Yoshihiro Kakeji1, Takashi Ishikawa2, Satoshi Suzuki3, Kohei Akazawa2, Tomoyuki Irino4, Isao Miyashiro5, Hiroyuki Ono6, Haruhisa Suzuki7, Satoshi Tanabe8, Shigenori Kadowaki9, Kei Muro9, Takeo Fukagawa10, Souya Nunobe11, Takeyuki Wada12, Hitoshi Katai12, Yasuhiro Kodera13. 1. Division of Gastrointestinal Surgery, Department of Surgery, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan. kakeji@med.kobe-u.ac.jp. 2. Department of Medical Informatics, Niigata University Medical and Dental Hospital, Niigata, Japan. 3. Department of Gastroenterological Surgery, Hyogo Cancer Center, Akashi, Hyogo, Japan. 4. Department of Surgery, Keio University School of Medicine, Tokyo, Japan. 5. Cancer Control Center, Osaka International Cancer Institute, Osaka, Japan. 6. Endoscopy Division, Shizuoka Cancer Center, Shizuoka, Japan. 7. Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan. 8. Division of Therapeutic Endoscopy, Kitasato University School of Medicine, Kanagawa, Japan. 9. Department of Clinical Oncology, Aichi Cancer Center Hospital, Nagoya, Japan. 10. Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan. 11. Department of Gastroenterological Surgery, Cancer Institute Ariake Hospital, Tokyo, Japan. 12. Department of Gastric Surgery, National Cancer Center Hospital, Tokyo, Japan. 13. Department of Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Abstract
BACKGROUND: The nationwide registry of the Japanese Gastric Cancer Association collected data of surgically resected cases of gastric cancer between 2001 and 2013. These retrospective analyses aimed to delineate tumor characteristics, surgical history, and survival distribution. METHODS: Data from 254,706 patients with primary gastric cancer were included. The 5-year survival rates were calculated for various subsets of prognostic factors. RESULTS: The number of patients over 70 years old increased from 2001 to 2013. The frequency with which laparoscopic gastrectomy was opted for increased dramatically (from 3.5 to 40.8%) in 13 years. We focused on the patients registered between 2010 and 2013, for whom data collection was based on the 3rd edition of the Japanese classification and guidelines. Five-year overall survival (OS) rate among 92,305 patients with resected tumors was 70.6%. The 5-year OS rates of patients with pathological stage IA, IB, IIA, IIB, IIIA, IIIB, IIIC, and IV disease were 89.6%, 83.2%, 77.6%, 68.1%, 59.3%, 45.6%, 29.9%, and 14.0%, respectively. CONCLUSION: Our detailed analysis highlights the historical changes in outcomes of surgically treated gastric malignancies in Japan, and provides robust dataset for future analysis.
BACKGROUND: The nationwide registry of the Japanese Gastric Cancer Association collected data of surgically resected cases of gastric cancer between 2001 and 2013. These retrospective analyses aimed to delineate tumor characteristics, surgical history, and survival distribution. METHODS: Data from 254,706 patients with primary gastric cancer were included. The 5-year survival rates were calculated for various subsets of prognostic factors. RESULTS: The number of patients over 70 years old increased from 2001 to 2013. The frequency with which laparoscopic gastrectomy was opted for increased dramatically (from 3.5 to 40.8%) in 13 years. We focused on the patients registered between 2010 and 2013, for whom data collection was based on the 3rd edition of the Japanese classification and guidelines. Five-year overall survival (OS) rate among 92,305 patients with resected tumors was 70.6%. The 5-year OS rates of patients with pathological stage IA, IB, IIA, IIB, IIIA, IIIB, IIIC, and IV disease were 89.6%, 83.2%, 77.6%, 68.1%, 59.3%, 45.6%, 29.9%, and 14.0%, respectively. CONCLUSION: Our detailed analysis highlights the historical changes in outcomes of surgically treated gastric malignancies in Japan, and provides robust dataset for future analysis.