Literature DB >> 3580381

Arachidonic acid epoxygenase: detection of epoxyeicosatrienoic acids in human urine.

R Toto, A Siddhanta, S Manna, B Pramanik, J R Falck, J Capdevila.   

Abstract

Epoxyeicosatrienoic acids, metabolites of the cytochrome P-450-mediated epoxygenase reaction, were detected in human urine by gas chromatographic-mass spectroscopic techniques after conversion to their hydrogenated and non-hydrogenated methyl and pentafluorobenzyl esters. Initial analysis of the regioisomeric composition utilizing the corresponding hydrogenated pentafluorobenzyl esters revealed the presence of the 8,9- and 14,15-isomers.

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Year:  1987        PMID： 3580381     DOI： 10.1016/0005-2760(87)90199-8

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  6 in total

1.  Endogenous biosynthesis of arachidonic acid epoxides in humans: increased formation in pregnancy-induced hypertension.

Authors:  F Catella; J A Lawson; D J Fitzgerald; G A FitzGerald
Journal:  Proc Natl Acad Sci U S A       Date:  1990-08       Impact factor: 11.205

2.  Two Pools of Epoxyeicosatrienoic Acids in Humans: Alterations in Salt-Sensitive Normotensive Subjects.

Authors:  Fernando Elijovich; Ginger L Milne; Nancy J Brown; Michal Laniado-Schwartzman; Cheryl L Laffer
Journal:  Hypertension       Date:  2017-12-26       Impact factor: 10.190

Review 3.  Bisallylic hydroxylation and epoxidation of polyunsaturated fatty acids by cytochrome P450.

Authors:  E H Oliw; J Bylund; C Herman
Journal:  Lipids       Date:  1996-10       Impact factor: 1.880

4.  Formation of cis-14,15-oxido-5,8,11-icosatrienoic acid from phosphatidylinositol in human platelets.

Authors:  L R Ballou; B K Lam; P Y Wong; W Y Cheung
Journal:  Proc Natl Acad Sci U S A       Date:  1987-10       Impact factor: 11.205

5.  Cytochrome P450 metabolites of arachidonic acid are potent inhibitors of vasopressin action on rabbit cortical collecting duct.

Authors:  D L Hirt; J Capdevila; J R Falck; M D Breyer; H R Jacobson
Journal:  J Clin Invest       Date:  1989-12       Impact factor: 14.808

Review 6.  The renal cytochrome P-450 arachidonic acid system.

Authors:  M Laniado-Schwartzman; N G Abraham
Journal:  Pediatr Nephrol       Date:  1992-09       Impact factor: 3.714
  6 in total

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