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Literature DB >> 35791595

A sudden collapse: the disaggregation of amyloid fibres.

Abstract

A hallmark of age-related neurodegenerative diseases is the presence of highly stable protein aggregates, also known as amyloid fibres. As these fibres are strongly associated with disease, it is thought that clearance of these fibres could delay or prevent disease progression. In this issue of The EMBO Journal, Beton et al unravel how the Hsc70/DNAJB1/Apg2 disaggregase machinery disassembles amyloid fibres, using α-synuclein fibrils implicated in Parkinson's Disease as a model substrate.

Entities: Chemical

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Year: 2022 PMID： 35791595 PMCID： PMC9379544 DOI： 10.15252/embj.2022111700

Source DB: PubMed Journal: EMBO J ISSN： 0261-4189 Impact factor: 14.012

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References

7 in total

1. Metazoan Hsp70 machines use Hsp110 to power protein disaggregation.

Authors: Heike Rampelt; Janine Kirstein-Miles; Nadinath B Nillegoda; Kang Chi; Sebastian R Scholz; Richard I Morimoto; Bernd Bukau
Journal: EMBO J Date: 2012-09-18 Impact factor: 11.598

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Authors: Serena Baglioni; Fiorella Casamenti; Monica Bucciantini; Leila M Luheshi; Niccolò Taddei; Fabrizio Chiti; Christopher M Dobson; Massimo Stefani
Journal: J Neurosci Date: 2006-08-02 Impact factor: 6.167

3. All-or-none amyloid disassembly via chaperone-triggered fibril unzipping favors clearance of α-synuclein toxic species.

Authors: Aitor Franco; Pablo Gracia; Adai Colom; José D Camino; José Ángel Fernández-Higuero; Natalia Orozco; Alexander Dulebo; Leonor Saiz; Nunilo Cremades; Jose M G Vilar; Adelina Prado; Arturo Muga
Journal: Proc Natl Acad Sci U S A Date: 2021-09-07 Impact factor: 11.205

A sudden collapse: the disaggregation of amyloid fibres.

1. Metazoan Hsp70 machines use Hsp110 to power protein disaggregation.

2. Prefibrillar amyloid aggregates could be generic toxins in higher organisms.

3. All-or-none amyloid disassembly via chaperone-triggered fibril unzipping favors clearance of α-synuclein toxic species.

4. Human Hsp70 Disaggregase Reverses Parkinson's-Linked α-Synuclein Amyloid Fibrils.

5. Molecular dissection of amyloid disaggregation by human HSP70.

Review 6. Cellular Regulation of Amyloid Formation in Aging and Disease.