Khalid Al Sulaiman1,2,3,4, Nouf Al Qahtani1, Mashael Al Muqrin1, Maram Al Dossari1, Ali Al Wabel5, Tareq Al Sulaiman6, Ramesh Vishwakarma7, Abdulaziz Alolayan8, Fatimah Abudayah9, Ghazwa B Korayem10, Ohoud Aljuhani11. 1. Department of Pharmaceutical Care, King Abdulaziz Medical City, Riyadh, Saudi Arabia. 2. King Abdullah International Medical Research Centre/King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia. 3. College of Pharmacy, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia. 4. Saudi Critical Care Pharmacy Research (SCAPE) Platform, Riyadh, Saudi Arabia. 5. Unaizah College of Pharmacy, Qassim University, Qassim, Saudi Arabia. 6. Department of Orthopaedic Surgery, Imam Abdulrahman Alfaisal Hospital, Riyadh, Saudi Arabia. 7. Department of Statistics, European Organization for Research and Treatment of Cancer (EORTC) Headquarters, Brussels, Belgium. 8. College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia. 9. Faculty of Nursing, King Abdulaziz University, Jeddah, Saudi Arabia. 10. Department of Pharmacy Practice, College of Pharmacy, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia. 11. Department of Pharmacy Practice, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
Abstract
OBJECTIVE: To investigate the correlation between the ABO blood group and the risk of recurrent catheter-associated urinary tract infections (CA-UTI) and multi-drug resistant (MDR) organism reinfection in the critically ill. METHODS: This retrospective cohort study enrolled adult patients admitted to the intensive care unit (ICU) with confirmed CA-UTI to investigate the correlation between ABO type and the susceptibility to recurrent, reinfection and MDR reinfection. Patients were classified into two groups based on ABO type (O blood group versus non-O blood group). RESULTS: A total of 81 patients were included in the study: 37 in the O blood group and 44 in the non-O blood group. Patients in the O blood group were associated with significantly lower odds of recurrent CA-UTI (adjusted odds ratio 0.28; 95% confidence interval 0.08, 0.95), a shorter ICU length of stay (LOS) (estimate [SE] -0.24 [0.05]), hospital LOS (estimate [SE] -0.15 [0.03]) and mechanical ventilation duration (estimate [SE] -0.41 [0.07]) compared with the non-O blood group type. CONCLUSION: Non-O blood group type might be a risk factor for recurrent CA-UTI and infection with MDR organism.
OBJECTIVE: To investigate the correlation between the ABO blood group and the risk of recurrent catheter-associated urinary tract infections (CA-UTI) and multi-drug resistant (MDR) organism reinfection in the critically ill. METHODS: This retrospective cohort study enrolled adult patients admitted to the intensive care unit (ICU) with confirmed CA-UTI to investigate the correlation between ABO type and the susceptibility to recurrent, reinfection and MDR reinfection. Patients were classified into two groups based on ABO type (O blood group versus non-O blood group). RESULTS: A total of 81 patients were included in the study: 37 in the O blood group and 44 in the non-O blood group. Patients in the O blood group were associated with significantly lower odds of recurrent CA-UTI (adjusted odds ratio 0.28; 95% confidence interval 0.08, 0.95), a shorter ICU length of stay (LOS) (estimate [SE] -0.24 [0.05]), hospital LOS (estimate [SE] -0.15 [0.03]) and mechanical ventilation duration (estimate [SE] -0.41 [0.07]) compared with the non-O blood group type. CONCLUSION: Non-O blood group type might be a risk factor for recurrent CA-UTI and infection with MDR organism.
Entities:
Keywords:
Critically ill; O-group type; blood group types; catheter-associated urinary tract infections (CA-UTI); intensive care unit (ICU); urinary tract infection (UTI)