Murat A Özer1, İlker F Sarı2, Hakan Koç3, Nurçe Ç Yavuz2, Serkan Özen3, Fazıl Kulaklı2. 1. Department of Ophthalmology, Section of Surgical Sciences, Faculty of Medicine, Giresun University, 28100, Giresun, Debboy, Turkey. dratabeyozer@yandex.com. 2. Department of Physical Treatment and Rehabilitation, Section of Clinical Sciences, Faculty of Medicine, Giresun University, Giresun, Turkey. 3. Department of Ophthalmology, Section of Surgical Sciences, Faculty of Medicine, Giresun University, 28100, Giresun, Debboy, Turkey.
Abstract
PURPOSE: To evaluate the effects of Duloxetine on anterior segment parameters and intraocular pressure (IOP) in open angle eyes. METHODS: 38 eyes of 38 patients with fibromyalgia who had open or wide open angles according to the Shaffer classification. Anterior segment optic coherence tomography was performed before and after (month 3) Duloxetine treatment. IOP, central corneal thickness (CCT), corneal endothelial cell density (CECD) and anterior chamber depth (ACD) were also recorded and evaluated. RESULTS: No statistically significant difference was determined in IOP, CCT and CECD (p > 0.05). However, a statistically significant decrease was determined in both the temporal and nasal anterior chamber angle, angle opening distance, nasal trabecular-iris space area and ACD values between the baseline and month 3 (p < 0.001). DISCUSSION: We think that the short term use of Duloxetine does not lead to clinically significant changes despite their statistically significant effects on the anterior chamber parameters.
PURPOSE: To evaluate the effects of Duloxetine on anterior segment parameters and intraocular pressure (IOP) in open angle eyes. METHODS: 38 eyes of 38 patients with fibromyalgia who had open or wide open angles according to the Shaffer classification. Anterior segment optic coherence tomography was performed before and after (month 3) Duloxetine treatment. IOP, central corneal thickness (CCT), corneal endothelial cell density (CECD) and anterior chamber depth (ACD) were also recorded and evaluated. RESULTS: No statistically significant difference was determined in IOP, CCT and CECD (p > 0.05). However, a statistically significant decrease was determined in both the temporal and nasal anterior chamber angle, angle opening distance, nasal trabecular-iris space area and ACD values between the baseline and month 3 (p < 0.001). DISCUSSION: We think that the short term use of Duloxetine does not lead to clinically significant changes despite their statistically significant effects on the anterior chamber parameters.
Authors: Dallas P Seitz; Robert J Campbell; Chaim M Bell; Sudeep S Gill; Andrea Gruneir; Nathan Herrmann; Alice M Newman; Geoff Anderson; Paula A Rochon Journal: J Clin Psychopharmacol Date: 2012-06 Impact factor: 3.153
Authors: M A Sierra-Rodriguez; F Saenz-Frances; E Santos-Bueso; J Garcia-Feijoo; J C Gonzelez-Romero Journal: Semin Ophthalmol Date: 2013-04-29 Impact factor: 1.975