Literature DB >> 3579947

Pertussis toxin facilitates secretagogue-induced catecholamine release from cultured bovine adrenal chromaffin cells.

T Tanaka, H Yokohama, M Negishi, H Hayashi, S Ito, O Hayaishi.   

Abstract

Pretreatment of cultured bovine adrenal chromaffin cells with pertussis toxin facilitated nicotine-induced catecholamine release. This facilitation was correlated with the ability of the toxin to catalyze the ADP-ribosylation of an approximately 40-kDa membrane protein. The actions of the toxin were reversed by isonicotinamide, an inhibitor of ADP-ribosylation. Catecholamine release due to high K+ and muscarine was also enhanced by pertussis toxin. In all cases, 45Ca2+ uptake was unaltered in cells treated with the toxin. These results suggest that ADP-ribosylation of a 40-kDa membrane protein facilitates catecholamine release from bovine chromaffin cells without affecting 45Ca2+ uptake.

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Year:  1987        PMID： 3579947     DOI： 10.1016/s0006-291x(87)80050-5

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  5 in total

1.  Inhibition of voltage-dependent Ca2+ channels via alpha 2-adrenergic and opioid receptors in cultured bovine adrenal chromaffin cells.

Authors:  T Kleppisch; G Ahnert-Hilger; M Gollasch; K Spicher; J Hescheler; G Schultz; W Rosenthal
Journal:  Pflugers Arch       Date:  1992-06       Impact factor: 3.657

2.  Multiple GTP-binding proteins from cholinergic synaptic vesicles.

Authors:  J K Ngsee; K Miller; B Wendland; R H Scheller
Journal:  J Neurosci       Date:  1990-01       Impact factor: 6.167

3.  Pertussis toxin stimulation of catecholamine release from adrenal medullary chromaffin cells: mechanism may be by direct activation of L-type and G-type calcium channels.

Authors:  V Ceña; K W Brocklehurst; H B Pollard; E Rojas
Journal:  J Membr Biol       Date:  1991-05       Impact factor: 1.843

4.  A pertussis-toxin-sensitive protein controls exocytosis in chromaffin cells at a step distal to the generation of second messengers.

Authors:  J M Sontag; D Thierse; B Rouot; D Aunis; M F Bader
Journal:  Biochem J       Date:  1991-03-01       Impact factor: 3.857

5.  Inhibition of prostaglandin E2-induced phosphoinositide metabolism by phorbol ester in bovine adrenal chromaffin cells.

Authors:  H Yokohama; M Negishi; K Sugama; H Hayashi; S Ito; O Hayaishi
Journal:  Biochem J       Date:  1988-11-01       Impact factor: 3.857
  5 in total

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