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Literature DB >> 35819261

Pharmacologic Targeting of TFIIH Suppresses KRAS-Mutant Pancreatic Ductal Adenocarcinoma and Synergizes with TRAIL.

Russell Moser¹, James Annis², Olga Nikolova³, Cliff Whatcott⁴, Kay Gurley¹, Eduardo Mendez⁵, Kim Moran-Jones⁶, Craig Dorrell⁷, Rosalie C Sears⁷, Calvin Kuo⁸, Haiyong Han⁴, Andrew Biankin⁴, Carla Grandori⁹, Daniel D Von Hoff⁴, Christopher J Kemp¹.

Abstract

SIGNIFICANCE: This study utilizes functional genetic and pharmacological profiling of KRAS-mutant pancreatic adenocarcinoma to identify therapeutic strategies and finds that TFIIH inhibition synergizes with TRAIL to induce apoptosis in KRAS-driven pancreatic cancer. ©2022 American Association for Cancer Research.

Entities: Chemical

Mesh：

Substances：

Year: 2022 PMID： 35819261 PMCID： PMC9481717 DOI： 10.1158/0008-5472.CAN-21-4222

Source DB: PubMed Journal: Cancer Res ISSN： 0008-5472 Impact factor: 13.312

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