Literature DB >> 3579935

The carcinoembryonic antigen (CEA) contains multiple immunoglobulin-like domains.

S Oikawa, S Imajo, T Noguchi, G Kosaki, H Nakazato.   

Abstract

The amino acid sequences of human carcinoembryonic antigen deduced from the cDNA sequences have been analysed. This antigen contains seven extracellular domains (previously recognized three highly repetitive domains are further divided into A and B subdomains each) which are strikingly homologous to each other and to immunoglobulin variable regions, poly-Ig receptor and Thy 1.1. The N-terminal domain lacks immunoglobulin-like fold but the other six domains have, suggesting that the CEA belongs to immunoglobulin superfamily.

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Year:  1987        PMID： 3579935     DOI： 10.1016/s0006-291x(87)80013-x

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  15 in total

Review 1.  New perspectives in lung cancer. 3. The antigens of lung cancer.

Authors:  R L Souhami
Journal:  Thorax       Date:  1992-01       Impact factor: 9.139

2.  Immunoglobulin variable-region-like domains of diverse sequence within the major histocompatibility complex of the chicken.

Authors:  M M Miller; R Goto; S Young; J Chirivella; D Hawke; C G Miyada
Journal:  Proc Natl Acad Sci U S A       Date:  1991-05-15       Impact factor: 11.205

3.  Induction of carcinoembryonic antigen expression in a three-dimensional culture system.

Authors:  J M Jessup; D Brown; W Fitzgerald; R D Ford; A Nachman; T J Goodwin; G Spaulding
Journal:  In Vitro Cell Dev Biol Anim       Date:  1997-05       Impact factor: 2.416

4.  Quantitative considerations supporting the irrelevance of circulating serum CEA for the immunoscintigraphic visualization of CEA expressing carcinomas.

Authors:  K Bosslet; A Steinsträsser; A Schwarz; H P Harthus; G Lüben; L Kuhlmann; H H Sedlacek
Journal:  Eur J Nucl Med       Date:  1988

5.  Intra- and interspecies analyses of the carcinoembryonic antigen (CEA) gene family reveal independent evolution in primates and rodents.

Authors:  F Rudert; W Zimmermann; J A Thompson
Journal:  J Mol Evol       Date:  1989-08       Impact factor: 2.395

6.  MUC18, a marker of tumor progression in human melanoma, shows sequence similarity to the neural cell adhesion molecules of the immunoglobulin superfamily.

Authors:  J M Lehmann; G Riethmüller; J P Johnson
Journal:  Proc Natl Acad Sci U S A       Date:  1989-12       Impact factor: 11.205

7.  Features of the extracellular domain of the S-locus receptor kinase from Brassica.

Authors:  T L Glavin; D R Goring; U Schafer; S J Rothstein
Journal:  Mol Gen Genet       Date:  1994-09-28

8.  Metastatic potential of human colorectal carcinoma SW1222 cells transfected with cDNA encoding carcinoembryonic antigen.

Authors:  J Hashino; Y Fukuda; S Oikawa; H Nakazato; T Nakanishi
Journal:  Clin Exp Metastasis       Date:  1994-07       Impact factor: 5.150

9.  Cloning of the complete gene for carcinoembryonic antigen: analysis of its promoter indicates a region conveying cell type-specific expression.

Authors:  H Schrewe; J Thompson; M Bona; L J Hefta; A Maruya; M Hassauer; J E Shively; S von Kleist; W Zimmermann
Journal:  Mol Cell Biol       Date:  1990-06       Impact factor: 4.272

Review 10.  Carcinoembryonic antigen: function in metastasis by human colorectal carcinoma.

Authors:  J M Jessup; P Thomas
Journal:  Cancer Metastasis Rev       Date:  1989-12       Impact factor: 9.264
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