Literature DB >> 35804222

A novel mitochondria-targetable NIR fluorescent probe for monitoring intracellular hypobromous acid levels.

Mingshuo Ma1, Yuanyan Liu2, Jie Chen1, Shihua Yu3, Zhigang Liu1, Xiaodan Zeng4.   

Abstract

The development of ultrasensitive in situ detection techniques for monitoring hypobromous acid (HBrO) levels in the biological systems is of great significance to reveal its complex pathological and physiological effects. A simple mitochondria-targetable hydrazine-based near-infrared (NIR) fluorescent probe (Mito-NIR) for detecting HBrO in the mitochondria of live cells is presented in this paper. Probe Mito-NIR displays the ultrafast (< 5 s) response for HBrO. It can detect HBrO with high sensitivity. Additionally, it shows high selectivity towards HBrO over other biologically important substances. Finally, it can monitor the changes of endogenous/exogenous HBrO levels in the mitochondria of live cells. A simple mitochondria-targetable NIR fluorescent probe with picomolar sensitivity for HBrO was developed to specifically track mitochondrial HBrO.
© 2022. The Author(s), under exclusive licence to The Japan Society for Analytical Chemistry.

Entities:  

Keywords:  Fluorescence bioimaging; Fluorescent probe; Hydrazine; Hypobromous acid (HBrO); Mitochondria-targetable; Near-infrared fluorescence emission

Mesh：

Substances：

Year:  2022        PMID： 35804222     DOI： 10.1007/s44211-022-00156-w

Source DB:  PubMed          Journal:  Anal Sci        ISSN： 0910-6340            Impact factor:   1.967


  22 in total

Review 1.  Fluorescent and colorimetric chemosensors for pyrophosphate.

Authors:  Songyi Lee; Karen K Y Yuen; Katrina A Jolliffe; Juyoung Yoon
Journal:  Chem Soc Rev       Date:  2015-01-12       Impact factor: 54.564

Review 2.  Fluorescent chemical probes for accurate tumor diagnosis and targeting therapy.

Authors:  Min Gao; Fabiao Yu; Changjun Lv; Jaebum Choo; Lingxin Chen
Journal:  Chem Soc Rev       Date:  2017-04-18       Impact factor: 54.564

3.  Substrates and products of eosinophil peroxidase.

Authors:  C J van Dalen; A J Kettle
Journal:  Biochem J       Date:  2001-08-15       Impact factor: 3.857

Review 4.  Regulation of cancer cell metabolism.

Authors:  Rob A Cairns; Isaac S Harris; Tak W Mak
Journal:  Nat Rev Cancer       Date:  2011-02       Impact factor: 60.716

5.  Brominating oxidants generated by human eosinophils.

Authors:  S J Weiss; S T Test; C M Eckmann; D Roos; S Regiani
Journal:  Science       Date:  1986-10-10       Impact factor: 47.728

6.  High-Quantum-Yield Mitochondria-Targeting Near-Infrared Fluorescent Probe for Imaging Native Hypobromous Acid in Living Cells and in Vivo.

Authors:  Xiaojun Liu; Aishan Zheng; Dongrui Luan; Xiaoting Wang; Fanpeng Kong; Lili Tong; Kehua Xu; Bo Tang
Journal:  Anal Chem       Date:  2017-01-19       Impact factor: 6.986

7.  A lysosome-targeted probe for the real-time detection of hypobromous acid in living human cancer cells.

Authors:  Yali Wang; Yuan Zhang; Lijun Yang; Huiyuan Wu; Nathaniel Finney
Journal:  Analyst       Date:  2021-04-26       Impact factor: 4.616

Review 8.  Recent progress in the development of fluorescent, luminescent and colorimetric probes for detection of reactive oxygen and nitrogen species.

Authors:  Xiaoqiang Chen; Fang Wang; Ji Young Hyun; Tingwen Wei; Jian Qiang; Xintong Ren; Injae Shin; Juyoung Yoon
Journal:  Chem Soc Rev       Date:  2016-04-19       Impact factor: 54.564

Review 9.  Reaction-based small-molecule fluorescent probes for chemoselective bioimaging.

Authors:  Jefferson Chan; Sheel C Dodani; Christopher J Chang
Journal:  Nat Chem       Date:  2012-12       Impact factor: 24.427

Review 10.  Recent Development of Chemosensors Based on Cyanine Platforms.

Authors:  Wen Sun; Shigang Guo; Chong Hu; Jiangli Fan; Xiaojun Peng
Journal:  Chem Rev       Date:  2016-06-17       Impact factor: 60.622
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.