mucosa in vivo and in vitro.

B J Whittle, N K Boughton-Smith, S Moncada, J R Vane.   

Abstract

The effects of prostacyclin (PGI2) and its breakdown product 6-oxo-PGF1alpha on various aspects of gastric function were investigated in the rat. PGI2 increased mucosal blood flow when infused intravenously. PGI2 was a more potent inhibitor of gastric acid secretion in vivo than PGE2. Like PGE2, PGI2 inhibited acid secretion from the rat stomach in vitro. PGI2 had comparable activity to PGE2 in inhibiting indomethacin-induced gastric erosions. Thus prostacyclin shares several of the activities of PGE2, and may be involved in the regulation of gastric mucosal function.

Entities:  

Mesh：

Substances：

Year:  1978        PMID： 358297     DOI： 10.1016/0090-6980(78)90038-2

Source DB:  PubMed          Journal:  Prostaglandins        ISSN： 0090-6980


  23 in total

1.  Mode of action of prostacyclin in human gastric mucosa.

Authors:  B Simon; H Kather
Journal:  Dig Dis Sci       Date:  1979-10       Impact factor: 3.199

2.  Some characteristics of the gastric antisecretory actions of prostaglandins in mammalian perfused whole-stomachs in vitro [proceedings].

Authors:  N K Boughton-Smith; B J Whittle
Journal:  Br J Pharmacol       Date:  1979-05       Impact factor: 8.739

Review 3.  Thirteenth Gaddum Memorial Lecture. Neuronal and endothelium-derived mediators in the modulation of the gastric microcirculation: integrity in the balance.

Authors:  B J Whittle
Journal:  Br J Pharmacol       Date:  1993-09       Impact factor: 8.739

4.  Stimulated gastric prostaglandin output, and the effect of inhibition of prostaglandin synthetase, in the conscious cat.

Authors:  R Baker; B M Jaffe; B Shaw; C W Venables
Journal:  J Physiol       Date:  1981-08       Impact factor: 5.182

5.  Prostacyclin content of gastric and duodenal biopsies.

Authors:  I Rózsa; J Banai; K Tihanyi; I Rákóczi; M Kun
Journal:  Gastroenterol Jpn       Date:  1982

6.  Aspirin-induced gastric ulcers in cats. Prevention by prostacyclin.

Authors:  S J Konturek; T Radecki; T Brzozowski; I Piastucki; A Zmuda; A Dembińska-Kieć
Journal:  Dig Dis Sci       Date:  1981-11       Impact factor: 3.199

7.  Phospholipase inhibition and prostacyclin generation by gastric muscularis and mucosa layers.

Authors:  G Cirino; L Sorrentino
Journal:  Agents Actions       Date:  1986-08

8.  Effects of arachidonic acid on rat gastric acid secretion in response to different secretogogues; inhibition of these effects by indomethacin.

Authors:  M H Frame; I H Main
Journal:  Br J Pharmacol       Date:  1980-06       Impact factor: 8.739

9.  The effect of cigarette smoke on gastroduodenal mucosal endogenous prostacyclin level (experimental and clinical observations).

Authors:  G A Balint; V Varró
Journal:  Agents Actions       Date:  1986-11

10.  Diflunisal protects human gastric mucosa against damage by indomethacin.

Authors:  M M Cohen
Journal:  Dig Dis Sci       Date:  1983-12       Impact factor: 3.199
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.