Literature DB >> 3580280

Ultrastructural changes in the parenchymal liver cells of rats treated with high doses of rifampicin.

A Piriou, R Maissiat, A Jacqueson, J M Warnet, J R Claude.   

Abstract

Ultrastructural study of hepatic parenchyma was carried out in female Wistar rats after they had received high doses (400 mg X kg-1) of rifampicin for 1, 2, 4, 6 and 8 days. Morphological changes in the endoplasmic reticulum, Golgi apparatus and mitochondria were observed as early as day 1 of intoxication. These changes corroborate the biochemical data available regarding RFP-induced fatty liver.

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Year:  1987        PMID： 3580280      PMCID： PMC2013009     

Source DB:  PubMed          Journal:  Br J Exp Pathol        ISSN： 0007-1021


  7 in total

1.  [Liver toxicity of combined rifampicin-isoniazid-ethambutol medication (author's transl)].

Authors:  A Austerhoff; U Kindler; P Knop; H J Knieriem
Journal:  Dtsch Med Wochenschr       Date:  1974-05-31       Impact factor: 0.628

2.  [Rifampicin and liver function (72 punctures biopsies)].

Authors:  J Taranger; J P Girbal; G Giacchero
Journal:  Rev Tuberc Pneumol (Paris)       Date:  1970 Jul-Aug

3.  [Effect of isoniazid and rifampicin regimens on the liver of tuberculosis patients].

Authors:  J A Pilheu; M C De Salvo; J A Barcat
Journal:  Medicina (B Aires)       Date:  1979 May-Jun       Impact factor: 0.653

4.  Isolation of a subfraction of rough endoplasmic reticulum closely associated with mitochondria. Evidence for its role in cytochrome P450 synthesis.

Authors:  P J Meier; M A Spycher; U A Meyer
Journal:  Exp Cell Res       Date:  1978-02       Impact factor: 3.905

5.  Enzyme induction with high doses of rifampicin in Wistar rats.

Authors:  A Piriou; A Jacqueson; J M Warnet; J R Claude
Journal:  Toxicol Lett       Date:  1983-07       Impact factor: 4.372

6.  Study of the protective effect of an anabolic steroid, 19-nortestosterone phenylpropionate (19-NTPP) on the fatty liver induced by high doses of rifampicin in the rat.

Authors:  A Piriou; A Jacqueson; M Thévenin; J M Warnet; J R Claude
Journal:  Arch Toxicol Suppl       Date:  1980

7.  The use of lead citrate at high pH as an electron-opaque stain in electron microscopy.

Authors:  E S REYNOLDS
Journal:  J Cell Biol       Date:  1963-04       Impact factor: 10.539
  7 in total
  3 in total

Review 1.  The pregnane X receptor: from bench to bedside.

Authors:  Xiaochao Ma; Jeffrey R Idle; Frank J Gonzalez
Journal:  Expert Opin Drug Metab Toxicol       Date:  2008-07       Impact factor: 4.481

2.  The effects of supra-therapeutic doses of rifampicin on liver function in the perfused rat liver.

Authors:  S M Khedun; B Maharaj; W P Leary
Journal:  Int J Exp Pathol       Date:  1992-08       Impact factor: 1.925

3.  Protective Effects of Vitamin C and NAC on the Toxicity of Rifampin on Hepg2 Cells.

Authors:  Nasser Vahdati-Mashhadian; Mahmoud Reza Jafari; Nasim Sharghi; Toktam Sanati
Journal:  Iran J Pharm Res       Date:  2013       Impact factor: 1.696
  3 in total

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