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Literature DB >> 3581413

Phase I study of beta-alanyl-melphalan as a potent anticancer drug.

Abstract

The dipeptide beta-alanyl-melphalan was synthesized and tested for its potential anticancer activity. It is shown to possess considerable toxicity toward Ehrlich ascites tumor cells and 3T3 mouse embryo cells in in vitro toxicity assays and is a potent anticancer agent when used in vivo in traditional phase I chemotherapy assays. The potential role for small peptide transport mechanisms in transportation of anticancer agents is discussed.

Entities: Chemical Disease Species

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Year: 1987 PMID： 3581413 DOI： 10.1007/bf00252971

Source DB: PubMed Journal: Cancer Chemother Pharmacol ISSN： 0344-5704 Impact factor: 3.333

16 in total

1. Specificity and regulation of peptide transport on Neurospora crassa.

Authors: L Wolfinbarger; G A Marzluf
Journal: Arch Biochem Biophys Date: 1975-12 Impact factor: 4.013

2. Size restriction on utilization of peptides by amino acid auxotrophs of Neurospora crassa.

Authors: L Wolfinbarger; G A Marzluf
Journal: J Bacteriol Date: 1975-06 Impact factor: 3.490

3. Uptake of peptides by a free-cell neoplasm.

Authors: H N CHRISTENSEN; M L RAFN
Journal: Cancer Res Date: 1952-07 Impact factor: 12.701

4. Investigations on the effect of antitumor peptides and mixtures of same.

Authors: A De Barbieri
Journal: Boll Chim Farm Date: 1972-04

5. Synthesis, acute toxicity and chemotherapeutic anti-cancer activities of a new tripeptidic mustard.

Authors: A De Barbieri; L Dall'Asta; A Comini; V Springolo; P Mosconi; G Coppi
Journal: Farmaco Sci Date: 1983-04

6. Increased cancericidal activity of PTT.119, a new synthetic bis-(2-chloroethyl)amino-L-phenylalanine derivative with carrier amino acids. I. In vitro cytotoxicity.

Authors: M J Yagi; J G Bekesi; M D Daniel; J F Holland; A De Barbieri
Journal: Cancer Chemother Pharmacol Date: 1984 Impact factor: 3.333

7. PTT.119, p-F-Phe-m-bis-(2-chloroethyl)amino-L-Phe-Met ethoxy HCl, a new chemotherapeutic agent active against drug-resistant tumor cell lines.

Authors: M J Yagi; S E Chin; K J Scanlon; J F Holland; J G Bekesi
Journal: Biochem Pharmacol Date: 1985-07-01 Impact factor: 5.858

Phase I study of beta-alanyl-melphalan as a potent anticancer drug.

1. Specificity and regulation of peptide transport on Neurospora crassa.

2. Size restriction on utilization of peptides by amino acid auxotrophs of Neurospora crassa.

3. Uptake of peptides by a free-cell neoplasm.

4. Investigations on the effect of antitumor peptides and mixtures of same.

5. Synthesis, acute toxicity and chemotherapeutic anti-cancer activities of a new tripeptidic mustard.

6. Increased cancericidal activity of PTT.119, a new synthetic bis-(2-chloroethyl)amino-L-phenylalanine derivative with carrier amino acids. I. In vitro cytotoxicity.

7. PTT.119, p-F-Phe-m-bis-(2-chloroethyl)amino-L-Phe-Met ethoxy HCl, a new chemotherapeutic agent active against drug-resistant tumor cell lines.

8. Peptide utilization in yeast. Studies on methionine and lysine auxotrophs of Saccharomyces cerevisiae.

9. Escherichia coli K-12 mutants altered in the transport systems for oligo- and dipeptides.

10. Peptide utilization by amino acid auxotrophs of Neurospora crassa.

1. Pharmacokinetics of peptichemio in myeloma patients: release of m-L-sarcolysin in vivo and in vitro.