Literature DB >> 35793029

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Year:  2022        PMID: 35793029      PMCID: PMC9258693          DOI: 10.1111/jcmm.17446

Source DB:  PubMed          Journal:  J Cell Mol Med        ISSN: 1582-1838            Impact factor:   5.295


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In Xiaonan Zhuang et al. , the picture of ShRNA‐SHP‐1‐rLV + LPS + SP600125 group in Figure 8C is incorrect. The corrected Figure 8 is shown below. The authors confirm that all the results and conclusions of this article remain unchanged.
FIGURE 8

Inflammation induced by LPS was mitigated by the inhibition of the JNK pathway in the retina. (A) Representative immunofluorescent images of the blank‐rLV + PBS, blank‐rLV + LPS and shRNA‐SHP‐1‐rLV + LPS groups at 24 h after LPS administration. (B) Representative images of the blank‐rLV + PBS, blank‐rLV + LPS and SHP‐1‐rLV + LPS groups at 24 h after LPS administration. Red: pJNK; grey: GS; blue: DAPI. Scale bar: 50 μm. (C) Representative biomicroscopic images of the blank‐rLV + PBS, blank‐rLV + LPS, blank‐rLV + LPS + SP600125, shRNA‐SHP‐1‐rLV + LPS, shRNA‐SHP‐1‐rLV + LPS + SP600125 groups at 0, 24, 48 and 72 h after LPS treatment. (D) Clinical scores for the five groups described above. One‐way anova followed by Dunnett's test was used. n = 5 per group. *Blank‐rLV + LPS + SP600125 group versus blank‐rLV + LPS group; #shRNA‐SHP‐1‐rLV + LPS + SP600125 group versus shRNA‐SHP‐1‐rLV + LPS group. (E–H) Western blotting analysis of the retinal expression of COX2, IL‐1β and MIP‐1α at 24 h after LPS administration. One‐way anova followed by Dunnett's test was used. n = 3 per group. */ # p < 0.05 and **/# # p < 0.01

Inflammation induced by LPS was mitigated by the inhibition of the JNK pathway in the retina. (A) Representative immunofluorescent images of the blank‐rLV + PBS, blank‐rLV + LPS and shRNA‐SHP‐1‐rLV + LPS groups at 24 h after LPS administration. (B) Representative images of the blank‐rLV + PBS, blank‐rLV + LPS and SHP‐1‐rLV + LPS groups at 24 h after LPS administration. Red: pJNK; grey: GS; blue: DAPI. Scale bar: 50 μm. (C) Representative biomicroscopic images of the blank‐rLV + PBS, blank‐rLV + LPS, blank‐rLV + LPS + SP600125, shRNA‐SHP‐1‐rLV + LPS, shRNA‐SHP‐1‐rLV + LPS + SP600125 groups at 0, 24, 48 and 72 h after LPS treatment. (D) Clinical scores for the five groups described above. One‐way anova followed by Dunnett's test was used. n = 5 per group. *Blank‐rLV + LPS + SP600125 group versus blank‐rLV + LPS group; #shRNA‐SHP‐1‐rLV + LPS + SP600125 group versus shRNA‐SHP‐1‐rLV + LPS group. (E–H) Western blotting analysis of the retinal expression of COX2, IL‐1β and MIP‐1α at 24 h after LPS administration. One‐way anova followed by Dunnett's test was used. n = 3 per group. */ # p < 0.05 and **/# # p < 0.01
  1 in total

1.  SHP-1 suppresses endotoxin-induced uveitis by inhibiting the TAK1/JNK pathway.

Authors:  Xiaonan Zhuang; Jun Ma; Sisi Xu; Zhongcui Sun; Rong Zhang; Meng Zhang; Gezhi Xu
Journal:  J Cell Mol Med       Date:  2020-11-18       Impact factor: 5.310

  1 in total

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