Medial prefrontal cortex lesions disrupt prepotent action selection signals in dorsomedial striatum.

The ability to inhibit or adapt unwanted actions or movements is a critical feature of almost all forms of behavior. Many have attributed this ability to frontal brain areas such as the anterior cingulate cortex (ACC) and the medial prefrontal cortex (mPFC), but the exact contribution of each brain region is often debated because their functions are not examined in animals performing the same task. Recently, we have shown that ACC signals a need for cognitive control and is crucial for the adaptation of action selection signals in dorsomedial striatum (DMS) in rats performing a stop-change task. Here, we show that unlike ACC, the prelimbic region of mPFC does not disrupt the inhibition or adaption of an action plan at either the level of behavior or downstream firing in DMS. Instead, lesions to mPFC correlate with changes in DMS signals involved in action initiation and disrupt performance on GO trials while improving performance on STOP trials.