Literature DB >> 35793242

Persistent SARS-CoV-2 infection with accumulation of mutations in a patient with poorly controlled HIV infection.

Tongai G Maponga1, Montenique Jeffries2, Houriiyah Tegally3, Andrew Sutherland1, Eduan Wilkinson4, Richard J Lessells3, Nokukhanya Msomi5, Gert van Zyl1,6, Tulio de Oliveira3,4,7, Wolfgang Preiser1,6.   

Abstract

A 22-year-old female with uncontrolled advanced HIV infection was persistently infected with SARS-CoV-2 beta variant for 9 months, the virus accumulating >20 additional mutations. Antiretroviral therapy suppressed HIV and cleared SARS-CoV-2 within 6-9 weeks. Increased vigilance is warranted to benefit affected individuals and prevent the emergence of novel SARS-CoV-2 variants.
© The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  COVID-19; SARS-CoV-2; antiretroviral therapy; immunocompromised; infectious virus; mutations; persistent infection; uncontrolled HIV infection

Year:  2022        PMID： 35793242      PMCID： PMC9278209          DOI： 10.1093/cid/ciac548

Source DB:  PubMed          Journal:  Clin Infect Dis        ISSN： 1058-4838            Impact factor:   20.999


  3 in total

1.  Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 Delta Variant Shedding in a Patient With AIDS: Case Report and Review of the Literature.

Authors:  Jillian L Peters; Amary Fall; Steven D Langerman; Margueritta El Asmar; Mari Nakazawa; Aishat Mustapha; Aaron A R Tobian; Heba H Mostafa; Joel N Blankson
Journal:  Open Forum Infect Dis       Date:  2022-09-17       Impact factor: 4.423

2.  Accelerated SARS-CoV-2 intrahost evolution leading to distinct genotypes during chronic infection.

Authors:  Chrispin Chaguza; Anne M Hahn; Mary E Petrone; Shuntai Zhou; David Ferguson; Mallery I Breban; Kien Pham; Mario A Peña-Hernández; Christopher Castaldi; Verity Hill; Wade Schulz; Ronald I Swanstrom; Scott C Roberts; Nathan D Grubaugh
Journal:  medRxiv       Date:  2022-07-02

3.  Methylene blue, Mycophenolic acid, Posaconazole, and Niclosamide inhibit SARS-CoV-2 Omicron variant BA.1 infection of human airway epithelial organoids.

Authors:  Romain Volle; Luca Murer; Anthony Petkidis; Vardan Andriasyan; Alessandro Savi; Cornelia Bircher; Nicole Meili; Lucy Fischer; Daniela Policarpo Sequeira; Daniela Katharina Mark; Alfonso Gomez-Gonzalez; Urs F Greber
Journal:  Curr Res Microb Sci       Date:  2022-07-30
  3 in total

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