Literature DB >> 3582904

Cocaine-induced hepatotoxicity in humans.

L E Perino, G H Warren, J S Levine.   

Abstract

A patient with hepatonecrosis associated with cocaine use is presented. Postmortem examination of the liver showed marked periportal inflammation and necrosis, and mild diffuse fatty infiltration. These pathologic findings are identical to those previously reported in a mouse model of cocaine hepatotoxicity.

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Year:  1987        PMID： 3582904     DOI： 10.1016/0016-5085(87)90331-3

Source DB:  PubMed          Journal:  Gastroenterology        ISSN： 0016-5085            Impact factor:   22.682


  14 in total

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2.  Effects of anti-cocaine vaccine and viral gene transfer of cocaine hydrolase in mice on cocaine toxicity including motor strength and liver damage.

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3.  Mitochondrial involvement in cocaine-treated rat hepatocytes: effect of N-acetylcysteine and deferoxamine.

Authors:  A Zaragoza; C Díez-Fernández; A M Alvarez; D Andrés; M Cascales
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4.  Vascular hepatotoxicity related to heroin addiction.

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5.  Substance use disorder is associated with alcohol-associated liver disease in patients with alcohol use disorder.

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6.  Characterization of differential cocaine metabolism in mouse and rat through metabolomics-guided metabolite profiling.

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Review 7.  Biomechanisms of cocaine-induced hepatocyte injury mediated by the formation of reactive metabolites.

Authors:  U A Boelsterli; C Göldlin
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8.  Cocaine hepatotoxicity: a study on the pathogenesis of periportal necrosis.

Authors:  C J Powell; S J Charles; J Mullervy
Journal:  Int J Exp Pathol       Date:  1994-12       Impact factor: 1.925

9.  Systemic Safety of a Recombinant AAV8 Vector for Human Cocaine Hydrolase Gene Therapy: A Good Laboratory Practice Preclinical Study in Mice.

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Review 10.  Glutamate homeostasis and dopamine signaling: Implications for psychostimulant addiction behavior.

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