Literature DB >> 3579928

Presence of tetrahydroisoquinoline and 2-methyl-tetrahydroquinoline in parkinsonian and normal human brains.

T Niwa, N Takeda, N Kaneda, Y Hashizume, T Nagatsu.   

Abstract

1,2,3,4-Tetrahydroisoquinoline (TIQ) and 2-methyl-1,2,3,4-tetrahydroquinoline (2-Me-TQ) were identified for the first time by gas chromatography-mass spectrometry in the parkinsonian and normal human brains. TIQ, an analogue of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), was markedly increased in the parkinsonian brain and could be an endogenous neurotoxin to induce Parkinson's disease.

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Year:  1987        PMID： 3579928     DOI： 10.1016/s0006-291x(87)80075-x

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  16 in total

Review 1.  Animal models of Parkinson's disease: an empirical comparison with the phenomenology of the disease in man.

Authors:  M Gerlach; P Riederer
Journal:  J Neural Transm (Vienna)       Date:  1996       Impact factor: 3.575

Review 2.  Cellular and molecular mechanisms of Parkinson's disease: neurotoxins, causative genes, and inflammatory cytokines.

Authors:  Toshi Nagatsu; Makoto Sawada
Journal:  Cell Mol Neurobiol       Date:  2006-07-06       Impact factor: 5.046

Review 3.  Dietary inhibitors of monoamine oxidase A.

Authors:  Sarah E Dixon Clarke; Rona R Ramsay
Journal:  J Neural Transm (Vienna)       Date:  2010-12-29       Impact factor: 3.575

Review 4.  Bioenergetics and metabolism: a bench to bedside perspective.

Authors:  Russell H Swerdlow
Journal:  J Neurochem       Date:  2016-03-10       Impact factor: 5.372

5.  Cytotoxicity of endogenous isoquinolines to human dopaminergic neuroblastoma SH-SY5Y cells.

Authors:  T Takahashi; W Maruyama; Y Deng; P Dostert; D Nakahara; T Niwa; S Ohta; M Naoi
Journal:  J Neural Transm (Vienna)       Date:  1997       Impact factor: 3.575

6.  Neurotoxicity due to o-quinones: neuromelanin formation and possible mechanisms for o-quinone detoxification.

Authors:  F Solano; V J Hearing; J C García-Borrón
Journal:  Neurotox Res       Date:  2000-02       Impact factor: 3.911

Review 7.  A possible physiological role for cerebral tetrahydroisoquinolines.

Authors:  Jerzy Vetulani; Lucyna Antkiewicz-Michaluk; Irena Nalepa; Mario Sansone
Journal:  Neurotox Res       Date:  2003       Impact factor: 3.911

8.  Inhibition of type A and B monoamine oxidase by 6,7-dihydroxy-1,2,3,4-tetrahydroisoquinolines and their N-methylated derivatives.

Authors:  M Minami; W Maruyama; P Dostert; T Nagatsu; M Naoi
Journal:  J Neural Transm Gen Sect       Date:  1993

9.  Naturally-occurring isoquinolines perturb monamine metabolism in the brain: studied by in vivo microdialysis.

Authors:  W Maruyama; D Nakahara; P Dostert; A Takahashi; M Naoi
Journal:  J Neural Transm Gen Sect       Date:  1993

10.  Uptake of a neurotoxin-candidate, (R)-1,2-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline into human dopaminergic neuroblastoma SH-SY5Y cells by dopamine transport system.

Authors:  T Takahashi; Y Deng; W Maruyama; P Dostert; M Kawai; M Naoi
Journal:  J Neural Transm Gen Sect       Date:  1994
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